Search Results - "Smits, Sander H. J."

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5 by Harris, Andrzej, Wagner, Manuel, Du, Dijun, Raschka, Stefanie, Nentwig, Lea-Marie, Gohlke, Holger, Smits, Sander H. J., Luisi, Ben F., Schmitt, Lutz

“…Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5…”
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Substrate Specificity of the Secreted Nisin Leader Peptidase NisP by Lagedroste, Marcel, Smits, Sander H. J, Schmitt, Lutz

“…Nisin (NisA) is an antimicrobial peptide produced by Lactococcus lactis and belongs to the class of lanthipeptides, more specifically to the class of…”
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The Chlamydia pneumoniae effector SemD exploits its host’s endocytic machinery by structural and functional mimicry by Kocher, Fabienne, Applegate, Violetta, Reiners, Jens, Port, Astrid, Spona, Dominik, Hänsch, Sebastian, Mirzaiebadizi, Amin, Ahmadian, Mohammad Reza, Smits, Sander H. J., Hegemann, Johannes H., Mölleken, Katja

“…To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the…”
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Type 1 secretion necessitates a tight interplay between all domains of the ABC transporter by Anlauf, Manuel T., Bilsing, Florestan L., Reiners, Jens, Spitz, Olivia, Hachani, Eymen, Smits, Sander H. J., Schmitt, Lutz

“…Type I secretion systems (T1SS) facilitate the secretion of substrates in one step across both membranes of Gram-negative bacteria. A prime example is the…”
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Cloning and expression of selected ABC transporters from the Arabidopsis thaliana ABCG family in Pichia pastoris by Gräfe, Katharina, Shanmugarajah, Kalpana, Zobel, Thomas, Weidtkamp-Peters, Stefanie, Kleinschrodt, Diana, Smits, Sander H J, Schmitt, Lutz

“…Phytohormones play a major role in plant growth and development. They are in most cases not synthesized in their target location and hence need to be…”
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Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance by Khosa, Sakshi, Hoeppner, Astrid, Gohlke, Holger, Schmitt, Lutz, Smits, Sander H J

“…Lantibiotics are antimicrobial peptides produced by Gram-positive bacteria. Interestingly, several clinically relevant and human pathogenic strains are…”
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New insights into the resistance mechanism for the BceAB-type transporter SaNsrFP by Gottstein, Julia, Zaschke-Kriesche, Julia, Unsleber, Sandra, Voitsekhovskaia, Irina, Kulik, Andreas, Behrmann, Lara V., Overbeck, Nina, Stühler, Kai, Stegmann, Evi, Smits, Sander H. J.

“…Treatment of bacterial infections is one of the major challenges of our time due to the evolved resistance mechanisms of pathogens against antibiotics. To…”
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EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay by Kroeger, Tobias, Frieg, Benedikt, Zhang, Tao, Hansen, Finn K, Marmann, Andreas, Proksch, Peter, Nagel-Steger, Luitgard, Groth, Georg, Smits, Sander H J, Gohlke, Holger

“…Ethylenediaminetetraacetic acid (EDTA) is widely used in the life sciences as chelating ligand of metal ions. However, formation of supramolecular EDTA…”
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Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects by Gopalswamy, Mohanraj, Kroeger, Tobias, Bickel, David, Frieg, Benedikt, Akter, Shahina, Schott-Verdugo, Stephan, Viegas, Aldino, Pauly, Thomas, Mayer, Manuela, Przibilla, Julia, Reiners, Jens, Nagel-Steger, Luitgard, Smits, Sander H. J., Groth, Georg, Etzkorn, Manuel, Gohlke, Holger

“…Acute myeloid leukemia (AML) is a malignant disease of immature myeloid cells and the most prevalent acute leukemia among adults. The oncogenic homo-tetrameric…”
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Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell by Erenburg, Isabelle N., Hänsch, Sebastian, Chacko, Feby M., Hamacher, Anna, Wintgens, Sebastian, Stuhldreier, Fabian, Poschmann, Gereon, Spitz, Olivia, Stühler, Kai, Wesselborg, Sebastian, Hegemann, Johannes H., Smits, Sander H. J., Weidtkamp-Peters, Stefanie, Schmitt, Lutz

“…Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli . RTX…”
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Biochemistry and Crystal Structure of Ectoine Synthase: A Metal-Containing Member of the Cupin Superfamily by Widderich, Nils, Kobus, Stefanie, Höppner, Astrid, Riclea, Ramona, Seubert, Andreas, Dickschat, Jeroen S, Heider, Johann, Smits, Sander H J, Bremer, Erhard

“…Ectoine is a compatible solute and chemical chaperone widely used by members of the Bacteria and a few Archaea to fend-off the detrimental effects of high…”
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Lantibiotic immunity: inhibition of nisin mediated pore formation by NisI by AlKhatib, Zainab, Lagedroste, Marcel, Fey, Iris, Kleinschrodt, Diana, Abts, André, Smits, Sander H J

“…Nisin, a 3.4 kDa antimicrobial peptide produced by some Lactococcus lactis strains is the most prominent member of the lantibiotic family. Nisin can inhibit…”
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An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate by Perez-Garcia, Pablo, Chow, Jennifer, Costanzi, Elisa, Gurschke, Marno, Dittrich, Jonas, Dierkes, Robert F., Molitor, Rebecka, Applegate, Violetta, Feuerriegel, Golo, Tete, Prince, Danso, Dominik, Thies, Stephan, Schumacher, Julia, Pfleger, Christopher, Jaeger, Karl-Erich, Gohlke, Holger, Smits, Sander H. J., Schmitz, Ruth A., Streit, Wolfgang R.

“…Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 80 bacterial and…”
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Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11 by Nouri, Kazem, Moll, Jens M, Milroy, Lech-Gustav, Hain, Anika, Dvorsky, Radovan, Amin, Ehsan, Lenders, Michael, Nagel-Steger, Luitgard, Howe, Sebastian, Smits, Sander H J, Hengel, Hartmut, Schmitt, Lutz, Münk, Carsten, Brunsveld, Luc, Ahmadian, Mohammad R

“…Nucleophosmin (NPM1, also known as B23, numatrin or NO38) is a pentameric RNA-binding protein with RNA and protein chaperon functions. NPM1 has increasingly…”
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Structure and Function of Hepatobiliary ATP Binding Cassette Transporters by Kroll, Tim, Prescher, Martin, Smits, Sander H. J, Schmitt, Lutz

“…The liver is beyond any doubt the most important metabolic organ of the human body. This function requires an intensive crosstalk within liver cellular…”
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Dimethylglycine provides salt and temperature stress protection to Bacillus subtilis by Bashir, Abdallah, Hoffmann, Tamara, Smits, Sander H J, Bremer, Erhard

“…Glycine betaine is a potent osmotic and thermal stress protectant of many microorganisms. Its synthesis from glycine results in the formation of the…”
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A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri - Structural and Functional Insights by Bollinger, Alexander, Thies, Stephan, Knieps-Grünhagen, Esther, Gertzen, Christoph, Kobus, Stefanie, Höppner, Astrid, Ferrer, Manuel, Gohlke, Holger, Smits, Sander H J, Jaeger, Karl-Erich

“…Biodegradation of synthetic polymers, in particular polyethylene terephthalate (PET), is of great importance, since environmental pollution with PET and other…”
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A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family by Perez-Garcia, Pablo, Kobus, Stefanie, Gertzen, Christoph G. W., Hoeppner, Astrid, Holzscheck, Nicholas, Strunk, Christoph Heinrich, Huber, Harald, Jaeger, Karl-Erich, Gohlke, Holger, Kovacic, Filip, Smits, Sander H. J., Streit, Wolfgang R., Chow, Jennifer

“…The metallo-β-lactamase fold is an ancient protein structure present in numerous enzyme families responsible for diverse biological processes. The crystal…”
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Binding Region of Alanopine Dehydrogenase Predicted by Unbiased Molecular Dynamics Simulations of Ligand Diffusion by Gohlke, Holger, Hergert, Ulrike, Meyer, Tatu, Mulnaes, Daniel, Grieshaber, Manfred K, Smits, Sander H. J, Schmitt, Lutz

“…Opine dehydrogenases catalyze the reductive condensation of pyruvate with l-amino acids. Biochemical characterization of alanopine dehydrogenase from Arenicola…”
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Functional Impact of a Single Mutation within the Transmembrane Domain of the Multidrug ABC Transporter Pdr5 by Kueppers, Petra, Gupta, Rakeshkumar P, Stindt, Jan, Smits, Sander H. J, Schmitt, Lutz

“…The pleiotropic drug resistance network in budding yeast presents a first line of defense against xenobiotics, which is formed by primary and secondary active…”
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