Search Results - "Smits, P H M"

HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53 by Meulendijks, D, Tomasoa, N B, Dewit, L, Smits, P H M, Bakker, R, van Velthuysen, M-L F, Rosenberg, E H, Beijnen, J H, Schellens, J H M, Cats, A

“…Background: Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head and neck squamous cell carcinoma, but their…”
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Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine by Joerger, M., Burgers, J. A., Baas, P., Doodeman, V. D., Smits, P. H. M., Jansen, R. S., Vainchtein, L. D., Rosing, H., Huitema, A. D. R., Beijnen, J. H., Schellens, J. H. M.

“…Background This study quantified the impact of drug pathway-associated genetic variants on the pharmacokinetics (PK) of gemcitabine and cisplatin in patients…”
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Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy by Joerger, M., Huitema, A. D. R., Boot, H., Cats, A., Doodeman, V. D., Smits, P. H. M., Vainchtein, L., Rosing, H., Meijerman, I., Zueger, M., Meulendijks, D., Cerny, T. D., Beijnen, J. H., Schellens, J. H. M.

“…Purpose This work was initiated to extend data on the effect of pharmacogenetics and chemotherapy pharmacokinetics (PK) on clinical outcome in patients with…”
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Novel deoxycytidine kinase gene polymorphisms : a population screening study in Caucasian healthy volunteers by JOERGER, M, BOSCH, T. M, DOODEMAN, V. D, BEIJNEN, J. H, SMITS, P. H. M, SCHELLENS, J. H. M

“…Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and…”
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Effect of HIV viral load, CD4 cell count and antiretroviral therapy on human papillomavirus prevalence in urine samples of HIV-infected men by Jong, E, van Gorp, E C M, Mulder, J W, Tol, A, Smits, P H M

“…HIV-infected patients are at increased risk for persistent human papillomavirus (HPV) infection, the major cause of anogenital cancer. The present study…”
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Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population by Bosch, T M, Doodeman, V D, Smits, P H M, Meijerman, I, Schellens, J H M, Beijnen, J H

“…A possible explanation for the wide interindividual variability in toxicity and efficacy of drug therapy is variation in genes encoding drug-metabolizing…”
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Comparative analysis of human papillomavirus infections in cervical scrapes and biopsy specimens by general SPF10 PCR and HPV genotyping by Quint, W. G. V., Scholte, G., van Doorn, L. J., Kleter, B., Smits, P. H. M., Lindeman, J.

“…Human papillomavirus (HPV) can be detected by DNA amplification from clinical samples. The aim of the present study was to compare the HPV status in both…”
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The role of platelets in venous thrombosis: a patient with Glanzmann's thrombasthenia and a factor V Leiden mutation suffering from deep venous thrombosis by Ten Cate, H., Brandjes, D.P.M., Smits, P. H. M., Van Mourik, J.A.

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Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers by Joerger, M., Bosch, T. M., Doodeman, V. D., Beijnen, J. H., Smits, P. H. M., Schellens, J. H. M.

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Detection of late pp67-mRNA by NASBA in peripheral blood for the diagnosis of human cytomegalovirus disease in AIDS patients by Blank, B.S.N, Meenhorst, P.L, Pauw, W, Mulder, J.W, van Dijk, W.C, Smits, P.H.M, Roeles, F, Middeldorp, J.M, Lange, J.M.A

“…Objective: To evaluate the value of late-pp67-mRNA nucleic acid sequence-based amplification (NASBA) in comparison to DNA-PCR, blood culture and…”
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Management of drug interactions with direct‐acting antivirals in Dutch HIV/hepatitis C virus‐coinfected patients: adequate but not perfect by Rijnders, B, Valk, M, Burger, DM, Meer, J. T. M., Nellen, F. J. B., Pajkrt, D., Goorhuis, A., Hovius, J. W., Eden, J., Back, N. K. T., Berkhout, B., Cornelissen, M. T. E., Wintermans, B., Ziekenhuis, Catharina, Beek, E., Jansz, A. R., Tjhie, J., Brouwer, A. E., Erve, R., Keelan‐Pfaf, S., Buiting, A. G. M., Kinderziekenhuis, Emma, Plas, A., Gorp, E. C. M., Beek, J. E. A., Vriesde, M., Zonneveld, L. M., Berg‐Cameron, H. J., Pas, S. D., Elsenburg, L. J. M., Kwa, I. S., Groeneveld, P. H. P., Berg, J. F., Bliek, G. L., Bor, P. C. J., Bloembergen, P., Boer, M. G. J., Jolink, H., Claas, E. C. J., Hollander, J. G., Kastelijns, M., Smit, J. V., Struik‐Kalkman, D., Tearno, C., Loo, I. H. M., Hartingsveld, A. Y., Mutsaers, J. A. E. M., Veen, S. Q., Slotervaart, MC, Vlasblom, D. J., Smits, P. H. M., Houte, D. P. F., Kampschreur, L. M., Kootstra, G. J., Kortmann, W., Cohen Stuart, J. W. T., Diederen, B. M. W., Renckens, R., Blok, W. L., Brouwer, C. J., Geerders, G. F., Kleene, M. J., Meché, I. B., Spelbrink, M., Crevel, R., Ven, A. J. A. M., Rahamat‐Langendoen, J., Swanink, C. M. A., Lelyveld, S. F. L., Soetekouw, R., Prijt, L. M. M., Swaluw, J., Verhagen, D. W. M., Wijk, M., Bakker, M., Kleinnijenhuis, J., Kloeze, E., Vermont, C. L., Boonstra, A., Leer‐Buter, C. C., Oosterheert, J. J., Agtmael, M. A., Bomers, M., Heitmuller, M., Laan, L. M., Ang, C. W., Houdt, R., Pettersson, A. M., Wolfs, T. F. W., Nauta, N., Bezemer, D. O., Sighem, A. I., Boender, T. S., Zaheri, S., Bakker, Y., Koops, J., Kruijne, E., Munjishvili, L., Ruijs, Y., Rutkens, T.

“…Objectives Direct‐acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug–drug interactions (DDIs) with combination…”
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Drug pathway–associated gene polymorphisms in patients with advanced non-small cell lung cancer receiving first-line platinum-gemcitabine combination chemotherapy: A prospective multicenter observational study by Joerger, M., Burgers, S. A., Baas, P., Smit, E. F., Haitjema, T. J., Bard, M. P. L., Doodeman, V. D., Smits, P. H. M., Vincent, A., Huitema, A., Beijnen, J. H., Schellens, J. H. M.

“…Abstract only…”
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Safety, pharmacokinetics (PK), and cost-effectiveness of upfront genotyping of DPYD in fluoropyrimidine therapy by Deenen, M. J., Cats, A., Sechterberger, M. K., Severens, J. L., Smits, P. H. M., Bakker, R., Mandigers, C. M., Soesan, M., Beijnen, J. H., Schellens, J. H. M.

“…Abstract only…”
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Regulation of human papillomavirus type 16 (HPV-16) transcription by loci on the short arm of chromosome 11 is mediated by the TATAAAA motif of the HPV-16 promoter by Smits, Paul H. M, Smits, Henk L, Minnaar, Rene P, ter Schegget, Jan

“…Department of Medical Microbiology, Section Fundamental Virology, Academic Medical Centre, University of Amsterdam, Room L1-158, Meibergdreef 15, 1105 AZ…”
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Recurrent increase of liver enzymes in a human immunodeficiency virus infected male with recent acute hepatitis B infection by van Es, J, Wagenaar, J F P, Smits, P H M, Depla, A C T M, van Gorp, E C M, Mulder, J W

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The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A by DUYNDAM, M. C. A, VAN DAM, H, SMITS, P. H. M, VERLAAN, M, VAN DER EB, A. J, ZANTEMA, A

“…The adenovirus E1A proteins activate the c-jun promoter through two Jun/ATF-binding sites, jun1 and jun2. P300, a transcriptional coactivator of several AP1…”
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Automated, simultaneous detection of the factor V Leiden and prothrombin (G20210A) variants using multiplex PCR and a line probe assay by Leyte, A, Smits, P H, van Straalen, J P, van Doorn, L J, Quint, W G

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The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11 by Smits, P.H., Smits, H.L., Minnaar, R.P., Hemmings, B.A., Mayer‐Jaekel, R.E., Schuurman, R., Noordaa, J., Schegget, J.

“…Previous results indicated that SV40 small t is essential for SV40‐induced transformation of diploid cells but dispensable for the transformation of cells with…”
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The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene by Smits, P H, De Haan, M, Maat, C, Grivell, L A

“…We report here the sequence of a 33,117 bp DNA fragment located approximately 30 kb from the centromere on the right arm of Saccharomyces cerevisiae chromosome…”
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The short arm of chromosome 11 likely is involved in the regulation of the human papillomavirus type 16 early enhancer-promoter and in the suppression of the transforming activity of the viral DNA by Smits, P H, Smits, H L, Jebbink, M F, ter Schegget, J

“…Loci on the short arm of chromosome 11 between 11p11 and 11p15 likely are involved directly or indirectly in the regulation of the HPV-16 enhancer-promoter…”
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