Search Results - "Smits, K. M."

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis by Simons, C.C.J.M., Hughes, L.A.E., Smits, K.M., Khalid-de Bakker, C.A., de Bruïne, A.P., Carvalho, B., Meijer, G.A., Schouten, L.J., van den Brandt, P.A., Weijenberg, M.P., van Engeland, M.

“…We studied the overlap between the major (epi)genomic events microsatellite instability (MSI), the CpG island methylator phenotype (CIMP) and chromosomal…”
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Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review by SMITS, K. M, SMITS, L. J. M, SCHOUTEN, Jsag, STELMA, F. F, NELEMANS, P, PRINS, M. H

“…Large differences in clinical response to selective serotonin reuptake inhibitors (SSRIs) are observed in depressive patients with different genotypes…”
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Development of a prognostic risk model for clear cell renal cell carcinoma by systematic evaluation of DNA methylation markers by Joosten, S C, Odeh, S N O, Koch, A, Buekers, N, Aarts, M J B, Baldewijns, M M L L, Van Neste, L, van Kuijk, S, Schouten, L J, van den Brandt, P A, Tjan-Heijnen, V C, van Engeland, M, Smits, K M

“…Current risk models for renal cell carcinoma (RCC) based on clinicopathological factors are sub-optimal in accurately identifying high-risk patients. Here, we…”
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Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study by VAN DEN BRANDT, P. A, SMITS, K. M, GOLDBOHM, R. A, WEIJENBERG, M. P

“…Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and…”
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Gas Component Transport Across the Soil‐Atmosphere Interface for Gases of Different Density: Experiments and Modeling by Bahlmann, L. M., Smits, K. M., Heck, K., Coltman, E., Helmig, R., Neuweiler, I.

“…We investigate the influence of near‐surface wind conditions on subsurface gas transport and on soil‐atmosphere gas exchange for gases of different density…”
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Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine by OKADA, H, GIEZEMAN-SMITS, K. M, TAHARA, H, ATTANUCCI, J, FELLOWS, W. K, LOTZE, M. T, CHAMBERS, W. H, BOZIK, M. E

“…To explore the potential for molecular immunotherapies in the treatment of malignant gliomas, we evaluated the efficacy of subcutaneous tumor cell vaccines in…”
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Flt-3 ligand (FL) drives differentiation of rat bone marrow-derived dendritic cells expressing OX62 and/or CD161 (NKR-P1) by Cynthia S. Brissette-Storkus, J. C. Kettel, T. F. Whitham, K. M. Giezeman-Smits, L. A. Villa, D. M. Potter, William H. Chambers

“…Bone marrow‐derived dendritic cells (DC) of the rat have not been as well characterized as those from the mouse. Here, large quantities of bone marrow‐derived…”
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Bone marrow‐derived dendritic cells pulsed with a tumor‐specific peptide elicit effective anti‐tumor immunity against intracranial neoplasms by Okada, Hideho, Tahara, Hideaki, Shurin, Michael R., Attanucci, Jason, Giezeman‐Smits, Katinka M., Fellows, Wendy K., Lotze, Michael T., Chambers, William H., Bozik, Michael E.

“…Although the central nervous system (CNS) is often regarded as an immunologically privileged site, it is well established that specific CNS immunoreactivity…”
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Cytokine gene therapy of gliomas : Induction of reactive CD4+T cells by interleukin-4-transfected 9L gliosarcoma is essential for protective immunity by GIEZEMAN-SMITS, K. M, OKADA, H, BRISSETTE-STORKUS, C. S, VILLA, L. A, ATTANUCCI, J, LOTZE, M. T, POLLACK, I. F, BOZIK, M. E, CHAMBERS, W. H

“…Tumor cells genetically modified to secrete cytokines stimulate potent immune responses against peripheral and central nervous system tumors; however, variable…”
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Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study by Smits, K. M., Gaspari, L., Weijenberg, M. P., Dolzan, V., Golka, K., Roemer, H. C., Nedelcheva Kristensen, V., Lechner, M. C., Mehling, G. I., Seidegard, J., Strange, R. C., Taioli, E.

“…Cigarette smoking has inconsistently been associated with an increased risk of colorectal cancer. One of the enzymes responsible for the detoxification of the…”
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K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study by Brink, Mirian, de Goeij, Anton F.P.M., Weijenberg, Matty P., Roemen, Guido M.J.M., Lentjes, Marjolein H.F.M., Pachen, Marco M.M., Smits, Kim M., de Bruïne, Adriaan P., Goldbohm, R. Alexandra, van den Brandt, Piet A.

“…Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being mutated in 30–60% of the adenocarcinomas. In this study, 737 incident…”
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Rat interleukin-2-activated natural killer (A-NK) cell-mediated lysis is determined by the presence of CD18 on A-NK cells and the absence of major histocompatibility complex class I on target cells by Smits, K M, Kuppen, P J, Eggermont, A M, Tamatani, T, Miyasaka, M, Fleuren, G J

“…The precise mechanism by which target cells are recognized and subsequently lysed by interleukin-2-activated natural killer (A-NK) cells is poorly understood…”
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Preincubation of tumor cells with the anti-(MHC) class I antibody OX18 enhances tumor cell lysis by interleukin-2-activated NK cells by Smits, K M, Kuppen, P J, Eggermont, A M, Fleuren, G J

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Major histocompatibility complex class I expression and sensitivity to interleukin-2 activated NK cell-mediated lysis of adenovirus-transformed baby rat kidney cells by Smits, K M, Kuppen, P J, Lazeroms, S P, Eggermont, A M, Fleuren, G J

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Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells by Giezeman‐Smits, Katinka M., Jonges, Liesbeth E., Chambers, William H., Brisette‐Storkus, Cynthia S., Vlierberghe, Ronald L. P., Eendenburg, Jaap D. H., Eggermont, Alexander M. M., Fleuren, Gert Jan, Kuppen, Peter J. K.

“…Interleukin‐2 (IL‐2)‐activated natural killer (NK) cells are known to mediate specific functions such as cytolytic activity and tumor infiltration more…”
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Immunization with an antigen identified by cytokine tumor vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma in vivo by OKADA, Hideho, ATTANUCCI, Jason, CHAMBERS, William H, GIEZEMAN-SMITS, Katinka M, BRISSETTE-STORKUS, Cynthia, FELLOWS, Wendy K, GAMBOTTO, Andrea, POLLACK, Ian F, POGUE-GEILE, Kay, LOTZE, Michael T, BOZIK, Michael E

“…We have reported previously that s.c. immunization of rats with IL-4 transduced 9L gliosarcoma cells (9L-IL-4) induced a potent antitumor immunity against…”
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The development and purification of a bispecific antibody for lymphokine-activated killer cell targeting against the rat colon carcinoma CC531 by KUPPEN, P. J. K, EGGERMONT, A. M. M, SMITS, K. M, VAN EENDENBURG, J. D. H, LAZEROMS, S. P. G, VAN DE VELDE, C. J. H, FLEUREN, G. J

“…In vivo targeting of lymphokine-activated killer (LAK) cells to tumour deposits by bispecific monoclonal antibodies (bimAb) may be a way to improve adoptive…”
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Role of NK cells in adoptive immunotherapy of metastatic colorectal cancer in a syngeneic rat model by Kuppen, Peter J. K., Gorter, Arko, Hagenaars, Martin, Jonges, Liesbeth E., Giezeman-Smits, Katinka M., Nagelkerke, J. Fred, Fleuren, Gertjan, Van De Velde, Cornelis J. H.

“…This article reviews our immunotherapy research with natural killer (NK) cells in a syngeneic rat colorectal cancer liver and lung metastasis model. Using…”
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The Regulatory Role of CD45 on Rat NK Cells in Target Cell Lysis by Giezeman-Smits, Katinka M, Gorter, Arko, van Vlierberghe, Ronald L. P, v. Eendenburg, Jaap D. H, Eggermont, Alexander M. M, Fleuren, Gert Jan, Kuppen, Peter J. K

“…To investigate the role of CD45 in rat NK cell function, we developed new mAbs directed against rat CD45. mAb ANK12 binds to a high molecular isoform of CD45…”
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NK Cells Modulate MHC Class I Expression on Tumor Cells and their Susceptibility to Lysis by Jonges, Liesbeth E., Giezeman-Smits, Katinka M., Van Vlierberghe, Ronald LP, Ensink, NGeeske, Hagenaars, Martin, Joly, étienne, Eggermont, Alexander MM, Van De Velde, Cornelis JH, Fleuren, Gert Jan, Kuppen, Peter JK

“…Cytotoxicity and production of cytokines are two important functions of NK cellsThese two different NK functions were studied in a syngeneic rat model in…”
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