Search Results - "Smithrud, David B."

A Versatile Axle for the Construction of Disassemblage Rotaxanes by Powers, Lucas A, Smithrud, David B

“…Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and…”
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Determining the Intracellular Transport Mechanism of a Cleft−[2]Rotaxane by Bao, Xiaofeng, Isaacsohn, Idit, Drew, Angela F, Smithrud, David B

“…Rotaxanes are a class of interlocked compounds that have been extensively investigated for their potential utility as switches or sensors. We recently…”
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Host−[2]Rotaxanes as Cellular Transport Agents by Dvornikovs, Vadims, House, Brian E, Kaetzel, Marcia, Dedman, John R, Smithrud, David B

“…Host−[2]rotaxanes, containing a diarginine-derivatized dibenzo-24-crown-8 (DB24C8) ether as the ring and a cyclophane pocket or an aromatic cleft as one…”
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Facile Synthesis of Rotaxanes through Condensation Reactions of DCC-[2]Rotaxanes by Zehnder, Donald W, Smithrud, David B

“…In this Letter, we present an easy method for the synthesis of rotaxanes using a novel DCC-[2]rotaxane. The DCC-[2]rotaxane is composed of dibenzo-24-crown-8…”
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Host−[2]Rotaxane:  Advantage of Converging Functional Groups for Guest Recognition by Smukste, Inese, House, Brian E, Smithrud, David B

“…A host−[2]rotaxane was constructed by converting a diaminophenylcalix[4]arene into a [2]rotaxane using the DCC-rotaxane method (Zehnder, D.; Smithrud, D. B…”
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Pencil–Paper Learning Should Be Combined with Online Homework Software by Smithrud, David B, Pinhas, Allan R

“…For the past eight years, we have used online homework software as a pedagogical tool for undergraduate students (almost all are second-year students) learning…”
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Pt-rotaxanes as cytotoxic agents by Wang, Xiaoyang, Smithrud, David B.

“…Cytotoxic agents that specifically target cancer cells are in high demand. Modifying drugs with targeting groups however, can produce deleterious effects on…”
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Ca2+ Selective Host Rotaxane Is Highly Toxic Against Prostate Cancer Cells by Smithrud, David B., Powers, Lucas, Lunn, Jennifer, Abernathy, Scott, Peschka, Michael, Ho, Shuk-mei, Tarapore, Pheruza

“…New therapies are needed to eradicate androgen resistant, prostate cancer. Prostate cancer usually metastasizes to bone where the concentration of calcium is…”
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Enthalpically driven cyclophane-arene inclusion complexation: solvent-dependent calorimetric studies by Smithrud, David B, Wyman, Tara B, Diederich, Francois

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Strength of molecular complexation of apolar solutes in water and in organic solvents is predictable by linear free energy relationships: a general model for solvation effects on apolar binding by Smithrud, David B, Diederich, Francois

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Synthesis and Investigation of Host-[2]Rotaxanes That Bind Metal Cations by Wang, Xiaoyang, Zhu, Jing, Smithrud, David B

“…Materials that bind metal cations are highly sought after for new devices. In this report, we show that rotaxanes can transfer metal cations with picrate,…”
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Ca 2+ Selective Host Rotaxane Is Highly Toxic Against Prostate Cancer Cells by Smithrud, David B, Powers, Lucas, Lunn, Jennifer, Abernathy, Scott, Peschka, Michael, Ho, Shuk-Mei, Tarapore, Pheruza

“…New therapies are needed to eradicate androgen resistant, prostate cancer. Prostate cancer usually metastasizes to bone where the concentration of calcium is…”
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Crown Ether Host-Rotaxanes as Cytotoxic Agents by Smithrud, David B, Wang, Xiaoyang, Tarapore, Pheruza, Ho, Shuk-mei

“…Highly toxic bacterial ionophores are commonly used in veterinary medicine, but their therapeutic index is too narrow for human usage. With the goal of…”
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Investigation of the Intracellular Delivery of Fluoresceinated Peptides by a Host-[2]Rotaxane by Wang, Xiaoyang, Bao, Xiaofeng, McFarland-Mancini, Molly, Isaacsohn, Idit, Drew, Angela F, Smithrud, David B

“…The development of methods to transport peptides into cells via a passive mechanism would greatly aid in the development of therapeutic agents. We recently…”
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Host-rotaxanes with oligomeric axles are intracellular transport agents by Zhu, Jing, McFarland-Mancini, Molly, Drew, Angela F., Smithrud, David B.

“…Polymeric macromolecules are promising drug delivery devices with endocytotic properties that need to be resolved. Host-rotaxanes (HRs) also deliver materials…”
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Determining the Binding and Intracellular Transporting Abilities of a Host-[3]Rotaxane by Bao, Xiaofeng, Isaacsohn, Idit, Drew, Angela F, Smithrud, David B

“…The cellular permeability of compounds can be enhanced in the presence of a host-[2]rotaxane (HR). The effective concentration of an HR is limited by the…”
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Host-rotaxanes model proteins that promote ligand association through a favorable change in configurational entropy by Zhu, Jing, Smithrud, David B

“…Proteins can reduce the entropic penalty for ligand association through a favorable change in configurational entropy. To investigate this process, the Delta…”
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Structure−Function Relationship of Amino Acid−[2]Rotaxanes by Smukste, Inese, Smithrud, David B

“…Synthetic methodology was developed to construct amino acid−[2]rotaxanes that have phenylalanine and 3,5-di-tert-butylbenzene as blocking groups and…”
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Cyclic Peptide Formation Catalyzed by an Antibody Ligase by Smithrud, David B., Benkovic, Patricia A., Benkovic, Stephen J., Roberts, Victoria, Liu, Josephine, Neagu, Irina, Iwama, Seiji, Phillips, Barton W., Smith, Amos B., Hirschmann, Ralph

“…Cyclic hexapeptides represent a class of compounds with important, diverse biological activities. We report herein that the antibody 16G3 catalyzes the…”
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Carboxylates Stacked over Aromatic Rings Promote Salt Bridge Formation in Water by Thompson, Samuel E, Smithrud, David B

“…Several salt bridges observed in protein X-ray crystallographic structures showed a consistent pattern of a carboxylate, situated near the face of an aromatic…”
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