Search Results - "Smith, W.J."

Alternative pre-mRNA splicing: the logic of combinatorial control by Smith, Christopher W.J, Valcárcel, Juan

“…Alternative splicing of mRNA precursors is a versatile mechanism of gene expression regulation that accounts for a considerable proportion of proteomic…”
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Defining the roles and interactions of PTB by Kafasla, Panagiota, Mickleburgh, Ian, Llorian, Miriam, Coelho, Miguel, Gooding, Clare, Cherny, Dmitry, Joshi, Amar, Kotik-Kogan, Olga, Curry, Stephen, Eperon, Ian C, Jackson, Richard J, Smith, Christopher W J

“…PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains. PTB is…”
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Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay by Wollerton, Matthew C, Gooding, Clare, Wagner, Eric J, Garcia-Blanco, Mariano A, Smith, Christopher W.J

“…Polypyrimdine tract binding protein (PTB) is a regulator of alternative splicing, mRNA 3′ end formation, mRNA stability and localization, and IRES-mediated…”
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Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing by Attig, Jan, Agostini, Federico, Gooding, Clare, Chakrabarti, Anob M., Singh, Aarti, Haberman, Nejc, Zagalak, Julian A., Emmett, Warren, Smith, Christopher W.J., Luscombe, Nicholas M., Ule, Jernej

“…Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs)…”
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Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense? by McGlincy, Nicholas J., Smith, Christopher W.J.

“…Alternative splicing (AS) strongly affects gene expression by generating protein isoform diversity. However, up to one-third of human AS events create a…”
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Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1 by Spellman, Rachel, Llorian, Miriam, Smith, Christopher W.J.

“…Among the targets of the repressive splicing regulator, polypyrimidine tract binding protein (PTB) is its own pre-mRNA, where PTB-induced exon 11 skipping…”
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Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing by Joshi, Amar, Coelho, Miguel B., Kotik-Kogan, Olga, Simpson, Peter J., Matthews, Stephen J., Smith, Christopher W.J., Curry, Stephen

“…The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of α-tropomyosin is enhanced by…”
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The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators by Llorian, Miriam, Gooding, Clare, Bellora, Nicolas, Hallegger, Martina, Buckroyd, Adrian, Wang, Xiao, Rajgor, Dipen, Kayikci, Melis, Feltham, Jack, Ule, Jernej, Eyras, Eduardo, Smith, Christopher W J

“…Alternative splicing (AS) is a key component of gene expression programs that drive cellular differentiation. Smooth muscle cells (SMCs) are important in the…”
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Specific cleavage of hyper-edited dsRNAs by Scadden, A.D.J., Smith, Christopher W.J.

“…Extended double‐stranded DNA (dsRNA) duplexes can be hyper‐edited by adenosine deaminases that act on RNA (ADARs). Long uninterrupted dsRNA is relatively…”
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Boekbesprekings: Book reviews by W.J. Smith

“…Coming of age: Exploring the identity and spirituality of younger men Deliver us from evil: Interpreting the redemption from the power of Satan in New…”
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MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3 by Gooding, Clare, Edge, Christopher, Lorenz, Mike, Coelho, Miguel B, Winters, Mikael, Kaminski, Clemens F, Cherny, Dmitry, Eperon, Ian C, Smith, Christopher W J

“…Exon 3 of the rat α-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2. Two key types of…”
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The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes by Yip, Bon Ham, Steeples, Violetta, Repapi, Emmanouela, Armstrong, Richard N, Llorian, Miriam, Roy, Swagata, Shaw, Jacqueline, Dolatshad, Hamid, Taylor, Stephen, Verma, Amit, Bartenstein, Matthias, Vyas, Paresh, Cross, Nicholas Cp, Malcovati, Luca, Cazzola, Mario, Hellström-Lindberg, Eva, Ogawa, Seishi, Smith, Christopher Wj, Pellagatti, Andrea, Boultwood, Jacqueline

“…Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (MDS), a myeloid malignancy, and other cancers. Patients…”
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Metal sorbents for high temperature mercury capture from fuel gas by Poulston, Stephen, Granite, Evan J., Pennline, Henry W., Myers, Christina R., Stanko, Dennis P., Hamilton, Hugh, Rowsell, Liz, Smith, Andrew W.J., Ilkenhans, Thomas, Chu, Wilson

“…We have determined the Hg removal capacities of Pt and Pd supported on alumina at a range of different metal loadings from 2 to 9 wt% using Hg vapour in a…”
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Genome-wide association between branch point properties and alternative splicing by Corvelo, André, Hallegger, Martina, Smith, Christopher W J, Eyras, Eduardo

“…The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing. In mammals, the degeneracy of the motif combined with the lack of…”
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Alternative Splicing— When Two’s a Crowd by Smith, Christopher W.J.

“…Various mechanisms have been proposed to explain mutually exclusive splicing of pairs of exons. A paper in this issue of Cell ( Graveley, 2005) provides a…”
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A Splicing Repressor Domain in Polypyrimidine Tract-binding Protein by Robinson, Fiona, Smith, Christopher W.J.

“…Polypyrimidine tract-binding protein (PTB) is an hnRNP with four RRM type domains. It plays roles as a repressive alternative splicing regulator of multilple…”
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A nonsense exon in the Tpm1 gene is silenced by hnRNP H and F by Coles, Joel L, Hallegger, Martina, Smith, Christopher W J

“…As well as generating protein isoform diversity, in some cases alternative splicing generates RNAs that harbor premature termination codons and that are…”
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Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins by Coelho, Miguel B, Ascher, David B, Gooding, Clare, Lang, Emma, Maude, Hannah, Turner, David, Llorian, Miriam, Pires, Douglas E V, Attig, Jan, Smith, Christopher W J

“…Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA…”
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Epidemiology of porcine non-specific colitis on Scottish farms by Chase-Topping, M.E., Gunn, G., Strachan, W.D., Edwards, S.A., Smith, W.J., Hillman, K., Stefopoulou, S.N., Thomson, J.R.

“…The objective of this study was to investigate epidemiological risk factors for porcine non-specific colitis (NSC). Forty-seven Scottish pig farms, with and…”
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Are Computing Students Different? An Analysis of Coping Strategies and Emotional Intelligence by Belanger, F., Lewis, T., Kasper, G.M., Smith, W.J., Harrington, K.V.

“…As the number of students enrolling in computing majors [computer science (CS), information systems (IS), information technology (IT)] has declined, retaining…”
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