Search Results - "Smith, U."
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Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids
Published in Journal of internal medicine (01-11-2016)“…Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces insulin resistance in peripheral insulin target tissues. Several…”
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12th Key Symposium Introduction: insulin resistance in common diseases
Published in Journal of internal medicine (01-11-2016)“…Content List – Read more articles from the symposium: 12th Key Symposium ‐ Insulin Resistance in Common Diseases…”
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Similar response of labile and resistant soil organic matter pools to changes in temperature. [Erratum: 2005 Aug. 11, v. 436, no. 7052, p. 881.]
Published in Nature (06-01-2005)“…Our understanding of the relationship between the decomposition of soil organic matter (SOM) and soil temperature affects our predictions of the impact of…”
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Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer
Published in Diabetologia (01-06-2007)“…The relative effect of visceral and subcutaneous obesity on the risk of chronic metabolic disease has been a matter of long-term dispute. While ample data…”
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Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?
Published in Journal of internal medicine (01-05-2015)“…Objectives The aim of this study was to characterize diabetes risk in relation to amount and distribution of body fat (environmental factors) and genetic risk…”
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Does diabetes therapy influence the risk of cancer
Published in Diabetologia (01-09-2009)Get full text
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Pioglitazone: mechanism of action
Published in International journal of clinical practice. Supplement (01-09-2001)“…Thiazolidinediones, such as pioglitazone, are synthetic ligands for peroxisome proliferator-activated receptors (PPARs). They alter the transcription of genes…”
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TCF7L2 and type 2 diabetes--we WNT to know
Published in Diabetologia (2007)Get full text
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Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance¾is insulin resistance initiated in the adipose tissue
Published in International Journal of Obesity (01-07-2002)“…This review postulates and presents recent evidence that insulin resistance is initiated in the adipose tissue and also suggests that the adipose tissue may…”
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Recent advances in the molecular pathology, cell biology and genetics of ciliopathies
Published in Journal of medical genetics (01-05-2008)“…Primary cilia have a broad tissue distribution and are present on most cell types in the human body. Until recently, they were considered to be redundant…”
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AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)
Published in Diabetologia (01-11-2010)“…Aim/hypothesis The aim of the study was to examine the possible role of AMP-activated protein kinase (AMPK) in the regulation of the inflammatory response…”
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Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro
Published in Diabetologia (01-10-2012)“…Aims/hypothesis Type 2 diabetes and obesity are associated with increased risk of site-specific cancers. We have investigated whether metabolic alterations at…”
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Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in man
Published in Metabolism, clinical and experimental (01-01-2020)“…Mannose is a glucose-associated serum metabolite mainly released by the liver. Recent studies have shown several unexpected pleiotropic effects of mannose…”
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Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
Published in Diabetologia (01-07-2008)“…Aims/hypothesis IL-6 is released by the adipose tissue and increased circulating levels in obesity are associated with hyperinsulinaemia and insulin…”
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15
Water for small‐scale biogas digesters in sub‐Saharan Africa
Published in Global change biology. Bioenergy (01-02-2017)“…Biogas could provide a more sustainable energy source than wood fuels for rural households in sub‐Saharan African. However, functioning of biogas digesters can…”
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Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis
Published in Diabetologia (01-03-2010)“…Aims/hypothesis Dickkopf-1 (DKK1) is a secreted inhibitor of canonical wingless-type MMTV integration site family (WNT) signalling; the key pathway for cell…”
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Intraocular Pressure and Medication Changes Associated with Xen Gel Stent: A Systematic Review of the Literature
Published in Clinical ophthalmology (Auckland, N.Z.) (01-01-2023)“…The Xen gel stent (Allergan Inc, an AbbVie company; Dublin, Ireland) was conceived as an option for patients requiring modest IOP reduction but for whom…”
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Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study
Published in Diabetologia (01-04-2012)“…Aims/hypothesis Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal…”
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The many facets of the HbA1c test
Published in Journal of internal medicine (01-03-2012)Get full text
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Cancer and diabetes: are we ready for prime time
Published in Diabetologia (01-08-2010)“…Without Abstract…”
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