Search Results - "Smith, Stephen E"

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6 by Smith, Stephen E. P, Li, Jennifer, Garbett, Krassimira, Mirnics, Karoly, Patterson, Paul H

“…Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype and environmental risk factors. The offspring of women…”
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Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring by Bauman, Melissa D, Iosif, Ana-Maria, Smith, Stephen E.P, Bregere, Catherine, Amaral, David G, Patterson, Paul H

“…Background Maternal infection during pregnancy is associated with an increased risk of schizophrenia and autism in the offspring. Supporting this correlation,…”
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SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome by Stamenkovic, Vera, Lautz, Jonathan D., Harsh, Felicia M., Smith, Stephen E. P.

“…Glutamatergic synapses encode information from extracellular inputs using dynamic protein interaction networks (PINs) that undergo widespread reorganization…”
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Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy by Negraes, Priscilla D., Trujillo, Cleber A., Yu, Nam-Kyung, Wu, Wei, Yao, Hang, Liang, Nicholas, Lautz, Jonathan D., Kwok, Ellius, McClatchy, Daniel, Diedrich, Jolene, de Bartolome, Salvador Martinez, Truong, Justin, Szeto, Ryan, Tran, Timothy, Herai, Roberto H., Smith, Stephen E. P., Haddad, Gabriel G., Yates, John R., Muotri, Alysson R.

“…Early-onset epileptic encephalopathies are severe disorders often associated with specific genetic mutations. In this context, the CDKL5 deficiency disorder…”
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Activity dependent dissociation of the Homer1 interactome by Stillman, Mason, Lautz, Jonathan D., Johnson, Richard S., MacCoss, Michael J., Smith, Stephen E. P.

“…Neurons encode information by rapidly modifying synaptic protein complexes, which changes the strength of specific synaptic connections. Homer1 is abundantly…”
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Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease by Caron, Nicholas S, Banos, Raul, Yanick, Christopher, Aly, Amirah E, Byrne, Lauren M, Smith, Ethan D, Xie, Yuanyun, Smith, Stephen E P, Potluri, Nalini, Findlay Black, Hailey, Casal, Lorenzo, Ko, Seunghyun, Cheung, Daphne, Kim, Hyeongju, Seong, Ihn Sik, Wild, Edward J, Song, Ji-Joon, Hayden, Michael R, Southwell, Amber L

“…Huntington disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide repeat expansion in the huntingtin ( ) gene. Therapeutics that lower HTT…”
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Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy by Wright, Moriah, Smith, Stephen E P, Anderson, Matthew P, Zhou, Yu-Dong, Lee, Sanghoon, Jin, Zhe

“…LGI1, a gene linked to epilepsy in humans, promotes disease by impairing the maturation of glutamatergic circuits in the mouse brain. A subset of central…”
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Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models by Brown, Emily A, Lautz, Jonathan D, Davis, Tessa R, Gniffke, Edward P, VanSchoiack, Alison A W, Neier, Steven C, Tashbook, Noah, Nicolini, Chiara, Fahnestock, Margaret, Schrum, Adam G, Smith, Stephen E P

“…Autism spectrum disorders (ASDs) are a heterogeneous group of behaviorally defined disorders and are associated with hundreds of rare genetic mutations and…”
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Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring by Ito, Hiroshi T, Smith, Stephen E.P, Hsiao, Elaine, Patterson, Paul H

“…Abstract The observation that maternal infection increases the risk for schizophrenia in the offspring suggests that the maternal immune system plays a key…”
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A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2 by Tsegay, Kaleb B., Adeyemi, Christiana M., Gniffke, Edward P., Sather, D. Noah, Walker, John K., Smith, Stephen E. P.

“…Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments…”
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Maternal Immune Activation Increases Neonatal Mouse Cortex Thickness and Cell Density by Smith, Stephen E. P., Elliott, Robin M., Anderson, Matthew P.

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Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels by Smith, Stephen E. P., Xu, Lin, Kasten, Michael R., Anderson, Matthew P.

“…J. Neurochem. (2012) 120, 611–621. Activity‐dependent redistribution of ion channels mediates neuronal circuit plasticity and homeostasis, and could provide…”
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Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA -Driven Intractable Epilepsy by Roy, Achira, Han, Victor Z, Bard, Angela M, Wehle, Devin T, Smith, Stephen E P, Ramirez, Jan-Marino, Kalume, Franck, Millen, Kathleen J

“…Patients harboring mutations in the PI3K-AKT-MTOR pathway-encoding genes often develop a spectrum of neurodevelopmental disorders including epilepsy. A…”
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Resolving the Synaptic versus Developmental Dichotomy of Autism Risk Genes by Heavner, Whitney E., Smith, Stephen E.P.

“…Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as either synaptic or developmental. But what if this is a false…”
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Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment by Trujillo, Cleber A, Rice, Edward S, Schaefer, Nathan K, Chaim, Isaac A, Wheeler, Emily C, Madrigal, Assael A, Buchanan, Justin, Preissl, Sebastian, Wang, Allen, Negraes, Priscilla D, Szeto, Ryan A, Herai, Roberto H, Huseynov, Alik, Ferraz, Mariana S A, Borges, Fernando S, Kihara, Alexandre H, Byrne, Ashley, Marin, Maximillian, Vollmers, Christopher, Brooks, Angela N, Lautz, Jonathan D, Semendeferi, Katerina, Shapiro, Beth, Yeo, Gene W, Smith, Stephen E P, Green, Richard E, Muotri, Alysson R

“…The evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 ( ) plays a key role in neural development and function. also includes a…”
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Maternal IL-6 can cause T-cell-mediated juvenile alopecia by non-scarring follicular dystrophy in mice by Smith, Stephen E. P., Maus, Rachel L. G., Davis, Tessa R., Sundberg, John P., Gil, Diana, Schrum, Adam G.

“…Aiming to decipher immunological mechanisms of the autoimmune disorder alopecia areata (AA), we hypothesized that interleukin‐6 (IL‐6) might be associated with…”
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Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice by Smith, Stephen E P, Zhou, Yu-Dong, Zhang, Guangping, Jin, Zhe, Stoppel, David C, Anderson, Matthew P

“…People with autism spectrum disorder are characterized by impaired social interaction, reduced communication, and increased repetitive behaviors. The disorder…”
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IP-FCM measures physiologic protein-protein interactions modulated by signal transduction and small-molecule drug inhibition by Smith, Stephen E P, Bida, Anya T, Davis, Tessa R, Sicotte, Hugues, Patterson, Steven E, Gil, Diana, Schrum, Adam G

“…Protein-protein interactions (PPI) mediate the formation of intermolecular networks that control biological signaling. For this reason, PPIs are of outstanding…”
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Maternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring by Machado, Christopher J, Whitaker, Alexander M, Smith, Stephen E.P, Patterson, Paul H, Bauman, Melissa D

“…Abstract Background Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders. Rodent models have played a…”
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Signalling protein complexes isolated from primary human skin-resident T cells can be analysed by Multiplex IP-FCM by Smith, Stephen E. P., Neier, Steven C., Davis, Tessa R., Pittelkow, Mark R., Gil, Diana, Schrum, Adam G.

“…Studying signal transduction in skin‐resident T cells (sr‐T cells) can be limited by the small size of clinical biopsies. Here, we isolated sr‐T cells from…”
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