Search Results - "Smith, Robin AJ"

Animal and human studies with the mitochondria-targeted antioxidant MitoQ by Smith, Robin A.J., Murphy, Michael P.

“…As mitochondrial oxidative damage contributes to a wide range of human diseases, antioxidants designed to be accumulated by mitochondria in vivo have been…”
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Targeting antioxidants to mitochondria by conjugation to lipophilic cations by MURPHY, Michael P, SMITH, Robin A. J

“…Mitochondrial oxidative damage contributes to a range of degenerative diseases. Consequently, the selective inhibition of mitochondrial oxidative damage is a…”
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Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis by Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Souza, José M., Bolatto, Carmen, Rodríguez-Bottero, Sebastián, Logan, Angela, Smith, Robin A.J., Murphy, Michael P., Barbeito, Luis, Radi, Rafael, Cassina, Patricia

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron degeneration that ultimately results in progressive…”
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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients by Gane, Edward J., Weilert, Frank, Orr, David W., Keogh, Geraldine F., Gibson, Michael, Lockhart, Michelle M., Frampton, Christopher M., Taylor, Kenneth M., Smith, Robin A. J., Murphy, Michael P.

“…Background: Increased oxidative stress and subsequent mitochondrial damage are important pathways for liver damage in chronic hepatitis C virus (HCV)…”
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MitoQuinone Rescues Aortic Endothelial Function mediated through eNOS/NO pathway by Pung, Yuh‐Fen, Kmetz, John, Bratz, Ian, Murphy, Michael P, Smith, Robin AJ, Chilian, William M

“…Abstract only Although mitochondrial oxidative stress is known to occur in many models of cardiovascular disease, whether the mitochondrial stressor alone is…”
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Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools by James, Andrew M, Cochemé, Helena M, Smith, Robin A J, Murphy, Michael P

“…Antioxidants, such as ubiquinones, are widely used in mitochondrial studies as both potential therapies and useful research tools. However, the effects of…”
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Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells by Ross, Meredith F, Prime, Tracy A, Abakumova, Irina, James, Andrew M, Porteous, Carolyn M, Smith, Robin A J, Murphy, Michael P

“…Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium) cation covalently linked to a hydrophobic bioactive moiety are used to…”
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Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry by Hoogewijs, Kurt, James, Andrew M., Smith, Robin A. J., Gait, Michael J., Murphy, Michael P., Lightowlers, Robert N.

“…Mitochondria are central to health and disease, hence there is considerable interest in developing mitochondria‐targeted therapies that require the delivery of…”
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Drug delivery to mitochondria: the key to mitochondrial medicine by Murphy, Michael P, Smith, Robin A.J

“…The major function of mitochondria in human cells is to provide ATP by oxidative phosphorylation. However, mitochondria have many other roles including the…”
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Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates by Brown, Kristin K., Blaikie, Frances H., Smith, Robin A.J., Tyndall, Joel D.A., Lue, Hongqi, Bernhagen, Jürgen, Winterbourn, Christine C., Hampton, Mark B.

“…Isothiocyanates are a class of phytochemicals with widely reported anti-cancer and anti-inflammatory activity. However, knowledge of their activity at a…”
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P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain by Porteous, Carolyn M., Menon, David K., Aigbirhio, Franklin I., Smith, Robin A.J., Murphy, Michael P.

“…Mitochondrial dysfunction contributes to degenerative neurological disorders, consequently there is a need for mitochondria-targeted therapies that are…”
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Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants by KELSO, GEOFFREY F., PORTEOUS, CAROLYN M., HUGHES, GILLIAN, LEDGERWOOD, ELIZABETH C., GANE, ALISON M., SMITH, ROBIN A. J., MURPHY, MICHAEL P.

“…Mitochondrial‐targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death have been developed. These…”
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Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN by Hobbs, Catherine E., Murphy, Michael P., Smith, Robin A.J., Oorschot, Dorothy E.

“…Background: The production of oxygen free radicals after perinatal hypoxia–ischemia is thought to play a critical role in the pathogenesis of the brain injury…”
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