Search Results - "Smith, Robin"

Targeting antioxidants to mitochondria by conjugation to lipophilic cations by MURPHY, Michael P, SMITH, Robin A. J

“…Mitochondrial oxidative damage contributes to a range of degenerative diseases. Consequently, the selective inhibition of mitochondrial oxidative damage is a…”
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Animal and human studies with the mitochondria-targeted antioxidant MitoQ by Smith, Robin A.J., Murphy, Michael P.

“…As mitochondrial oxidative damage contributes to a wide range of human diseases, antioxidants designed to be accumulated by mitochondria in vivo have been…”
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Mitochondrial pharmacology by Smith, Robin A.J, Hartley, Richard C, Cochemé, Helena M, Murphy, Michael P

“…Mitochondria are being recognized as key factors in many unexpected areas of biomedical science. In addition to their well-known roles in oxidative…”
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Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I by Chouchani, Edward T, Methner, Carmen, Nadtochiy, Sergiy M, Logan, Angela, Pell, Victoria R, Ding, Shujing, James, Andrew M, Cochemé, Helena M, Reinhold, Johannes, Lilley, Kathryn S, Partridge, Linda, Fearnley, Ian M, Robinson, Alan J, Hartley, Richard C, Smith, Robin A J, Krieg, Thomas, Brookes, Paul S, Murphy, Michael P

“…Nitric oxide donors protect from myocardial ischemia-reperfusion injury, but the underlying mechanisms have been unclear. Edward T Chouchani et al . uncover…”
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Mitochondria-targeted small molecule therapeutics and probes by Smith, Robin A J, Hartley, Richard C, Murphy, Michael P

“…Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing small…”
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A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease by Snow, Barry J., Rolfe, Fiona L., Lockhart, Michelle M., Frampton, Christopher M., O'Sullivan, John D., Fung, Victor, Smith, Robin A.J., Murphy, Michael P., Taylor, Kenneth M.

“…Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic cause for Parkinson's disease (PD). MitoQ is a powerful…”
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Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers by Pearce, Oliver M T, Delaine-Smith, Robin M, Maniati, Eleni, Nichols, Sam, Wang, Jun, Böhm, Steffen, Rajeeve, Vinothini, Ullah, Dayem, Chakravarty, Probir, Jones, Roanne R, Montfort, Anne, Dowe, Tom, Gribben, John, Jones, J Louise, Kocher, Hemant M, Serody, Jonathan S, Vincent, Benjamin G, Connelly, John, Brenton, James D, Chelala, Claude, Cutillas, Pedro R, Lockley, Michelle, Bessant, Conrad, Knight, Martin M, Balkwill, Frances R

“…We have profiled, for the first time, an evolving human metastatic microenvironment by measuring gene expression, matrisome proteomics, cytokine and chemokine…”
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Irreducible uncertainty in near-term climate projections by Hawkins, Ed, Smith, Robin S., Gregory, Jonathan M., Stainforth, David A.

“…Model simulations of the next few decades are widely used in assessments of climate change impacts and as guidance for adaptation. Their non-linear nature…”
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Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis by Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Souza, José M., Bolatto, Carmen, Rodríguez-Bottero, Sebastián, Logan, Angela, Smith, Robin A.J., Murphy, Michael P., Barbeito, Luis, Radi, Rafael, Cassina, Patricia

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron degeneration that ultimately results in progressive…”
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Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy by Graham, Delyth, Huynh, Ngan N, Hamilton, Carlene A, Beattie, Elisabeth, Smith, Robin A.J, Cochemé, Helena M, Murphy, Michael P, Dominiczak, Anna F

“…Mitochondria are a major site of reactive oxygen species production, which may contribute to the development of cardiovascular disease. Protecting mitochondria…”
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Holocene temperature conundrum by Liu, Zhengyu, Zhu, Jiang, Rosenthal, Yair, Zhang, Xu, Otto-Bliesner, Bette L, Timmermann, Axel, Smith, Robin S, Lohmann, Gerrit, Zheng, Weipeng, Elison Timm, Oliver

“…A recent temperature reconstruction of global annual temperature shows Early Holocene warmth followed by a cooling trend through the Middle to Late Holocene…”
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NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice by WALKER, Adam K, BUDAC, David P, BISULCO, Stephanie, LEE, Anna W, SMITH, Robin A, BEENDERS, Brent, KELLEY, Keith W, DANTZER, Robert

“…We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,…”
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Primary cilia respond to fluid shear stress and mediate flow‐induced calcium deposition in osteoblasts by Delaine‐Smith, Robin M., Sittichokechaiwut, Anuphan, Reilly, Gwendolen C.

“…Bone turnover in vivo is regulated by mechanical forces such as shear stress originating from interstitial oscillatory fluid flow (OFF), and bone cells in…”
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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients by Gane, Edward J., Weilert, Frank, Orr, David W., Keogh, Geraldine F., Gibson, Michael, Lockhart, Michelle M., Frampton, Christopher M., Taylor, Kenneth M., Smith, Robin A. J., Murphy, Michael P.

“…Background: Increased oxidative stress and subsequent mitochondrial damage are important pathways for liver damage in chronic hepatitis C virus (HCV)…”
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Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix by Cochemé, Helena M., Quin, Caroline, McQuaker, Stephen J., Cabreiro, Filipe, Logan, Angela, Prime, Tracy A., Abakumova, Irina, Patel, Jigna V., Fearnley, Ian M., James, Andrew M., Porteous, Carolyn M., Smith, Robin A.J., Saeed, Saima, Carré, Jane E., Singer, Mervyn, Gems, David, Hartley, Richard C., Partridge, Linda, Murphy, Michael P.

“…Hydrogen peroxide (H2O2) is central to mitochondrial oxidative damage and redox signaling, but its roles are poorly understood due to the difficulty of…”
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BioAssay Ontology (BAO): a semantic description of bioassays and high-throughput screening results by Visser, Ubbo, Abeyruwan, Saminda, Vempati, Uma, Smith, Robin P, Lemmon, Vance, Schürer, Stephan C

“…High-throughput screening (HTS) is one of the main strategies to identify novel entry points for the development of small molecule chemical probes and drugs…”
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UKESM1: Description and Evaluation of the U.K. Earth System Model by Sellar, Alistair A., Jones, Colin G., Mulcahy, Jane P., Tang, Yongming, Yool, Andrew, Wiltshire, Andy, O'Connor, Fiona M., Stringer, Marc, Hill, Richard, Palmieri, Julien, Woodward, Stephanie, Mora, Lee, Kuhlbrodt, Till, Rumbold, Steven T., Kelley, Douglas I., Ellis, Rich, Johnson, Colin E., Walton, Jeremy, Abraham, Nathan Luke, Andrews, Martin B., Andrews, Timothy, Archibald, Alex T., Berthou, Ségolène, Burke, Eleanor, Blockley, Ed, Carslaw, Ken, Dalvi, Mohit, Edwards, John, Folberth, Gerd A., Gedney, Nicola, Griffiths, Paul T., Harper, Anna B., Hendry, Maggie A., Hewitt, Alan J., Johnson, Ben, Jones, Andy, Jones, Chris D., Keeble, James, Liddicoat, Spencer, Morgenstern, Olaf, Parker, Robert J., Predoi, Valeriu, Robertson, Eddy, Siahaan, Antony, Smith, Robin S., Swaminathan, Ranjini, Woodhouse, Matthew T., Zeng, Guang, Zerroukat, Mohamed

“…We document the development of the first version of the U.K. Earth System Model UKESM1. The model represents a major advance on its predecessor HadGEM2‐ES,…”
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Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration by Qasim, Saad B, Najeeb, Shariq, Delaine-Smith, Robin M, Rawlinson, Andrew, Ur Rehman, Ihtesham

“…Graphical abstract…”
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Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells by Ross, Meredith F, Prime, Tracy A, Abakumova, Irina, James, Andrew M, Porteous, Carolyn M, Smith, Robin A J, Murphy, Michael P

“…Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium) cation covalently linked to a hydrophobic bioactive moiety are used to…”
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Microbial invasion of the Caribbean by an Indo-Pacific coral zooxanthella by Pettay, D. Tye, Drew C. Wham, Robin T. Smith, Roberto Iglesias-Prieto, Todd C. LaJeunesse

“…Human-induced environmental changes have ushered in the rapid decline of coral reef ecosystems, particularly by disrupting the symbioses between reef-building…”
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