Search Results - "Smith, Richard A.G"

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59 by Johnson, Steven, Brooks, Nicholas J., Smith, Richard A.G., Lea, Susan M., Bubeck, Doryen

“…Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen…”
Get full text

Stimulation and inhibition of fibril formation by a peptide in the presence of different concentrations of SDS by Pertinhez, Thelma A, Bouchard, Mario, Smith, Richard A.G, Dobson, Christopher M, Smith, Lorna J

“…Sodium dodecyl sulphate (SDS), a detergent that mimics some characteristics of biological membranes, has been found to affect significantly fibril formation by…”
Get full text

Structural characterization of a highly-ordered 'molten globule' at low pH by Redfield, Christina, Smith, Richard A.G, Dobson, Christopher M

“…The characterization of unfolded and partly folded states of proteins is central to understanding protein stability and folding, as well as providing a basis…”
Get full text

NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein by Penkett, Christopher J, Redfield, Christina, Dodd, Ian, Hubbard, Julia, McBay, Diane L, Mossakowska, Danuta E, Smith, Richard A.G, Dobson, Christopher M, Smith, Lorna J

“…A 130-residue fragment of the Staphylococcus aureus fibronectin-binding protein has been found to exist in a highly unfolded conformation at neutral pH…”
Get full text

Abstract 4070: Combination of Interleukin-15 with a STING (Stimulator of Interferon Gene) agonist: A potential immunotherapy for prostate cancer by Esteves, Ana M., Papaevangelou, Efthymia, Dasgupta, Prokar, Smith, Richard A.G., Galustian, Christine

“…Introduction & Objectives: Prostate cancer (PC) is the second most commonly diagnosed cancer in men and the eighth leading cause of cancer-related mortality in…”
Get full text

Generation of a Recombinant, Membrane-targeted Form of the Complement Regulator CD59 by Fraser, Deborah A., Harris, Claire L., Williams, Anwen S., Mizuno, Masashi, Gallagher, Sean, Smith, Richard A.G., Morgan, B. Paul

“…Inappropriate activation of complement contributes to pathology in diverse inflammatory diseases. Soluble recombinant forms of the natural cell membrane…”
Get full text

Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a–C3aR interaction by Peng, Qi, Li, Ke, Anderson, Katie, Farrar, Conrad A., Lu, Bao, Smith, Richard A.G., Sacks, Steven H., Zhou, Wuding

“…Donor cell expression of C3 enhances the alloimmune response and is associated with the fate of transplantation. To clarify the mechanism for enhancement of…”
Get full text

Simple Differentiation between Core-Fucosylated and Nonfucosylated Glycans by Capillary Electrophoresis by Okafo, George N., Burrow, Louise M., Neville, William, Truneh, Alem, Smith, Richard A.G., Reff, Mitchell, Camilleri, Patrick

“…Core-fucosylated glycans, derivatized with 2-aminoacridone, consistently migrate slower than the corresponding oligosaccharides which lack this fucose residue,…”
Get full text

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation by Boyd, Courtney M., Parsons, Edward S., Smith, Richard A. G., Seddon, John M., Ces, Oscar, Bubeck, Doryen

“…The plasma membrane provides an essential barrier, shielding a cell from the pressures of its external environment. Pore-forming proteins, deployed by both…”
Get full text

C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage by Duehrkop, Claudia, Banz, Yara, Spirig, Rolf, Miescher, Sylvia, Nolte, Marc W, Spycher, Martin, Smith, Richard A G, Sacks, Steven H, Rieben, Robert

“…Ischemia/reperfusion injury of lower extremities and associated lung damage may result from thrombotic occlusion, embolism, trauma, or surgical intervention…”
Get full text

Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage by PATEL, Hetal, SMITH, Richard A. G, SACKS, Steven H, WUDING ZHOU

“…A shortage of donor organs and increasing dependence on marginal grafts with prolonged ischemic times have meant that new methods are needed to prevent…”
Get full text

An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging by Pruller, Johanna, Pham, Truc Thuy, Blower, Julia E, Charoenphun, Putthiporn, Volpe, Alessia, Sunassee, Kavitha, Mullen, Gregory E. D, Blower, Philip J, Smith, Richard A. G, Ma, Michelle T

“…Cell labelling agents that enable longitudinal in vivo tracking of administered cells will support the clinical development of cell-based therapies…”
Get full text

Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation by Chen, Daxin, Li, Ke, Festenstein, Sam, Karegli, Julieta, Wilkinson, Hannah, Leonard, Hugh, Wei, Lin-Lin, Ma, Ning, Xia, Min, Tam, Henry, Wang, Jian-An, Xu, Qingbo, McVey, John H, Smith, Richard A G, Dorling, Anthony

“…Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel…”
Get full text

Abstract 2833: The protein ps20 increases tumourigenic potential in prostate cancer epithelial cells by Hickman, Oliver, Vyakarnam, Annapurna, Smith, Richard A.G., Dalgleish, Angus G., Dasgupta, Prokar, Galustian, Christine

“…Introduction The protein ps20 encoded by the WFDC1 gene contains a highly conserved whey 4-disulphide core (WFDC) domain and is a member of a protein family…”
Get full text

Abstract 4233: The protein ps20 increases resistance to docetaxel in PC3 and LNCAP prostate cancer cell lines by Galustian, Christine, Hickman, Oliver, Smith, Richard A.G., Dalgleish, Angus G., Ukimura, Osamu, Gill, Indebir S., Vyakarnam, Annapurna, Dasgupta, Prokar

“…Introduction The protein ps20 encoded by the WFDC1 gene, is a member of a protein family containing conserved whey-4-disulphide-core (WFDC) domains. Ps20 is…”
Get full text

Complement inhibition abrogates nerve terminal injury in Miller Fisher syndrome by Halstead, Susan K., Humphreys, Peter D., Goodfellow, John A., Wagner, Eric R., Smith, Richard A. G., Willison, Hugh J.

“…A large body of clinical and experimental data indicate that complement activation is an important mechanism for neuronal and glial injury in Guillain–Barré…”
Get full text

An Atomic Resolution Model for Assembly, Architecture, and Function of the Dr Adhesins by Anderson, Kirstine L., Billington, Jason, Pettigrew, David, Cota, Ernesto, Simpson, Peter, Roversi, Pietro, Chen, Ho An, Urvil, Petri, du Merle, Laurence, Barlow, Paul N., Medof, M.Edward, Smith, Richard A.G., Nowicki, Bogdan, Le Bouguénec, Chantal, Lea, Susan M., Matthews, Stephen

“…Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of…”
Get full text

Chemical methods of protein synthesis and modification by Humphries, J, Offord, R E, Smith, R A

“…Chemical and recombinant methods have continued to complement one another in the synthesis of protein analogues. Chemical methods remain particularly valuable…”
Get more information

Nontransgenic Hyperexpression of a Complement Regulator in Donor Kidney Modulates Transplant Ischemia/Reperfusion Damage, Acute Rejection, and Chronic Nephropathy by Pratt, Julian R., Jones, Miriam E., Dong, Jun, Zhou, Wuding, Chowdhury, Paramit, Smith, Richard A.G., Sacks, Steven H.

“…Complement activation during ischemia and reperfusion contributes to the development of tissue injury with severe negative impact on outcomes in…”
Get full text

Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo by Fraser, Deborah A, Harris, Claire L, Williams, Anwen S, Mizuno, Masashi, Gallagher, Sean, Smith, Richard A G, Morgan, B Paul

“…Inappropriate activation of complement contributes to pathology in diverse inflammatory diseases. Soluble recombinant forms of the natural cell membrane…”
Get full text