Search Results - "Smith, Rex Neal"

Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study by O'Connell, Philip J, MD, Zhang, Weijia, PhD, Menon, Madhav C, MD, Yi, Zhengzi, MS, Schröppel, Bernd, MD, Gallon, Lorenzo, MD, Luan, Yi, PhD, Rosales, Ivy A, MD, Ge, Yongchao, PhD, Losic, Bojan, PhD, Xi, Caixia, MS, Woytovich, Christopher, BS, Keung, Karen L, MD, Wei, Chengguo, PhD, Greene, Ilana, MS, Overbey, Jessica, MS, Bagiella, Emilia, PhD, Najafian, Nader, MD, Samaniego, Milagros, MD, Djamali, Arjang, MD, Alexander, Stephen I, MD, Nankivell, Brian J, MD, Chapman, Jeremy R, MD, Smith, Rex Neal, MD, Colvin, Robert, MD, Murphy, Barbara, Dr

“…Summary Background Chronic injury in kidney transplants remains a major cause of allograft loss. The aim of this study was to identify a gene set capable of…”
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Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys by Dehnadi, Abbas, Benedict Cosimi, A., Neal Smith, Rex, Li, Xiangen, Alonso, José L., Means, Terry K., Arnaout, M. Amin

“…Ischaemic acute kidney injury (AKI), an inflammatory disease process, often progresses to chronic kidney disease (CKD), with no available effective…”
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CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates by Kawai, Tatsuo, Sogawa, Hiroshi, Boskovic, Svetlan, Abrahamian, Gregory, Smith, Rex‐Neal, Wee, Siew‐Lin, Andrews, David, Nadazdin, Ognjenka, Koyama, Ichiro, Sykes, Megan, Winn, Henry J., Colvin, Robert B., Sachs, David H., Cosimi, A. Benedict

“…Costimulatory blockade with anti‐CD154 monoclonal antibody (aCD154) prolongs allograft survival in nonhuman primates, but has not reliably induced tolerance…”
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A Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation by Sommer, Wiebke, O, Jane M., Pruner, Kurt B., Dehnadi, Abbas, Ha Huh, Kyu, Robinson, Kortney A., Hanekamp, Isabel, Rosales, Ivy, Bean, Alison S., Paster, Josh, Oura, Tetsu, Neal Smith, Rex, Colvin, Robert, Benichou, Gilles, Kawai, Tatsuo, Madsen, Joren C., Allan, James S.

“…In kidney transplantation, long-term allograft acceptance in cynomolgus macaques was achieved using a mixed-chimerism protocol based on the clinically…”
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Stem Cell Mobilization and Collection for Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys by Nadazdin, Ognjenka, M.D, Abrahamian, Gregory, M.D, Boskovic, Svjetlan, M.D, Smith, Rex-Neal, M.D, Schoenfeld, David A., Ph.D, Madsen, Joren C., M.D., D. Phil, Colvin, Robert B., M.D, Sachs, David H., M.D, Cosimi, A. Benedict, M.D, Kawai, Tatsuo, M.D., Ph.D

“…Background We have previously observed that donor bone marrow hematopoietic stem cells successfully induce transient mixed chimerism and renal allograft…”
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Long-term Kinetics of Intragraft Gene Signatures in Renal Allograft Tolerance Induced by Transient Mixed Chimerism by Matsunami, Masatoshi, Rosales, Ivy A, Adam, Benjamin A, Oura, Tetsu, Mengel, Michael, Smith, Rex-Neal, Lee, Hang, Cosimi, A Benedict, Colvin, Robert B, Kawai, Tatsuo

“…BACKGROUND.Renal allograft tolerance (TOL) has been successfully induced in nonhuman primates (NHPs) and humans through the induction of transient mixed…”
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Anti―LAMP-2 Antibodies Are Not Prevalent in Patients With Antineutrophil Cytoplasmic Autoantibody Glomerulonephritis by ROTH, Aleeza J, BROWN, Michael C, YANG, Jia-Jin, BERG, Elisabeth A, NILES, John, CHARLES JENNETTE, J, PRESTON, Gloria A, FALK, Ronald J, NEAL SMITH, Rex, BADHWAR, Anshul K, PARENTE, Oscar, CHUL CHUNG, Hyun, O'DELL BUNCH, Donna, MCGREGOR, Julieanne G, HOGAN, Susan L, YICHUN HU

“…Lysosomal membrane protein 2 (LAMP-2) is a target of antineutrophil cytoplasmic autoantibodies (ANCA) in addition to the more commonly known targets proteinase…”
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Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates by Nadazdin, Ognjenka, Boskovic, Svjetlan, Murakami, Toru, Tocco, Georges, Smith, Rex-Neal, Colvin, Robert B, Sachs, David H, Allan, James, Madsen, Joren C, Kawai, Tatsuo, Cosimi, A Benedict, Benichou, Gilles

“…Transplant tolerance, defined as indefinite allograft survival without immunosuppression, has been regularly achieved in laboratory mice but not in nonhuman…”
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Induced regulatory T cells in allograft tolerance via transient mixed chimerism by Hotta, Kiyohiko, Aoyama, Akihiro, Oura, Tetsu, Yamada, Yohei, Tonsho, Makoto, Huh, Kyu Ha, Kawai, Kento, Schoenfeld, David, Allan, James S, Madsen, Joren C, Benichou, Gilles, Smith, Rex-Neal, Colvin, Robert B, Sachs, David H, Cosimi, A Benedict, Kawai, Tatsuo

“…Successful induction of allograft tolerance has been achieved in nonhuman primates (NHPs) and humans via induction of transient hematopoietic chimerism. Since…”
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Increased transfusion-free survival following auxiliary pig liver xenotransplantation by Yeh, Heidi, Machaidze, Zurab, Wamala, Isaac, Fraser, James W., Navarro-Alvarez, Nalu, Kim, Karen, Schuetz, Christian, Shi, Shuai, Zhu, Alexander, Hertl, Martin, Elias, Nahel, Farkash, Evan A., Vagefi, Parsia A., Varma, Manish, Smith, Rex Neal, Robson, Simon C., Van Cott, Elizabeth M., Sachs, David H., Markmann, James F.

“…Background Pig to baboon liver xenotransplantation typically results in severe thrombocytopenia and coagulation disturbances, culminating in death from…”
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Role of CXC chemokine receptor 3 pathway in renal ischemic injury by FIORINA, Paolo, MOHAMMED JAVEED ANSARI, SAYEGH, Mohamed H, ABDI, Reza, JUREWICZ, Mollie, BARRY, Mark, RICCHIUTI, Vincent, SMITH, Rex Neal, SHEA, Susan, MEANS, Terry K, AUCHINCLOSS, Hugh, LUSTER, Andrew D

“…Chemokines play a major role in the recruitment of leukocytes in inflammation and in the regulation of T helper 1 (Th1)/Th2 immune responses. These mechanisms…”
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Prolonged survival of GalT-KO swine skin on baboons by Weiner, Joshua, Yamada, Kazuhiko, Ishikawa, Yoshinori, Moran, Shannon, Etter, Justin, Shimizu, Akira, Neal Smith, Rex, Sachs, David H.

“…Weiner J, Yamada K, Ishikawa Y, Moran S, Etter J, Shimizu A, Smith RN, Sachs DH. Prolonged survival of GalT‐KO swine skin on baboons. Xenotransplantation 2010;…”
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Lung allograft tolerance in non-human primates following delayed donor bone marrow transplantation by Lee, Soyoung, MD, FRCSG, Aoyama, Akihiro, MD, Tonsho, Makoto, MD, Boskovic, Svjetlan, MD, Smith, Rex Neal, MD, Cosimi, A. Benedict, MD, FACS, Madsen, Joren C., MD, PhD, FACS, Benichou, Gilles, MD, Kawai, Tatsuo, MD, FACS, Allan, James S., MD, FACS

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Renal allograft tolerance can be achieved in non-human primates via delayed mixed-hematopoietic chimerism and alefacept treatment by Lee, Soyoung, MD, Yamada, Yohei, MD, Tonsho, Makoto, MD, Boskovic, Svjetlan, MD, Smith, Rex Neal, MD, Colvin, Robert B., MD, Madsen, Joren C., MD, PhD, FACS, Cosimi, A. Benedict, MD, FACS, Benichou, Gilles, MD, Kawai, Tatsuo, MD, FACS

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Importance of donor-and recipient-derived selectins in cardiac allograft rejection by IZAWA, Atsushi, UENO, Takuya, HYNES, Richard O, ABDI, Reza, JUREWICZ, Mollie, ITO, Toshiro, TANAKA, Katsunori, TAKAHASHI, Masafumi, IKEDA, Uichi, SOBOLEV, Olga, FIORINA, Paolo, NEAL SMITH, Rex

“…The selectins expressed on activated endothelial cells (E- and P-selectin), leukocytes (L-selectin), and platelets (P-selectin) play crucial roles in the…”
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Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates by BOSKOVIC, Svjetlan, KAWAI, Tatsuo, STROM, Terry, COLVIN, Robert B, SACHS, David H, COSIMI, A. Benedict, SMITH, Rex-Neal, WEE, Siew-Lin, NADAZDIN, Ognjenka, KOYAMA, Ichiro, SAIDMAN, Susan, CARDARELLI, Francesca, ELIAS, Nahel, SYKES, Megan

“…In an effort to define reliable assays that might predict postimmunosuppressant-withdrawal development of chronic rejection (CR), despite conditioning for…”
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Banff 2013 Meeting Report: Inclusion of C4d‐Negative Antibody‐Mediated Rejection and Antibody‐Associated Arterial Lesions by Haas, M., Sis, B., Racusen, L. C., Solez, K., Glotz, D., Colvin, R. B., Castro, M. C. R., David, D. S. R., David‐Neto, E., Bagnasco, S. M., Cendales, L. C., Cornell, L. D., Demetris, A. J., Drachenberg, C. B., Farver, C. F., Farris, A. B., Gibson, I. W., Kraus, E., Liapis, H., Loupy, A., Nickeleit, V., Randhawa, P., Rodriguez, E. R., Rush, D., Smith, R. N., Tan, C. D., Wallace, W. D., Mengel, M.

“…The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19–23, 2013, and was preceded by a 2‐day Latin American Symposium…”
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Histologic and molecular features of antibody-mediated rejection by Rosales, Ivy A, Smith, Rex Neal, Colvin, Robert B

“…This review aims to summarize the highlights from recent research that involved pathological and molecular analysis of kidney allografts. As the research on…”
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Banff Human Organ Transplant Transcripts Correlate with Renal Allograft Pathology and Outcome: Importance of Capillaritis and Subpathologic Rejection by Rosales, Ivy A, Mahowald, Grace K, Tomaszewski, Kristen, Hotta, Kiyohiko, Iwahara, Naoya, Otsuka, Takuya, Tsuji, Takahiro, Takada, Yusuke, Acheampong, Ellen, Araujo-Medina, Milagros, Bruce, Amy, Rios, Andrea, Cosimi, Anthony Benedict, Elias, Nahel, Kawai, Tatsuo, Gilligan, Hannah, Safa, Kassem, Riella, Leonardo V, Tolkoff-Rubin, Nina E, Williams, Jr, Winfred W, Smith, Rex Neal, Colvin, Robert B

“…To seek insights into the pathogenesis of chronic active antibody-mediated rejection (CAMR), we performed mRNA analysis and correlated transcripts with…”
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A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection by Zhang, Weijia, Yi, Zhengzi, Keung, Karen L, Shang, Huimin, Wei, Chengguo, Cravedi, Paolo, Sun, Zeguo, Xi, Caixia, Woytovich, Christopher, Farouk, Samira, Huang, Weiqing, Banu, Khadija, Gallon, Lorenzo, Magee, Ciara N, Najafian, Nader, Samaniego, Milagros, Djamali, Arjang, Alexander, Stephen I, Rosales, Ivy A, Smith, Rex Neal, Xiang, Jenny, Lerut, Evelyne, Kuypers, Dirk, Naesens, Maarten, O'Connell, Philip J, Colvin, Robert, Menon, Madhav C, Murphy, Barbara

“…In kidney transplant recipients, surveillance biopsies can reveal, despite stable graft function, histologic features of acute rejection and borderline changes…”
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