Search Results - "Smith, Reuben L"

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease by Smith, Reuben L, Soeters, Maarten R, Wüst, Rob C I, Houtkooper, Riekelt H

“…Abstract The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is…”
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A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans by Gao, Arwen W., Chatzispyrou, Iliana A., Kamble, Rashmi, Liu, Yasmine J., Herzog, Katharina, Smith, Reuben L., van Lenthe, Henk, Vervaart, Martin A. T., van Cruchten, Arno, Luyf, Angela C., van Kampen, Antoine, Pras-Raves, Mia L., Vaz, Frédéric M., Houtkooper, Riekelt H.

“…Abnormal nutrient metabolism is a hallmark of aging, and the underlying genetic and nutritional framework is rapidly being uncovered, particularly using C…”
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Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity by Smith, Reuben L, Tan, Josephine M E, Jonker, Martijs J, Jongejan, Aldo, Buissink, Thomas, Veldhuijzen, Steve, van Kampen, Antoine H C, Brul, Stanley, van der Spek, Hans

“…Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their…”
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Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans by Liu, Yasmine J., Gao, Arwen W., Smith, Reuben L., Janssens, Georges E., Panneman, Daan M., Jongejan, Aldo, van Weeghel, Michel, Vaz, Frédéric M., Silvestrini, Melissa J., Lapierre, Louis R., MacInnes, Alyson W., Houtkooper, Riekelt H.

“…Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the…”
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Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy by Pryor, Rosina, Norvaisas, Povilas, Marinos, Georgios, Best, Lena, Thingholm, Louise B., Quintaneiro, Leonor M., De Haes, Wouter, Esser, Daniela, Waschina, Silvio, Lujan, Celia, Smith, Reuben L., Scott, Timothy A., Martinez-Martinez, Daniel, Woodward, Orla, Bryson, Kevin, Laudes, Matthias, Lieb, Wolfgang, Houtkooper, Riekelt H., Franke, Andre, Temmerman, Liesbet, Bjedov, Ivana, Cochemé, Helena M., Kaleta, Christoph, Cabreiro, Filipe

“…Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address the fundamental question of how gut…”
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Identification of key pathways and metabolic fingerprints of longevity in C. elegans by Gao, Arwen W., Smith, Reuben L., van Weeghel, Michel, Kamble, Rashmi, Janssens, Georges E., Houtkooper, Riekelt H.

“…Impaired insulin/IGF-1 signaling (IIS) and caloric restriction (CR) prolong lifespan in the nematode C. elegans. However, a cross comparison of these longevity…”
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Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation by Molenaars, Marte, Schomakers, Bauke V, Elfrink, Hyung L, Gao, Arwen W, Vervaart, Martin A T, Pras-Raves, Mia L, Luyf, Angela C, Smith, Reuben L, Sterken, Mark G, Kammenga, Jan E, van Kampen, Antoine H C, Janssens, Georges E, Vaz, Frédéric M, van Weeghel, Michel, Houtkooper, Riekelt H

“…Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand; for instance, in research related to nutrition and aging. The…”
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Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans by Gao, Arwen W., uit de Bos, Jelmi, Sterken, Mark G., Kammenga, Jan E., Smith, Reuben L., Houtkooper, Riekelt H.

“…The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated…”
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Developmental drift as a mechanism for aging: lessons from nematodes by Lezzerini, Marco, Smith, Reuben L., Budovskaya, Yelena

“…Aging is a universal biological process that afflicts every creature on this planet. To date, we have a very poor understanding of what actually causes this…”
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Premature and accelerated aging: HIV or HAART? by Smith, Reuben L, de Boer, Richard, Brul, Stanley, Budovskaya, Yelena, van Spek, Hans

“…Highly active antiretroviral therapy (HAART) has significantly increased life expectancy of the human immunodeficiency virus (HIV)-positive population…”
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In vivo visualization and quantification of mitochondrial morphology in C. elegans by Smith, Reuben L, De Vos, Winnok H, de Boer, Richard, Manders, Erik M M, van der Spek, Hans

“…Caenorhabditis elegans is a highly malleable model system, intensively used for functional, genetic, cytometric, and integrative studies. Due to its simplicity…”
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Beyond the polymerase-[gamma] theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity by Smith, Reuben L, Tan, Josephine M. E, Jonker, Martijs J, Jongejan, Aldo, Buissink, Thomas, Veldhuijzen, Steve, van Kampen, Antoine H. C, Brul, Stanley, van der Spek, Hans

“…Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their…”
Get full text