Search Results - "Smith, Paula J.W"
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Aerobic fitness is associated with lower proportions of senescent blood T-cells in man
Published in Brain, behavior, and immunity (01-11-2011)“…Highlight ► Aerobic fitness is associated with lower proportions of senescent T-cells independently of age, highlighting the beneficial effects of fitness on…”
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Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats
Published in European journal of pharmacology (03-05-2004)“…The results of vasorespiratory studies in rats anaesthetised with pentobarbital show that (±) cannabidiol, a cannabinoid that lacks psychotropic actions and is…”
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Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anaesthetised rats
Published in Neuroscience research (01-11-2004)“…In the present study we measured cardiovascular and respiratory reflexes evoked by administration of bradykinin and capsaicin into the hindlimb vasculature of…”
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Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos
Published in Toxicology in vitro (01-10-2015)“…•MWCNTs were synthesised with specific physicochemical characteristics.•Particle characteristics known to induce respiratory disease were assessed: length,…”
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Evaluation of an Educational Scholarship Fellowship Program for Health Professions Educators
Published in Medical science educator (01-08-2024)“…Introduction Historically, the requirement to produce scholarship for advancement has challenged health professions educators heavily engaged in teaching. As…”
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The value of reviewer diversity and inclusivity
Published in The clinical teacher (01-02-2022)Get full text
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Distance Learning Improves Attainment of Professional Milestones in the Early Years of Surgical Training
Published in Annals of surgery (01-11-2013)“…OBJECTIVES:To assess the impact of a surgical sciences e-learning programme in supporting the academic development of surgical trainees during their…”
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Expression of cannabinoid CB1 receptors in models of diabetic neuropathy
Published in The Journal of pharmacology and experimental therapeutics (01-11-2007)“…A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the…”
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Cannabinoid CB 1 receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced Ca 2+ influx in an in vitro model of diabetic neuropathy
Published in Neuropharmacology (2009)“…Cannabinoid CB 1 receptors mediate, in part, the neuroprotectant properties of endocannabinoids, and altered signalling via the CB 1 receptor may contribute to…”
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Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat
Published in British journal of pharmacology (01-10-2001)“…We tested the hypothesis that sensory nerves innervating blood vessels play a role in the local and systemic regulation of the cardiovascular and respiratory…”
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Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats
Published in Circulation (New York, N.Y.) (12-12-2000)“…Estrogen may increase the long-term survival of women who have suffered from a myocardial infarction (MI). We examined the acute and chronic influence of…”
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Quantification of endothelin receptor mRNA by competitive RT-PCR
Published in Methods in molecular biology (Clifton, N.J.) (2002)Get more information
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Coordinated Upregulation of the Cardiac Endothelin System in a Rat Model of Heart Failure
Published in Journal of cardiovascular pharmacology (1998)“…The potent vascular, cardiac, and renal actions of endothelin-1 (ET-1) suggest a role for this vasoconstrictor peptide in the pathophysiology of heart failure…”
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Impaired cholinergic dilator response of resistance arteries isolated from patients with Raynaud’s disease
Published in British journal of clinical pharmacology (01-05-1999)“…Aims We examined the effect of cooling on the response to the endothelium‐dependent and ‐independent dilators, acetylcholine (ACh) and sodium nitroprusside…”
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Regulation of Endothelin-B Receptor mRNA Expression in Human Endothelial Cells by Cytokines and Growth Factors
Published in Journal of cardiovascular pharmacology (1998)“…The regulation of endothelin-B receptor (ETB) mRNA expression in human endothelial cells (ECs) by cytokines and growth factors may play an important role in…”
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Expression of Endothelial Factors After Arterial Injury in the Rat
Published in Journal of cardiovascular pharmacology (1998)“…Endothelin-1 (ET-1) and nitric oxide (NO) are potent vasoactive factors known to play a role in vascular remodeling. This study assessed the temporal…”
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Functional Studies in Small Arteries Do Not Support a Primary Role for Endothelin in the Pathogenesis of Raynaud's Disease
Published in Journal of cardiovascular pharmacology (1998)“…Endothelin-1(ET-1) has been implicated in the pathogenesis of Raynaud's disease (RD). This study examined the effect of cooling on the response to ET-1 in…”
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