Search Results - "Smith, Michelle I."

Gut DNA viromes of Malawian twins discordant for severe acute malnutrition by Reyes, Alejandro, Blanton, Laura V., Cao, Song, Zhao, Guoyan, Manary, Mark, Trehan, Indi, Smith, Michelle I., Wang, David, Virgin, Herbert W., Rohwer, Forest, Gordon, Jeffrey I.

“…The bacterial component of the human gut microbiota undergoes a definable program of postnatal development. Evidence is accumulating that this program is…”
Get full text

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor by Smith, Michelle I., Yatsunenko, Tanya, Manary, Mark J., Trehan, Indi, Mkakosya, Rajhab, Cheng, Jiye, Kau, Andrew L., Rich, Stephen S., Concannon, Patrick, Mychaleckyj, Josyf C., Liu, Jie, Houpt, Eric, Li, Jia V., Holmes, Elaine, Nicholson, Jeremy, Knights, Dan, Ursell, Luke K., Knight, Rob, Gordon, Jeffrey I.

“…Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To…”
Get full text

Bacteria from Diverse Habitats Colonize and Compete in the Mouse Gut by Seedorf, Henning, Griffin, Nicholas W., Ridaura, Vanessa K., Reyes, Alejandro, Cheng, Jiye, Rey, Federico E., Smith, Michelle I., Simon, Gabriel M., Scheffrahn, Rudolf H., Woebken, Dagmar, Spormann, Alfred M., Van Treuren, William, Ursell, Luke K., Pirrung, Megan, Robbins-Pianka, Adam, Cantarel, Brandi L., Lombard, Vincent, Henrissat, Bernard, Knight, Rob, Gordon, Jeffrey I.

“…To study how microbes establish themselves in a mammalian gut environment, we colonized germ-free mice with microbial communities from human, zebrafish, and…”
Get full text

Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients by Power, Namita, Turpin, Williams, Espin-Garcia, Osvaldo, Smith, Michelle I, Croitoru, Kenneth

“…Intestinal epithelial cell tight junctions (TJs) contribute to the integrity of the intestinal barrier allowing for control of the physical barrier between…”
Get full text

Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn’s disease subjects by Turpin, Williams, Bedrani, Larbi, Espin-Garcia, Osvaldo, Xu, Wei, Silverberg, Mark S., Smith, Michelle I., Garay, Juan Antonio Raygoza, Lee, Sun-Ho, Guttman, David S., Griffiths, Anne, Moayyedi, Paul, Panaccione, Remo, Huynh, Hien, Steinhart, Hillary A., Aumais, Guy, Dieleman, Levinus A., Turner, Dan, Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Levinus, Feagan, Brian, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Seidman, Ernest, Silverberg, Mark, Stadnyk, Andy, Steinhart, A. Hillary, Surette, Michael, Walters, Thomas, Vallance, Bruce, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Baldassano, Robert, Griffiths, Anne M., Hedin, Charlotte, Hussey, Seamus, Hyams, Hien, Keljo, David, Kevans, David, Lees, Charlie, Murthy, Sanjay, Parekh, Nimisha, Plamondon, Sophie, Radford-Smith, Graham, Ropeleski, Mark, Rosh, Joel, Rubin, David, Schultz, Michael, Siegel, Corey, Snapper, Scott, Paterson, Andrew D., Croitoru, Kenneth

“…Abstract Background Genetic analyses have identified many variants associated with the risk of inflammatory bowel disease (IBD) development. Among these…”
Get full text

Chromatin Modification of Apaf-1 Restricts the Apoptotic Pathway in Mature Neurons by Wright, Kevin M., Smith, Michelle I., Farrag, Lila, Deshmukh, Mohanish

“…Although apoptosis has been extensively studied in developing neurons, the dynamic changes in this pathway after neuronal maturation remain largely unexplored…”
Get full text

Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues by Johnson, Carrie E, Huang, Yolanda Y, Parrish, Amanda B, Smith, Michelle I, Vaughn, Allyson E, Zhang, Qian, Wright, Kevin M, Van Dyke, Terry, Wechsler-Reya, Robert J, Kornbluth, Sally, Deshmukh, Mohanish

“…Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In…”
Get full text

Association of host genome with intestinal microbial composition in a large healthy cohort by Turpin, Williams, Espin-Garcia, Osvaldo, Xu, Wei, Silverberg, Mark S, Kevans, David, Smith, Michelle I, Guttman, David S, Griffiths, Anne, Panaccione, Remo, Otley, Anthony, Xu, Lizhen, Shestopaloff, Konstantin, Moreno-Hagelsieb, Gabriel, Paterson, Andrew D, Croitoru, Kenneth

“…Kenneth Croitoru, Andrew Paterson and colleagues perform genome-wide association analysis for gut microbiome composition. They identify 58 SNPs significantly…”
Get full text

Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease by Turpin, Williams, Lee, Sun-Ho, Raygoza Garay, Juan Antonio, Madsen, Karen L., Meddings, Jonathan B., Bedrani, Larbi, Power, Namita, Espin-Garcia, Osvaldo, Xu, Wei, Smith, Michelle I., Griffiths, Anne M., Moayyedi, Paul, Turner, Dan, Seidman, Ernest G., Steinhart, A. Hillary, Marshall, John K., Jacobson, Kevan, Mack, David, Huynh, Hien, Bernstein, Charles N., Paterson, Andrew D., Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Baldassano, Robert, Griffiths, Anne M., Hedin, Charlotte, Hussey, Seamus, Hyams, Hien, Keljo, David, Kevans, David, Lees, Charlie, Murthy, Sanjay, Panaccione, Remo, Parekh, Nimisha, Plamondon, Sophie, Radford-Smith, Graham, Rosh, Joel, Rubin, David, Schultz, Michael, Siegel, Corey, Turner, Dan, Croitoru, Kenneth

“…Increased intestinal permeability has been associated with Crohn’s disease (CD), but it is not clear whether it is a cause or result of the disease. We…”
Get full text

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis by Galipeau, Heather J., Caminero, Alberto, Turpin, Williams, Bermudez-Brito, Miriam, Santiago, Alba, Libertucci, Josie, Constante, Marco, Raygoza Garay, Juan Antonio, Rueda, Gaston, Armstrong, Sarah, Clarizio, Alex, Smith, Michelle I., Surette, Michael G., Bercik, Premysl, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Croitoru, Kenneth, Verdu, Elena F.

“…Altered gut microbiota composition and function have been associated with inflammatory bowel diseases, including ulcerative colitis (UC), but the causality and…”
Get full text

Analyzing the human microbiome: a "how to" guide for physicians by Tyler, Andrea D, Smith, Michelle I, Silverberg, Mark S

“…The application of high-throughput next-generation sequencing to the analysis of the human microbiome has led to a shift in our understanding of the etiology…”
Get full text

Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives by Raygoza Garay, Juan Antonio, Turpin, Williams, Lee, Sun-Ho, Smith, Michelle I., Goethel, Ashleigh, Griffiths, Anne M., Moayyedi, Paul, Espin-Garcia, Osvaldo, Abreu, Maria, Aumais, Guy L., Bernstein, Charles N., Biron, Irit A., Cino, Maria, Deslandres, Colette, Dotan, Iris, El-Matary, Wael, Feagan, Brian, Guttman, David S., Huynh, Hien, Dieleman, Levinus A., Hyams, Jeffrey S., Jacobson, Kevan, Mack, David, Marshall, John K., Otley, Anthony, Panaccione, Remo, Ropeleski, Mark, Silverberg, Mark S., Steinhart, A. Hillary, Turner, Dan, Yerushalmi, Baruch, Paterson, Andrew D., Xu, Wei, Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Levinus A., Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeffrey S., Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Croitoru, Kenneth

“…The cause of Crohn’s disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically…”
Get full text

Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease by Leibovitzh, Haim, Lee, Sun-Ho, Xue, Mingyue, Raygoza Garay, Juan Antonio, Hernandez-Rocha, Cristian, Madsen, Karen L., Meddings, Jonathan B., Guttman, David S., Espin-Garcia, Osvaldo, Smith, Michelle I., Goethel, Ashleigh, Griffiths, Anne M., Moayyedi, Paul, Steinhart, A. Hillary, Panaccione, Remo, Huynh, Hien Q., Jacobson, Kevan, Aumais, Guy, Mack, David R., Abreu, Maria T., Bernstein, Charles N., Marshall, John K., Turner, Dan, Xu, Wei, Turpin, Williams, Croitoru, Kenneth

“…The gut microbiome has been suggested to play a role in gut barrier hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess…”
Get full text

Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk by Lee, Sun-Ho, Turpin, Williams, Espin-Garcia, Osvaldo, Raygoza Garay, Juan Antonio, Smith, Michelle I., Leibovitzh, Haim, Goethel, Ashleigh, Turner, Dan, Mack, David, Deslandres, Colette, Cino, Maria, Aumais, Guy, Panaccione, Remo, Jacobson, Kevan, Bitton, Alain, Steinhart, A. Hillary, Huynh, Hien Q., Princen, Fred, Moayyedi, Paul, Griffiths, Anne M., Silverberg, Mark S., Paterson, Andrew D., Xu, Wei, Croitoru, Kenneth

“…Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn’s disease (CD). We aimed to assess whether increased serum…”
Get full text

CORE-IBD: A Multidisciplinary International Consensus Initiative to Develop a Core Outcome Set for Randomized Controlled Trials in Inflammatory Bowel Disease by Ma, Christopher, Hanzel, Jurij, Panaccione, Remo, Sandborn, William J., D’Haens, Geert R., Ahuja, Vineet, Atreya, Raja, Bernstein, Charles N., Bossuyt, Peter, Bressler, Brian, Bryant, Robert V., Cohen, Benjamin, Colombel, Jean-Frederic, Danese, Silvio, Dignass, Axel, Dubinsky, Marla C., Fleshner, Phillip R., Gearry, Richard B., Hanauer, Stephen B., Hart, Ailsa, Kotze, Paulo Gustavo, Kucharzik, Torsten, Lakatos, Peter L., Leong, Rupert W., Magro, Fernando, Panés, Julian, Peyrin-Biroulet, Laurent, Ran, Zhihua, Regueiro, Miguel, Singh, Siddharth, Spinelli, Antonino, Steinhart, A. Hillary, Travis, Simon P., van der Woude, C. Janneke, Yacyshyn, Bruce, Yamamoto, Takayuki, Allez, Matthieu, Bemelman, Willem A., Lightner, Amy L., Louis, Edouard, Rubin, David T., Scherl, Ellen J., Siegel, Corey A., Silverberg, Mark S., Vermeire, Severine, Parker, Claire E., McFarlane, Stefanie C., Guizzetti, Leonardo, Smith, Michelle I., Vande Casteele, Niels, Feagan, Brian G., Jairath, Vipul

“…End points to determine the efficacy and safety of medical therapies for Crohn’s disease (CD) and ulcerative colitis (UC) are evolving. Given the heterogeneity…”
Get full text

Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation by Turpin, Williams, Dong, Mei, Sasson, Gila, Raygoza Garay, Juan Antonio, Espin-Garcia, Osvaldo, Lee, Sun-Ho, Neustaeter, Anna, Smith, Michelle I., Leibovitzh, Haim, Guttman, David S., Goethel, Ashleigh, Griffiths, Anne M., Huynh, Hien Q., Dieleman, Levinus A., Panaccione, Remo, Steinhart, A. Hillary, Silverberg, Mark S., Aumais, Guy, Jacobson, Kevan, Mack, David, Murthy, Sanjay K., Marshall, John K., Bernstein, Charles N., Abreu, Maria T., Moayyedi, Paul, Paterson, Andrew D., Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Baldassano, Robert, Griffiths, Anne M., Hedin, Charlotte, Hussey, Seamus, Hyams, Hien, Keljo, David, Kevans, David, Lees, Charlie, Murthy, Sanjay, Panaccione, Remo, Parekh, Nimisha, Plamondon, Sophie, Radford-Smith, Graham, Rosh, Joel, Rubin, David, Schultz, Michael, Siegel, Corey, Xu, Wei, Croitoru, Kenneth

“…Case-control studies have shown that patients with Crohn’s disease (CD) have a microbial composition different from healthy individuals. Although the causes of…”
Get full text

Persistent Diarrhea in Patients With Crohn’s Disease After Mucosal Healing Is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis by Boland, Karen, Bedrani, Larbi, Turpin, Williams, Kabakchiev, Boyko, Stempak, Joanne, Borowski, Krzysztof, Nguyen, Geoffrey, Steinhart, A. Hillary, Smith, Michelle I., Croitoru, Kenneth, Silverberg, Mark S.

“…In patients with inflammatory bowel diseases (IBDs), symptoms do not always associate with the severity of endoscopic inflammation and can persist after…”
Get full text

Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway by Smith, Michelle I, Huang, Yolanda Y, Deshmukh, Mohanish

“…Myotube apoptosis occurs normally during muscle development and aging but it can lead to destruction of skeletal muscle in neuromuscular diseases. Therefore,…”
Get full text

Differential miRNA Expression in Ileal and Colonic Tissues Reveals an Altered Immunoregulatory Molecular Profile in Individuals With Crohn's Disease versus Healthy Subjects by Mohammadi, Aylia, Kelly, Orlaith B, Smith, Michelle I, Kabakchiev, Boyko, Silverberg, Mark S

“…MicroRNAs [miRNAs] are key modulators of gene expression in Crohn's disease [CD] and may drive tissue-specific molecular alterations underlying CD…”
Get full text

Differential Expression of microRNAs in Peripheral Blood Mononuclear Cells Identifies Autophagy and TGF-Beta-Related Signatures Aberrantly Expressed in Inflammatory Bowel Disease by Mohammadi, Aylia, Kelly, Orlaith B, Filice, Melissa, Kabakchiev, Boyko, Smith, Michelle I, Silverberg, Mark S

“…Abstract Background and Aims MicroRNAs [miRNAs] have emerged as important regulators in inflammatory bowel disease [IBD]. This study investigated differential…”
Get full text