Search Results - "Smith, Michelle E."

Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players by Bondurand, Nadege, Southard-Smith, E. Michelle

“…Hirschsprung disease (HSCR, intestinal aganglionosis) is a multigenic disorder with variable penetrance and severity that has a general population incidence of…”
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Insights into olfactory ensheathing cell development from a laser‐microdissection and transcriptome‐profiling approach by Perera, Surangi N., Williams, Ruth M., Lyne, Rachel, Stubbs, Oliver, Buehler, Dennis P., Sauka‐Spengler, Tatjana, Noda, Masaharu, Micklem, Gos, Southard‐Smith, E. Michelle, Baker, Clare V. H.

“…Olfactory ensheathing cells (OECs) are neural crest‐derived glia that ensheath bundles of olfactory axons from their peripheral origins in the olfactory…”
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Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells by Dravis, Christopher, Spike, Benjamin T., Harrell, J. Chuck, Johns, Claire, Trejo, Christy L., Southard-Smith, E. Michelle, Perou, Charles M., Wahl, Geoffrey M.

“…To discover mechanisms that mediate plasticity in mammary cells, we characterized signaling networks that are present in the mammary stem cells responsible for…”
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The GUDMAP database--an online resource for genitourinary research by Harding, Simon D, Armit, Chris, Armstrong, Jane, Brennan, Jane, Cheng, Ying, Haggarty, Bernard, Houghton, Derek, Lloyd-MacGilp, Sue, Pi, Xingjun, Roochun, Yogmatee, Sharghi, Mehran, Tindal, Christopher, McMahon, Andrew P, Gottesman, Brian, Little, Melissa H, Georgas, Kylie, Aronow, Bruce J, Potter, S Steven, Brunskill, Eric W, Southard-Smith, E Michelle, Mendelsohn, Cathy, Baldock, Richard A, Davies, Jamie A, Davidson, Duncan

“…The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an international consortium working to generate gene expression data and transgenic mice…”
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Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis by Kulkarni, Subhash, Micci, Maria-Adelaide, Leser, Jenna, Shin, Changsik, Tang, Shiue-Cheng, Fu, Ya-Yuan, Liu, Liansheng, Li, Qian, Saha, Monalee, Li, Cuiping, Enikolopov, Grigori, Becker, Laren, Rakhilin, Nikolai, Anderson, Michael, Shen, Xiling, Dong, Xinzhong, Butte, Manish J., Song, Hongjun, Southard-Smith, E. Michelle, Kapur, Raj P., Bogunovic, Milena, Pasricha, Pankaj J.

“…According to current dogma, there is little or no ongoing neurogenesis in the fully developed adult enteric nervous system. This lack of neurogenesis leaves…”
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Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting by Rich, Constance A., Perera, Surangi N., Andratschke, Jacqueline, Stolt, C. Claus, Buehler, Dennis P., Southard‐Smith, E. Michelle, Wegner, Michael, Britsch, Stefan, Baker, Clare V. H.

“…We and others previously showed that in mouse embryos lacking the transcription factor Sox10, olfactory ensheathing cell (OEC) differentiation is disrupted,…”
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Migration pathways of sacral neural crest during development of lower urogenital tract innervation by Wiese, Carrie B., Deal, Karen K., Ireland, Sara J., Cantrell, V. Ashley, Southard-Smith, E. Michelle

“…The migration and fate of cranial and vagal neural crest-derived progenitor cells (NCPCs) have been extensively studied; however, much less is known about…”
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Combinatorial Transcriptional Profiling of Mouse and Human Enteric Neurons Identifies Shared and Disparate Subtypes In Situ by May-Zhang, Aaron A., Tycksen, Eric, Southard-Smith, Austin N., Deal, Karen K., Benthal, Joseph T., Buehler, Dennis P., Adam, Mike, Simmons, Alan J., Monaghan, James R., Matlock, Brittany K., Flaherty, David K., Potter, S. Steven, Lau, Ken S., Southard-Smith, E. Michelle

“…The enteric nervous system (ENS) coordinates essential intestinal functions through the concerted action of diverse enteric neurons (ENs). However, integrated…”
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RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development by Chan, Wing Hei, Komada, Masayuki, Fukushima, Toshiaki, Southard-Smith, E. Michelle, Anderson, Colin R., Wakefield, Matthew J.

“…Adrenal chromaffin cells and sympathetic neurons synthesize and release catecholamines, and both cell types are derived from neural crest precursors. However,…”
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Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells by Hei Chan, Wing, Gonsalvez, David G., Young, Heather M., Michelle Southard‐Smith, E., Cane, Kylie N., Anderson, Colin R.

“…ABSTRACT Adrenal medullary chromaffin cells and peripheral sympathetic neurons originate from a common sympathoadrenal (SA) progenitor cell. The timing and…”
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LRIG1 Regulates Ontogeny of Smooth Muscle−Derived Subsets of Interstitial Cells of Cajal in Mice by Kondo, Jumpei, Powell, Anne E, Wang, Yang, Musser, Melissa A, Southard-Smith, E. Michelle, Franklin, Jeffrey L, Coffey, Robert J

“…Background & Aims Interstitial cells of Cajal (ICC) control intestinal smooth muscle contraction to regulate gut motility. ICC within the plane of the…”
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A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry by Ikeda, Keiko, Takahashi, Masanori, Sato, Shigeru, Igarashi, Hiroyuki, Ishizuka, Toru, Yawo, Hiromu, Arata, Satoru, Southard-Smith, E Michelle, Kawakami, Kiyoshi, Onimaru, Hiroshi

“…The key role of the respiratory neural center is respiratory rhythm generation to maintain homeostasis through the control of arterial blood pCO2/pH and pO2…”
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An illustrated anatomical ontology of the developing mouse lower urogenital tract by Georgas, Kylie M, Armstrong, Jane, Keast, Janet R, Larkins, Christine E, McHugh, Kirk M, Southard-Smith, E Michelle, Cohn, Martin J, Batourina, Ekatherina, Dan, Hanbin, Schneider, Kerry, Buehler, Dennis P, Wiese, Carrie B, Brennan, Jane, Davies, Jamie A, Harding, Simon D, Baldock, Richard A, Little, Melissa H, Vezina, Chad M, Mendelsohn, Cathy

“…Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle…”
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Balancing on the crest – Evidence for disruption of the enteric ganglia via inappropriate lineage segregation and consequences for gastrointestinal function by Musser, Melissa A., Michelle Southard-Smith, E.

“…Normal enteric nervous system (ENS) development relies on numerous factors, including appropriate migration, proliferation, differentiation, and maturation of…”
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5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract by Ritter, K Elaine, Buehler, Dennis P, Asher, Stephanie B, Deal, Karen K, Zhao, Shilin, Guo, Yan, Southard-Smith, E Michelle

“…The autonomic nervous system derives from the neural crest (NC) and supplies motor innervation to the smooth muscle of visceral organs, including the lower…”
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Hybridization Chain Reaction for mRNA Localization in Single Cells from Mouse and Human Cryosections by May-Zhang, Aaron A, Benthal, Joseph T, Southard-Smith, E Michelle

“…In situ hybridization has been a robust method for detection of mRNA expression in whole-mount samples or tissue sections for more than 50 years. Recent…”
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Isolation and live imaging of enteric progenitors based on Sox10-Histone2BVenus transgene expression by Corpening, Jennifer C., Deal, Karen K., Cantrell, V. Ashley, Skelton, Stephanie B., Buehler, Dennis P., Southard-Smith, E. Michelle

“…To facilitate dynamic imaging of neural crest (NC) lineages and discrimination of individual cells in the enteric nervous system (ENS) where close…”
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In the Enteric Nervous System, It’s All About Connections by Avila, Justin A., Southard-Smith, E. Michelle

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A Uchl1-Histone2BmCherry:GFP-gpi BAC transgene for imaging neuronal progenitors by Wiese, Carrie B., Fleming, Nicole, Buehler, Dennis P., Southard-Smith, E. Michelle

“…Uchl1 encodes the protein gene product 9.5 antigen (PGP9.5) that is a widely used to identify migrating neural progenitors in the PNS, mature neurons of the…”
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Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract by Ritter, K Elaine, Southard-Smith, E Michelle

“…Sensory afferent signaling is required for normal function of the lower urinary tract (LUT). Despite the wide prevalence of bladder dysfunction and pelvic pain…”
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