Search Results - "Smith, Mandy D."

CRISPR based editing of SIV proviral DNA in ART treated non-human primates by Mancuso, Pietro, Chen, Chen, Kaminski, Rafal, Gordon, Jennifer, Liao, Shuren, Robinson, Jake A., Smith, Mandy D., Liu, Hong, Sariyer, Ilker K., Sariyer, Rahsan, Peterson, Tiffany A., Donadoni, Martina, Williams, Jaclyn B., Siddiqui, Summer, Bunnell, Bruce A., Ling, Binhua, MacLean, Andrew G., Burdo, Tricia H., Khalili, Kamel

“…Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a…”
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Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques by Podgorski, Rachel M, Robinson, Jake A, Smith, Mandy D, Mallick, Suvadip, Zhao, Huaqing, Veazey, Ronald S, Kolson, Dennis L, Bar, Katharine J, Burdo, Tricia H

“…A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV…”
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Increased Peripheral Inflammation Is Associated With Structural Brain Changes and Reduced Blood Flow in People With Virologically Controlled HIV by Burdo, Tricia H, Robinson, Jake A, Cooley, Sarah, Smith, Mandy D, Flynn, Jacqueline, Petersen, Kalen J, Nelson, Brittany, Westerhaus, Elizabeth, Wisch, Julie, Ances, Beau M

“…Abstract Background While antiretroviral therapy (ART) has improved outcomes for people with HIV (PWH), brain dysfunction is still evident. Immune activation…”
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Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates by Burdo, Tricia H., Chen, Chen, Kaminski, Rafal, Sariyer, Ilker K., Mancuso, Pietro, Donadoni, Martina, Smith, Mandy D., Sariyer, Rahsan, Caocci, Maurizio, Liao, Shuren, Liu, Hong, Huo, Wenwen, Zhao, Huaqing, Misamore, John, Lewis, Mark G., Simonyan, Vahan, Thompson, Elaine E., Xu, Ethan Y., Cradick, Thomas J., Gordon, Jennifer, Khalili, Kamel

“…In this study, we demonstrate the safety and utility of CRISPR-Cas9 gene editing technology for in vivo editing of proviral DNA in ART-treated, virally…”
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Identification of potential regulatory domains within the MreC and MreD components of the cell elongation machinery by Rohs, Patricia D A, Qiu, Jeanna M, Torres, Grasiela, Smith, Mandy D, Fivenson, Elayne M, Bernhardt, Thomas G

“…The bacterial peptidoglycan (PG) cell wall maintains cell shape and prevents osmotic lysis. During growth of rod-shaped cells, PG is incorporated along the…”
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SIV-Mediated Synaptic Dysfunction Is Associated with an Increase in Synapsin Site 1 Phosphorylation and Impaired PP2A Activity by Shekarabi, Masoud, Robinson, Jake A, Smith, Mandy D, Burdo, Tricia H

“…Although the reduction of viral loads in people with HIV undergoing combination antiretroviral therapy has mitigated AIDS-related symptoms, the prevalence of…”
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Correction: Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates by Burdo, Tricia H., Chen, Chen, Kaminski, Rafal, Sariyer, Ilker K., Mancuso, Pietro, Donadoni, Martina, Smith, Mandy D., Sariyer, Rahsan, Caocci, Maurizio, Liao, Shuren, Liu, Hong, Huo, Wenwen, Zhao, Huaqing, Misamore, John, Lewis, Mark G., Simonyan, Vahan, Thompson, Elaine E., Xu, Ethan Y., Cradick, Thomas J., Gordon, Jennifer, Khalili, Kamel

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Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection by Robinson, Jake A., Guenthner, Guy, Warfield, Rebecca, Kublin, Jessica R., Smith, Mandy D., Shekarabi, Masoud, Miller, Andrew D., Burdo, Tricia H.

“…HIV-associated sensory neuropathy is a common neurologic comorbidity of HIV infection and prevails in the post–antiretroviral therapy (ART) era. HIV infection…”
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Factors Associated With Systemic Immune Activation Indices in a Global Primary Cardiovascular Disease Prevention Cohort of People With Human Immunodeficiency Virus on Antiretroviral Therapy by Looby, Sara E, Kantor, Amy, Burdo, Tricia H, Currier, Judith S, Fichtenbaum, Carl J, Overton, Edgar T, Aberg, Judith A, Malvestutto, Carlos D, Bloomfield, Gerald S, Erlandson, Kristine M, Cespedes, Michelle, Kallas, Esper G, Masiá, Mar, Thornton, Alice C, Smith, Mandy D, Flynn, Jacqueline M, Kileel, Emma M, Fulda, Evelynne, Fitch, Kathleen V, Lu, Michael T, Douglas, Pamela S, Grinspoon, Steven K, Ribaudo, Heather J, Zanni, Markella V

“…Among antiretroviral therapy (ART)-treated people with human immunodeficiency virus (PWH), persistent systemic immune activation contributes to atherogenesis…”
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Comparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals by Boerwinkle, Anna H., Strain, Jeremy F., Burdo, Tricia, Doyle, John, Christensen, Jon, Su, Yi, Wisch, Julie K., Cooley, Sarah A., Vaida, Florin, Smith, Mandy D., Jafri, Hussain, Paul, Robert H., Benzinger, Tammie L.S., Ances, Beau M.

“…OBJECTIVE:Despite combined antiretroviral therapy, neuroinflammation may persist in persons living with HIV (PLWH) and contribute to cognitive impairment in…”
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An extension of the 'two-baskets' theory to Native Americans by Trafimow, David, Smith, Mandy D.

“…A theory that private and collective self‐cognitions are stored in separate locations in memory (Trafimow, Triandis, & Goto, 1991; Trafimow, Silverman, Fan, &…”
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Couples and condoms: A dyadic approach to condom decision -making in Latino and Anglo dating couples by Smith, Mandy D

“…When studying HIV preventative behavior such as condom use, by far the most common perspective is to study the individual. The study utilized a matched-pairs…”
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