Search Results - "Smith, M. Timothy"

Targeting ADAM10 in Cancer and Autoimmunity by Smith, Jr, Timothy M, Tharakan, Anuj, Martin, Rebecca K

“…Generating inhibitors for A Disintegrin And Metalloproteinase 10 (ADAM10), a zinc-dependent protease, was heavily invested in by the pharmaceutical industry…”
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Microstructure Segmentation With Deep Learning Encoders Pre-Trained on a Large Microscopy Dataset by Stuckner, Joshua, Harder, Bryan, Smith, Timothy M.

“…This study examined the improvement of microscopy segmentation intersection over union accuracy by transfer learning from a large dataset of microscopy images…”
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Thermally Primed Zostera muelleri Seeds Exhibit Higher Germination Rates Than Those From Ambient Conditions by Moir, Tom, Huggett, Megan J., Smith, Timothy M., Gaston, Troy F.

“…ABSTRACT Seagrasses provide critical ecosystem services such as carbon sequestration, sediment stabilisation and nursery habitat for juvenile fish. Zostera…”
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Indirect grazing‐induced mechanisms contribute to the resilience of Mediterranean seagrass meadows to sea urchin herbivory by Buñuel, Xavier, Alcoverro, Teresa, Boada, Jordi, Zinkunegi, Leire, Smith, Timothy M., Barrera, Anaïs, Casas, Marc, Farina, Simone, Pérez, Marta, Romero, Javier, Arthur, Rohan, Pagès, Jordi F.

“…Plant–herbivore interactions are often regulated by a series of direct and indirect buffer mechanisms (compensatory or defensive plant responses, population…”
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A report card approach to describe temporal and spatial trends in parameters for coastal seagrass habitats by Carter, Alex B., Coles, Rob, Jarvis, Jessie C., Bryant, Catherine V., Smith, Timothy M., Rasheed, Michael A.

“…Report cards that are designed to monitor environmental trends have the potential to provide a powerful communication tool because they are easy to understand…”
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Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer by Rashid, Narmeen S., Boyd, David C., Olex, Amy L., Grible, Jacqueline M., Duong, Alex K., Alzubi, Mohammad A., Altman, Julia E., Leftwich, Tess J., Valentine, Aaron D., Hairr, Nicole S., Zboril, Emily K., Smith, Timothy M., Pfefferle, Adam D., Dozmorov, Mikhail G., Harrell, J. Chuck

“…The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal…”
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Unique water scarcity footprints and water risks in US meat and ethanol supply chains identified via subnational commodity flows by Brauman, Kate A, Goodkind, Andrew L, Kim, Taegon, Pelton, Rylie E O, Schmitt, Jennifer, Smith, Timothy M

“…Within the US, supply chains aggregate agricultural production and associated environmental impacts in specific downstream products and companies. This is…”
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Energy-Composition Relations in Ni3(Al1−xXx) Phases by Zarkevich, Nikolai A., Smith, Timothy M., Lawson, John W.

“…The secondary phase, such as Ni3Al-based L12 γ′, is crucially important for the precipitation strengthening of superalloys. Composition–structure–property…”
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Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy by Aqbi, Hussein F, Tyutyunyk-Massey, Liliya, Keim, Rebecca C, Butler, Savannah E, Thekkudan, Theresa, Joshi, Supriya, Smith, Timothy M, Bandyopadhyay, Dipankar, Idowu, Michael O, Bear, Harry D, Payne, Kyle K, Gewirtz, David A, Manjili, Masoud H

“…Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same…”
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Quantifying nitrogen loss hotspots and mitigation potential for individual fields in the US Corn Belt with a metamodeling approach by Kim, Taegon, Jin, Zhenong, Smith, Timothy M, Liu, Licheng, Yang, Yufeng, Yang, Yi, Peng, Bin, Phillips, Kathryn, Guan, Kaiyu, Hunter, Luyi C, Zhou, Wang

“…Abstract The high productivity in the US Corn Belt is largely enabled by the consumption of millions of tons of manufactured fertilizer. Excessive application…”
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The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer by Luker, Andrea J, Graham, Laura J, Smith, Jr, Timothy M, Camarena, Carmen, Zellner, Matt P, Gilmer, Jamie-Jean S, Damle, Sheela R, Conrad, Daniel H, Bear, Harry D, Martin, Rebecca K

“…Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses…”
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Highly Disturbed Populations of Seagrass Show Increased Resilience but Lower Genotypic Diversity by Connolly, Rod M, Smith, Timothy M, Maxwell, Paul S, Olds, Andrew D, Macreadie, Peter I, Sherman, Craig D H

“…The response of seagrass systems to a severe disturbance provides an opportunity to quantify the degree of resilience in different meadows, and subsequently to…”
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Utilizing local phase transformation strengthening for nickel-base superalloys by Smith, Timothy M., Zarkevich, Nikolai A., Egan, Ashton J., Stuckner, Joshua, Gabb, Timothy P., Lawson, John W., Mills, Michael J.

“…Almost 75 years of research has been devoted to producing superalloys capable of higher operating temperatures in jet turbine engines, and there is an ongoing…”
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On the origin of extraordinary cyclic strengthening of the austenitic stainless steel Sanicro 25 during fatigue at 700 °C by Heczko, Milan, Esser, Bryan D., Smith, Timothy M., Beran, Přemysl, Mazánová, Veronika, Kruml, Tomáš, Polák, Jaroslav, Mills, Michael J.

“…The origin of the extraordinary strengthening of the highly alloyed austenitic stainless steel Sanicro 25 during cyclic loading at 700 °C was investigated by…”
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Compositional Glass: A State with Inherent Chemical Disorder, Exemplified by Ti-rich Ni3(Al,Ti)1 D024 Phase by Zarkevich, Nikolai, Smith, Timothy, Baum, Eli, Lawson, John

“…A compositional glass is a state with an unavoidable disorder in chemical compositions on each site, characterized by frustration and freezing of the…”
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Mucosal Melanomas: Site-Specific Information, Comparisons With Cutaneous Tumors, & Differential Diagnosis by Dominiak, Nicole R., M.D, Wick, Mark R., M.D, Smith, M. Timothy, M.D

“…Abstract Melanoma of the skin is the fifth leading new cancer diagnosis, having accounted for almost 77,000 cases and more than 9000 deaths in the U.S. in…”
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Blue Nevus & “Malignant Blue Nevus:” A Concise Review by Sugianto, Jessica Zarah, M.D, Ralston, Jonathan Scott, M.D, Metcalf, John S., M.D, McFaddin, Courtney L., M.D, Smith, M. Timothy, M.D

“…Abstract Blue nevi are a heterogeneous group of lesions that can display a variety of different clinicopathological characteristics. Although attempts are made…”
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A Review on the Partitioning of Solutes Along Dislocations and Stacking Faults in Superalloys by Kontis, Paraskevas, Smith, Timothy M.

“…Chemical and microstructural alterations at near-atomic scale can influence the high temperature mechanical performance of superalloys. These alterations are…”
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Seed germination in a southern Australian temperate seagrass by Cumming, Erin, Jarvis, Jessie C, Sherman, Craig D H, York, Paul H, Smith, Timothy M

“…In a series of experiments, seeds from a temperate seagrass species, collected in Port Phillip Bay, Victoria, Australia were exposed to a range of salinities…”
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Comparative life cycle assessment of fossil and bio-based polyethylene terephthalate (PET) bottles by Chen, Luyi, Pelton, Rylie E.O., Smith, Timothy M.

“…Both biofuels and bioplastics are often regarded as sustainable solutions to current environmental problems such as climate change, fossil depletion and…”
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