Search Results - "Smith, Lee B"

The regulation of spermatogenesis by androgens by Smith, Lee B., Walker, William H.

“…•Testosterone maintains BTB, meiosis, Sertoli–spermatid adhesion and spermiation.•Testosterone acts via classical and non-classical pathways.•Testosterone…”
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Androgen receptor roles in spermatogenesis and infertility by O'Hara, Laura, Ph.D, Smith, Lee B., Ph.D

“…Androgens such as testosterone are steroid hormones essential for normal male reproductive development and function. Mutations of androgen receptors (AR) are…”
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Sertoli Cell Number Defines and Predicts Germ and Leydig Cell Population Sizes in the Adult Mouse Testis by Rebourcet, Diane, Darbey, Annalucia, Monteiro, Ana, Soffientini, Ugo, Tsai, Yi Ting, Handel, Ian, Pitetti, Jean-Luc, Nef, Serge, Smith, Lee B, O’Shaughnessy, Peter J

“…Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of…”
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Bi-allelic Recessive Loss-of-Function Variants in FANCM Cause Non-obstructive Azoospermia by Kasak, Laura, Punab, Margus, Nagirnaja, Liina, Grigorova, Marina, Minajeva, Ave, Lopes, Alexandra M., Punab, Anna Maria, Aston, Kenneth I., Carvalho, Filipa, Laasik, Eve, Smith, Lee B., Conrad, Donald F., Laan, Maris

“…Infertility affects around 7% of men worldwide. Idiopathic non-obstructive azoospermia (NOA) is defined as the absence of spermatozoa in the ejaculate due to…”
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New Insights into Testosterone Biosynthesis: Novel Observations from HSD17B3 Deficient Mice by Lawrence, Ben M, O'Donnell, Liza, Smith, Lee B, Rebourcet, Diane

“…Androgens such as testosterone and dihydrotestosterone (DHT) are essential for male sexual development, masculinisation, and fertility. Testosterone is…”
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Deciphering Cell Lineage Specification during Male Sex Determination with Single-Cell RNA Sequencing by Stévant, Isabelle, Neirijnck, Yasmine, Borel, Christelle, Escoffier, Jessica, Smith, Lee B., Antonarakis, Stylianos E., Dermitzakis, Emmanouil T., Nef, Serge

“…The gonad is a unique biological system for studying cell-fate decisions. However, major questions remain regarding the identity of somatic progenitor cells…”
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Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism by Welsh, Michelle, Saunders, Philippa T K, Fisken, Mark, Scott, Hayley M, Hutchison, Gary R, Smith, Lee B, Sharpe, Richard M

“…Becoming a phenotypic male is ultimately determined by androgen-induced masculinization. Disorders of fetal masculinization, resulting in hypospadias or…”
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Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production by Rebourcet, Diane, Mackay, Rosa, Darbey, Annalucia, Curley, Michael K., Jørgensen, Anne, Frederiksen, Hanne, Mitchell, Rod T., O’Shaughnessy, Peter J., Nef, Serge, Smith, Lee B.

“…Male development, fertility, and lifelong health are all androgen‐dependent. Approximately 95% of circulating testosterone is synthesized by the testis and the…”
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Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes by Hall, Emma A, Keighren, Margaret, Ford, Matthew J, Davey, Tracey, Jarman, Andrew P, Smith, Lee B, Jackson, Ian J, Mill, Pleasantine

“…Defects in cilium and centrosome function result in a spectrum of clinically-related disorders, known as ciliopathies. However, the complex molecular…”
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Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells by Kilcoyne, Karen R, Smith, Lee B, Atanassova, Nina, Macpherson, Sheila, McKinnell, Chris, van den Driesche, Sander, Jobling, Matthew S, Chambers, Thomas J G, De Gendt, Karel, Verhoeven, Guido, O'Hara, Laura, Platts, Sophie, Renato de Franca, Luiz, Lara, Nathália L M, Anderson, Richard A, Sharpe, Richard M

“…Fetal growth plays a role in programming of adult cardiometabolic disorders, which in men, are associated with lowered testosterone levels. Fetal growth and…”
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Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late‐onset Leydig cell apoptosis in both mice and men by O'Hara, Laura, McInnes, Kerry, Simitsidellis, Ioannis, Morgan, Stephanie, Atanassova, Nina, Slowikowska‐Hilczer, Jolanta, Kula, Krzysztof, Szarras‐Czapnik, Maria, Milne, Laura, Mitchell, Rod T., Smith, Lee B.

“…Leydig cell number and function decline as men age, and low testosterone is associated with all “Western” cardio‐metabolic disorders. However, whether…”
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A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function by Gannon, Anne-Louise, Darbey, Annalucia L, Chensee, Grace, Lawrence, Ben M, O'Donnell, Liza, Kelso, Joanna, Reed, Natalie, Parameswaran, Shanmathi, Smith, Sarah, Smith, Lee B, Rebourcet, Diane

“…Glucocorticoids are steroids involved in key physiological processes such as development, metabolism, inflammatory and stress responses and are mostly used…”
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Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility by Zimmermann, Céline, Romero, Yannick, Warnefors, Maria, Bilican, Adem, Borel, Christelle, Smith, Lee B, Kotaja, Noora, Kaessmann, Henrik, Nef, Serge

“…Small non-coding RNAs act as critical regulators of gene expression and are essential for male germ cell development and spermatogenesis. Previously, we showed…”
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Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis by Rebourcet, Diane, O'Shaughnessy, Peter J, Pitetti, Jean-Luc, Monteiro, Ana, O'Hara, Laura, Milne, Laura, Tsai, Yi Ting, Cruickshanks, Lyndsey, Riethmacher, Dieter, Guillou, Florian, Mitchell, Rod T, van't Hof, Rob, Freeman, Tom C, Nef, Serge, Smith, Lee B

“…Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their…”
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Sertoli cell-enriched proteins in mouse and human testicular interstitial fluid by O'Donnell, Liza, Dagley, Laura F, Curley, Michael, Darbey, Annalucia, O'Shaughnessy, Peter J, Diemer, Thorsten, Pilatz, Adrian, Fietz, Daniela, Stanton, Peter G, Smith, Lee B, Rebourcet, Diane

“…Sertoli cells support the development of sperm and the function of various somatic cells in the interstitium between the tubules. Sertoli cells regulate the…”
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Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging by Cobice, Diego F, Livingstone, Dawn E. W, Mackay, C. Logan, Goodwin, Richard J. A, Smith, Lee B, Walker, Brian R, Andrew, Ruth

“…Androgens are essential for male development and reproductive function. They are transported to their site of action as blood-borne endocrine hormones but can…”
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Anogenital Distance Plasticity in Adulthood: Implications for Its Use as a Biomarker of Fetal Androgen Action by Mitchell, Rod T, Mungall, Will, McKinnell, Chris, Sharpe, Richard M, Cruickshanks, Lyndsey, Milne, Laura, Smith, Lee B

“…Androgen action during the fetal masculinization programming window (MPW) determines the maximum potential for growth of androgen-dependent organs (eg, seminal…”
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Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells by Neirijnck, Yasmine, Calvel, Pierre, Kilcoyne, Karen R., Kühne, Françoise, Stévant, Isabelle, Griffeth, Richard J., Pitetti, Jean-Lüc, Andric, Silvana A., Hu, Meng-Chun, Pralong, François, Smith, Lee B., Nef, Serge

“…ABSTRACT The insulin family of growth factors (insulin, IGF1, and IGF2) are critical in sex determination, adrenal differentiation, and testicular function…”
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Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis by MCINNES, Kerry J, SMITH, Lee B, HUNGER, Nicole I, SAUNDERS, Philippa T. K, ANDREW, Ruth, WALKER, Brian R

“…Testosterone deficiency is epidemic in obese ageing males with type 2 diabetes, but the direction of causality remains unclear. Testosterone-deficient males…”
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Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics by Patel, Saloni H., O’Hara, Laura, Atanassova, Nina, Smith, Sarah E., Curley, Michael K., Rebourcet, Diane, Darbey, Annalucia L., Gannon, Anne-Louise, Sharpe, Richard M., Smith, Lee B.

“…The tamoxifen-inducible Cre system is a popular transgenic method for controlling the induction of recombination by Cre at a specific time and in a specific…”
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