Search Results - "Smith, Lawrence C."

Oocyte Selection for In Vitro Embryo Production in Bovine Species: Noninvasive Approaches for New Challenges of Oocyte Competence by Aguila, Luis, Treulen, Favian, Therrien, Jacinthe, Felmer, Ricardo, Valdivia, Martha, Smith, Lawrence C

“…The efficiency of producing embryos using in vitro technologies in livestock species rarely exceeds the 30-40% threshold, indicating that the proportion of…”
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BH4 peptide derived from Bcl-xL and Bax-inhibitor peptide suppresses apoptotic mitochondrial changes in heat stressed bovine oocytes by Soto, Paolete, Smith, Lawrence C.

“…Mitochondria play an important role in the integration and transmission of cell death signals mediated by the Bcl‐2 family proteins. Experiments were conducted…”
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Molecular control of mitochondrial function in preimplantation mouse embryos by Thundathil, Jacob, Filion, France, Smith, Lawrence C.

“…Mitochondria play a key role in a number of physiological events during all stages of life, including the very first stages following fertilization. It is,…”
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Epigenetic consequences of artificial reproductive technologies to the bovine imprinted genes SNRPN, H19/IGF2, and IGF2R by Smith, Lawrence C, Therrien, Jacinthe, Filion, France, Bressan, Fabiana, Meirelles, Flávio V

“…Animal breeders have made widespread use of assisted reproductive technologies to accelerate genetic improvement programs aimed at obtaining more, better and…”
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Embryo Mitochondrial DNA Depletion Is Reversed During Early Embryogenesis in Cattle by Chiaratti, Marcos R, Bressan, Fabiana F, Ferreira, Christina R, Caetano, Alexandre R, Smith, Lawrence C, Vercesi, Aníbal E, Meirelles, Flávio V

“…The extensive replication of mitochondria during oogenesis and the wide variability in mitochondrial DNA (mtDNA) copy numbers present in fully grown oocytes…”
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Dysregulated Gene Expression of Imprinted and X-Linked Genes: A Link to Poor Development of Bovine Haploid Androgenetic Embryos by Aguila, Luis, Suzuki, Joao, Hill, Amanda B T, García, Mónica, de Mattos, Karine, Therrien, Jacinthe, Smith, Lawrence C

“…Mammalian uniparental embryos are efficient models for genome imprinting research and allow studies on the contribution of the paternal and maternal genomes to…”
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In Vitro Induction of Pluripotency from Equine Fibroblasts in 20% or 5% Oxygen by Bressan, Fabiana F., Garcia, Joaquim M., Meirelles, Flavio V., Dória, Renata G. S., Grizendi, Bianca M., Fantinato Neto, Paulo, Pieri, Naira C. G., de Castro, Raquel V. G., Smith, Lawrence C.

“…The cellular reprogramming into pluripotency is influenced by external and internal cellular factors, such as in vitro culture conditions (e.g., environmental…”
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Equine Induced Pluripotent Stem Cells have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells by Bavin, Emma P, Smith, Olivia, Baird, Arabella E G, Smith, Lawrence C, Guest, Deborah J

“…Tendon injuries occur commonly in horses and their repair through scar tissue formation predisposes horses to a high rate of re-injury. Pluripotent stem cells…”
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Somatic cell nuclear transfer alters peri-implantation trophoblast differentiation in bovine embryos by Arnold, Daniel R, Bordignon, Vilceu, Lefebvre, Réjean, Murphy, Bruce D, Smith, Lawrence C

“…Abnormal placental development limits success in ruminant pregnancies derived from somatic cell nuclear transfer (SCNT), due to reduction in placentome number…”
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The Influence of Nuclear Content on Developmental Competence of Gaur × Cattle Hybrid In Vitro Fertilized and Somatic Cell Nuclear Transfer Embryos by MASTROMONACO, Gabriela F, FAVETTA, Laura A, SMITH, Lawrence C, FILION, France, KING, W. Allan

“…In nondomestic and endangered species, the use of domestic animal oocytes as recipients for exotic donor nuclei causes the normal pattern of cytoplasmic…”
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Characterization of mitochondrial replication and transcription control during rat early development in vivo and in vitro by Kameyama, Yuichi, Filion, France, Yoo, Jae Gyu, Smith, Lawrence C

“…In vitro culture (IVC), used in assisted reproductive technologies, is a major environmental stress on the embryo. To evaluate the effect of IVC on…”
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Trophoblast stem cell marker gene expression in inner cell mass-derived cells from parthenogenetic equine embryos by Desmarais, Joëlle A, Demers, Simon-Pierre, Suzuki, Joao, Laflamme, Simon, Vincent, Patrick, Laverty, Sheila, Smith, Lawrence C

“…Although putative horse embryonic stem (ES)-like cell lines have been obtained recently from in vivo-derived embryos, it is currently not known whether it is…”
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Expression of steroidogenic proteins in bovine placenta during the first half of gestation by Verduzco, Adriana, Fecteau, Gilles, Lefebvre, Réjean, Smith, Lawrence C, Murphy, Bruce D

“…The aim of the present study was to determine the occurrence and localisation of the principal steroidogenic proteins in bovine placenta from Day 50 to Day 120…”
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Replacing sperm with genotyped haploid androgenetic blastomeres to generate cattle with predetermined paternal genomes by Aguila, Luis, Sampaio, Rafael V, Therrien, Jacinthe, Nociti, Ricardo P, Labrecque, Remi, Tremblay, Amelie, Marras, Gabrielle, Blondin, Patrick, Smith, Lawrence C

“…Although meiosis plays an essential role for the survival of species in natural selection, the genetic diversity resulting from sexual reproduction impedes…”
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Haploid androgenetic development of bovine embryos reveals imbalanced WNT signaling and impaired cell fate differentiation by Aguila, Luis, Nociti, Ricardo P., Sampaio, Rafael V., Therrien, Jacinthe, Meirelles, Flavio V., Felmer, Ricardo N., Smith, Lawrence C.

“…Haploid embryos have contributed significantly to our understanding of the role of parental genomes in development and can be applied to important…”
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Role of the mitochondrial genome in preimplantation development and assisted reproductive technologies by Smith, Lawrence C, Thundathil, Jacob, Filion, France

“…Our fascination for mitochondria relates to their origin as symbiotic, semi-independent organisms on which we, as eukaryotic beings, rely nearly exclusively to…”
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Transgene Expression of Green Fluorescent Protein and Germ Line Transmission in Cloned Calves Derived from In Vitro-Transfected Somatic Cells by BORDIGNON, Vilceu, KEYSTON, Rebecca, LAZARIS, Anthoula, BILODEAU, Annie S, PONTES, José H. F, ARNOLD, Daniel, FECTEAU, Gilles, KEEFER, Carol, SMITH, Lawrence C

“…In vitro transfection of cultured cells combined with nuclear transfer currently is the most effective procedure to produce transgenic livestock. In the…”
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Complete replacement of the mitochondrial genotype in a Bos indicus calf reconstructed by nuclear transfer to a Bos taurus oocyte by Meirelles, F V, Bordignon, V, Watanabe, Y, Watanabe, M, Dayan, A, Lôbo, R B, Garcia, J M, Smith, L C

“…Due to the exclusively maternal inheritance of mitochondria, mitochondrial genotypes can be coupled to a particular nuclear genotype by continuous mating of…”
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Asymmetrical allocation of mitochondrial DNA to blastomeres during the first two cleavages in mouse embryos by Kameyama, Yuichi, Ohnishi, Hidehisa, Shimoi, Gaku, Hashizume, Ryoichi, Ito, Masao, Smith, Lawrence C

“…A recent report showed higher oxygen consumption, adenosine triphosphate (ATP) production and mitochondrial localisation in trophectoderm cells than in the…”
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Embryo Mitochondrial DNA Depletion Is Reversed During Early Embryogenesis in Cattle1 by Chiaratti, Marcos R, Bressan, Fabiana F, Ferreira, Christina R, Caetano, Alexandre R, Smith, Lawrence C, Vercesi, Aníbal E, Meirelles, Flávio V

“…The extensive replication of mitochondria during oogenesis and the wide variability in mitochondrial DNA (mtDNA) copy numbers present in fully grown oocytes…”
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