Search Results - "Smith, Laura J"

A rapid, neural measure of implicit recognition memory using fast periodic visual stimulation by Stothart, George, Smith, Laura J., Milton, Alexander

“…Fast periodic visual stimulation (FPVS) has recently emerged as a powerful new tool in cognitive neuroscience. Capable of measuring a range of cognitive…”
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Cognition in vestibular disorders: state of the field, challenges, and priorities for the future by Smith, Laura J, Wilkinson, David, Bodani, Mayur, Surenthiran, S S

“…Vestibular disorders are prevalent and debilitating conditions of the inner ear and brain which affect balance, coordination, and the integration of…”
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Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High‐Content Drug Screening by Tam, Roger Y., Yockell‐Lelièvre, Julien, Smith, Laura J., Julian, Lisa M., Baker, Alexander E. G., Choey, Chandarong, Hasim, Mohamed S., Dimitroulakos, Jim, Stanford, William L., Shoichet, Molly S.

“…Cell behavior is highly dependent upon microenvironment. Thus, to identify drugs targeting metastatic cancer, screens need to be performed in tissue mimetic…”
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Impact and experiences of vestibular disorders and psychological distress: Qualitative findings from patients, family members and healthcare professionals by Smith, Laura J., Pyke, Wesley, Fowler, Rosanna, Matthes, Britta, Goederen, Emma, Surenthiran, Shanmuga

“…Introduction People with vestibular disorders frequently experience reduced quality of life and challenges with activities of daily living. Anxiety, depression…”
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Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches by Green, Jeffrey, Stapleton, Melanie R, Smith, Laura J, Artymiuk, Peter J, Kahramanoglou, Christina, Hunt, Debbie M, Buxton, Roger S

“…Highlights • E. coli cyclic-AMP receptor protein (CRP) is a paradigm of gene regulation. • Comparison of CRPs reveals differences in their affinity of cAMP. •…”
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Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing by Smith, Laura J., Wright, Jason, Clark, Gabriella, Ul-Hasan, Taihra, Jin, Xiangyang, Fong, Abigail, Chandra, Manasa, St Martin, Thia, Rubin, Hillard, Knowlton, David, Ellsworth, Jeff L., Fong, Yuman, Wong, Kamehameha K., Chatterjee, Saswati

“…The precise correction of genetic mutations at the nucleotide level is an attractive permanent therapeutic strategy for human disease. However, despite…”
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Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes by Rizwan, Muhammad, Fokina, Ana, Kivijärvi, Tove, Ogawa, Mina, Kufleitner, Markus, Laselva, Onofrio, Smith, Laura J., Bear, Christine E., Ogawa, Shinichiro, Keller, Gordon, Shoichet, Molly S.

“…Cholangiocytes form an intricate network of bile ducts to enable proper liver function; yet, recapitulating human stem cell differentiation to cholangiocytes…”
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Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates by Ellsworth, Jeff L, Gingras, Jacinthe, Smith, Laura J, Rubin, Hillard, Seabrook, Tania A, Patel, Kruti, Zapata, Nicole, Olivieri, Kevin, O'Callaghan, Michael, Chlipala, Elizabeth, Morales, Pablo, Seymour, Albert

“…The biodistribution of AAVHSC7, AAVHSC15, and AAVHSC17 following systemic delivery was assessed in cynomolgus macaques (Macaca fascicularis). Animals received…”
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Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease by Smith, Laura J, Lee, Chiao-Yin, Menozzi, Elisa, Schapira, Anthony H V

“…Variants in the and genes are the most common genetic risk factors associated with Parkinson disease (PD). Both genes are associated with lysosomal and…”
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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis by Kudhair, Bassam K., Hounslow, Andrea M., Rolfe, Matthew D., Crack, Jason C., Hunt, Debbie M., Buxton, Roger S., Smith, Laura J., Le Brun, Nick E., Williamson, Michael P., Green, Jeffrey

“…Mycobacterium tuberculosis causes pulmonary tuberculosis (TB) and claims ~1.8 million human lives per annum. Host nitric oxide (NO) is important in controlling…”
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Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster by Smith, Laura J, Stapleton, Melanie R, Fullstone, Gavin J M, Crack, Jason C, Thomson, Andrew J, Le Brun, Nick E, Hunt, Debbie M, Harvey, Evelyn, Adinolfi, Salvatore, Buxton, Roger S, Green, Jeffrey

“…Mycobacterium tuberculosis is a major pathogen that has the ability to establish, and emerge from, a persistent state. Wbl family proteins are associated with…”
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Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma by Smith, Laura J., Skirzynska, Arianna, Chin, Allysia A., Arnold, Amy E., Kushida, Michelle, Dirks, Peter B., Shoichet, Molly S.

“…Glioblastoma stem cells (GSCs) play an important role in the invasive nature of glioblastoma (GBM); yet, the mechanisms driving this behavior are poorly…”
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Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1 by Smith, Laura J, Stapleton, Melanie R, Buxton, Roger S, Green, Jeffrey

“…Members of the WhiB-like (Wbl) protein family possess iron-sulfur clusters and are implicated in the regulation of developmental processes in Actinomycetes…”
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Transcriptional regulation of bacterial virulence gene expression by molecular oxygen and nitric oxide by Green, Jeffrey, Rolfe, Matthew D, Smith, Laura J

“…Molecular oxygen (O 2 ) and nitric oxide (NO) are diatomic gases that play major roles in infection. The host innate immune system generates reactive oxygen…”
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Engineering Cellular Microenvironments with Photo- and Enzymatically Responsive Hydrogels: Toward Biomimetic 3D Cell Culture Models by Tam, Roger Y, Smith, Laura J, Shoichet, Molly S

“…Conventional cell culture techniques using 2D polystyrene or glass have provided great insight into key biochemical mechanisms responsible for cellular events…”
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Tissue-Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition by Pietrobon, Adam, Yockell-Lelièvre, Julien, Melong, Nicole, Smith, Laura J, Delaney, Sean P, Azzam, Nadine, Xue, Chang, Merwin, Nishanth, Lian, Eric, Camacho-Magallanes, Alberto, Doré, Carole, Musso, Gabriel, Julian, Lisa M, Kristof, Arnold S, Tam, Roger Y, Berman, Jason N, Shoichet, Molly S, Stanford, William L

“…Lymphangioleiomyomatosis (LAM) is a rare disease involving cystic lung destruction by invasive LAM cells. These cells harbor loss-of-function mutations in…”
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Breast Injuries in Female Collegiate Basketball, Soccer, Softball and Volleyball Athletes: Prevalence, Type and Impact on Sports Participation by Smith, Laura J, Eichelberger, Tamara D, Kane, Edward J

“…In 2015-2016, over 214,000 female athletes competed at the collegiate level in the United States (U.S.). The National Collegiate Athletic Association (NCAA)…”
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Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS by Smith, Laura J., Schulman, Lindsay A., Smith, Samantha, Van Lieshout, Laura, Barnes, Carmen M., Behmoiras, Liana, Scarpitti, Meghan, Kivaa, Monicah, Duong, Khanh L., Benard, Ludo O., Ellsworth, Jeff L., Avila, Nancy, Faulkner, Deiby, Hayes, April, Lotterhand, Jason, Rivas, Jose Israel, Sengooba, Arnold V., Tzianabos, Alec, Seymour, Albert B., Francone, Omar L.

“…Adeno-associated viruses derived from human hematopoietic stem cells (AAVHSCs) are naturally occurring AAVs. Fifteen AAVHSCs have demonstrated broad…”
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Priming with biocides: A pathway to antibiotic resistance? by Adkin, Pat, Hitchcock, Andrew, Smith, Laura J., Walsh, Susannah E.

“…Aims To investigate the priming effects of sub‐inhibitory concentrations of biocides on antibiotic resistance in bacteria. Methods and results Escherichia…”
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A passive and objective measure of recognition memory in Alzheimer's disease using Fastball memory assessment by Stothart, George, Smith, Laura J, Milton, Alexander, Coulthard, Elizabeth

“…Earlier diagnosis of Alzheimer's disease requires biomarkers sensitive to associated structural and functional changes. While considerable progress has been…”
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