Search Results - "Smith, L Courtney"

Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD by Fallini, Claudia, Khalil, Bilal, Smith, Courtney L., Rossoll, Wilfried

“…Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disease that specifically affects the function and survival of spinal and cortical…”
Get full text

Lipofection mediated transfection fails for sea urchin coelomocytes by Barela Hudgell, Megan A, Smith, L Courtney

“…Molecular cloning, gene manipulation, gene expression, protein function, and gene regulation all depend on the introduction of nucleic acids into target cells…”
Get full text

Genomic Insights into the Immune System of the Sea Urchin by Rast, Jonathan P, Smith, L. Courtney, Loza-Coll, Mariano, Hibino, Taku, Litman, Gary W

“…Comparative analysis of the sea urchin genome has broad implications for the primitive state of deuterostome host defense and the genetic underpinnings of…”
Get full text

Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD by Khalil, Bilal, Linsenmeier, Miriam, Smith, Courtney L, Shorter, James, Rossoll, Wilfried

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are characterized by the…”
Get full text

A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor by Bernard, Daniel J., Smith, Courtney L., Brûlé, Emilie

“…Inhibins are gonadal hormones that suppress follicle-stimulating hormone (FSH) synthesis by pituitary gonadotrope cells. The structurally related activins…”
Get full text

Bald sea urchin disease shifts the surface microbiome on purple sea urchins in an aquarium by Shaw, Chloe G, Pavloudi, Christina, Barela Hudgell, Megan A, Crow, Ryley S, Saw, Jimmy H, Pyron, R Alexander, Smith, L Courtney

“…Abstract Bald sea urchin disease (BSUD) is most likely a bacterial infection that occurs in a wide range of sea urchin species and causes the loss of surface…”
Get full text

The SpTransformer Gene Family (Formerly Sp185/333 ) in the Purple Sea Urchin and the Functional Diversity of the Anti-Pathogen rSpTransformer-E1 Protein by Smith, L Courtney, Lun, Cheng Man

“…The complex innate immune system of sea urchins is underpinned by several multigene families including the family ( ; formerly ) with estimates of ~50 members,…”
Get full text

Spotting disease disrupts the microbiome of infected purple sea urchins, Strongylocentrotus purpuratus by Shaw, Chloe G, Pavloudi, Christina, Crow, Ryley S, Saw, Jimmy H, Smith, L Courtney

“…Spotting disease infects a variety of sea urchin species across many different marine locations. The disease is characterized by discrete lesions on the body…”
Get full text

Coelomocyte populations in the sea urchin, Strongylocentrotus purpuratus , undergo dynamic changes in response to immune challenge by Barela Hudgell, Megan A, Grayfer, Leon, Smith, L Courtney

“…The sea urchin, has seven described populations of distinct coelomocytes in the coelomic fluid that are defined by morphology, size, and for some types, by…”
Get full text

The extant immunoglobulin superfamily, member 1 gene results from an ancestral gene duplication in eutherian mammals by Smith, Courtney L, Harrison, Paul M, Bernard, Daniel J

“…Immunoglobulin superfamily, member 1 (IGSF1) is a transmembrane glycoprotein with high expression in the mammalian pituitary gland. Mutations in the IGSF1 gene…”
Get full text

Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination by Yakovenko, Iryna, Agronin, Jacob, Smith, L Courtney, Oren, Matan

“…The appearance of adaptive immunity in jawed vertebrates is termed the immunological 'Big Bang' because of the short evolutionary time over which it developed…”
Get full text

The complex set of internal repeats in SpTransformer protein sequences result in multiple but limited alternative alignments by Barela Hudgell, Megan A, Smith, L Courtney

“…The ( ) gene family encodes a set of proteins that function in the sea urchin immune system. The gene sequences have a series of internal repeats in a mosaic…”
Get full text

Recombinant SpTransformer proteins are functionally diverse for binding and phagocytosis by three subtypes of sea urchin phagocytes by Crow, Ryley S, Shaw, Chloe G, Grayfer, Leon, Smith, L Courtney

“…The California purple sea urchin, , relies solely on an innate immune system to combat the many pathogens in the marine environment. One aspect of their…”
Get full text

SpTransformer proteins from the purple sea urchin opsonize bacteria, augment phagocytosis, and retard bacterial growth by Chou, Hung-Yen, Lun, Cheng Man, Smith, L Courtney

“…The purple sea urchin, Strongylocentrotus purpuratus, has a complex and robust immune system that is mediated by a number of multi-gene families including the…”
Get full text

Sequence Diversity, Locus Structure, and Evolutionary History of the SpTransformer Genes in the Sea Urchin Genome by Barela Hudgell, Megan A, Smith, L Courtney

“…The generation of large immune gene families is often driven by evolutionary pressure exerted on host genomes by their pathogens, which has been described as…”
Get full text

Aggregation of sea urchin phagocytes is augmented in vitro by lipopolysaccharide by Majeske, Audrey J, Bayne, Christopher J, Smith, L Courtney

“…Development of protocols and media for culturing immune cells from marine invertebrates has not kept pace with advancements in mammalian immune cell culture,…”
Get full text

The Axial Organ and the Pharynx Are Sites of Hematopoiesis in the Sea Urchin by Golconda, Preethi, Buckley, Katherine M, Reynolds, Caroline R, Romanello, Jennifer P, Smith, L Courtney

“…The location of coelomocyte proliferation in adult sea urchins is unknown and speculations since the early 1800s have been based on microanatomy and tracer…”
Get full text

Innate immune complexity in the purple sea urchin: diversity of the sp185/333 system by Smith, L Courtney

“…The California purple sea urchin, Strongylocentrotus purpuratus, is a long-lived echinoderm with a complex and sophisticated innate immune system. There are…”
Get full text

Single sea urchin phagocytes express messages of a single sequence from the diverse Sp185/333 gene family in response to bacterial challenge by Majeske, Audrey J, Oren, Matan, Sacchi, Sandro, Smith, L Courtney

“…Immune systems in animals rely on fast and efficient responses to a wide variety of pathogens. The Sp185/333 gene family in the purple sea urchin,…”
Get full text

Multitasking Immune Sp185/333 Protein, rSpTransformer-E1, and Its Recombinant Fragments Undergo Secondary Structural Transformation upon Binding Targets by Lun, Cheng Man, Bishop, Barney M, Smith, L Courtney

“…The purple sea urchin, , expresses a diverse immune response protein family called Sp185/333. A recombinant Sp185/333 protein, previously called rSp0032, shows…”
Get full text