Search Results - "Smith, Kenneth Gc"

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection by Linterman, Michelle A, Denton, Alice E, Divekar, Devina P, Zvetkova, Ilona, Kane, Leanne, Ferreira, Cristina, Veldhoen, Marc, Clare, Simon, Dougan, Gordon, Espéli, Marion, Smith, Kenneth G C

“…The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in…”
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Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification by Lyons, Paul A, Koukoulaki, Maria, Hatton, Alexander, Doggett, Karen, Woffendin, Hayley B, Chaudhry, Afzal N, Smith, Kenneth G C

“…For expression profiling to have a practical impact in the management of immune-related disease it is essential that it can be applied to peripheral blood…”
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Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis by Carr, Edward J, Niederer, Heather A, Williams, Julie, Harper, Lorraine, Watts, Richard A, Lyons, Paul A, Smith, Kenneth G C

“…The genetic contribution to the aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is not well defined. Across different…”
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Patient stratification and genomics: flares, fizzlers and foxes by Smith, Kenneth GC

“…Doc number: I5…”
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Resolving mechanisms of immune‐mediated disease in primary CD4 T cells by Bourges, Christophe, Groff, Abigail F, Burren, Oliver S, Gerhardinger, Chiara, Mattioli, Kaia, Hutchinson, Anna, Hu, Theodore, Anand, Tanmay, Epping, Madeline W, Wallace, Chris, Smith, Kenneth GC, Rinn, John L, Lee, James C

“…Deriving mechanisms of immune‐mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently…”
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Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis by Carr, Edward J, Clatworthy, Menna R, Lowe, Christopher E, Todd, John A, Wong, Andrew, Vyse, Timothy J, Kamesh, Lavanya, Watts, Richard A, Lyons, Paul A, Smith, Kenneth G C

“…Autoimmune diseases are complex and have genetic and environmental susceptibility factors. The objective was to test the genetic association of systemic lupus…”
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The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis by WILLCOCKS, Lisa C, LYONS, Paul A, REES, Andrew J, SMITH, Kenneth Gc

“…The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may…”
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T cell exhaustion and immune-mediated disease — the potential for therapeutic exhaustion by McKinney, Eoin F, Smith, Kenneth GC

“…Highlights • T cell exhaustion represents a continuous spectrum of CD8 T cell dysfunction defined in models of chronic viral infection. • It is associated with…”
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FcγRIIB and autoimmunity by Espéli, Marion, Smith, Kenneth G. C., Clatworthy, Menna R.

“…Summary Autoimmune diseases are characterized by adaptive immune responses against self‐antigens, including humoral responses resulting in the production of…”
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Competence and competition: the challenge of becoming a long-lived plasma cell by Hiepe, Falk, Inamine, Ayako, Radbruch, Andreas, Luger, Elke O, Smith, Kenneth G. C, Dörner, Thomas, Muehlinghaus, Gwendolin

“…Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-lived end-stage products of B-cell differentiation that deserve…”
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Genome‐wide association studies in Crohn's disease: Past, present and future by Verstockt, Bram, Smith, Kenneth GC, Lee, James C

“…Over the course of the past decade, genome‐wide association studies (GWAS) have revolutionised our understanding of complex disease genetics. One of the…”
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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes by FERREIRA, Ricardo C, HUI GUO, LYONS, Paul A, SMITH, Kenneth G. C, ACHENBACH, Peter, BEYERLEIN, Andreas, DUNGER, David B, CLAYTON, David G, WICKER, Linda S, TODD, John A, BONIFACIO, Ezio, WALLACE, Chris, COULSON, Richard M. R, ZIEGLER, Anette-G, SMYTH, Deborah J, PEKALSKI, Marcin L, BURREN, Oliver S, CUTLER, Antony J, DOECKE, James D, FLINT, Shaun, MCKINNEY, Eoin F

“…Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost…”
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T‐cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases by McKinney, Eoin F, Smith, Kenneth GC

“…During acute viral infection CD8 T cells rapidly expand before contracting down to a persistent memory population that confers long‐lasting immunity. However…”
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Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression by Xhonneux, Louis-Pascal, Knight, Oliver, Lernmark, Åke, Bonifacio, Ezio, Hagopian, William A, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Parikh, Hemang, Smith, Kenneth G C, Ziegler, Anette-G, Akolkar, Beena, Krischer, Jeffrey P, McKinney, Eoin F

“…Type 1 diabetes (T1D) is a disease of insulin deficiency that results from autoimmune destruction of pancreatic islet β cells. The exact cause of T1D remains…”
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Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia by Fernandez-Egea, Emilio, Vértes, Petra E, Flint, Shaun M, Turner, Lorinda, Mustafa, Syed, Hatton, Alex, Smith, Kenneth G C, Lyons, Paul A, Bullmore, Edward T

“…Hypothetically, psychotic disorders could be caused or conditioned by immunological mechanisms. If so, one might expect there to be peripheral immune system…”
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The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease by Marco, Helena, Smith, Rona M, Jones, Rachel B, Guerry, Mary-Jane, Catapano, Fausta, Burns, Stella, Chaudhry, Afzal N, Smith, Kenneth G C, Jayne, David R W

“…Rituximab is a B cell depleting anti-CD20 monoclonal antibody. CD20 is not expressed on mature plasma cells and accordingly rituximab does not have immediate…”
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microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells by Vigorito, Elena, Perks, Kerry L., Abreu-Goodger, Cei, Bunting, Sam, Xiang, Zou, Kohlhaas, Susan, Das, Partha P., Miska, Eric A., Rodriguez, Antony, Bradley, Allan, Smith, Kenneth G.C., Rada, Cristina, Enright, Anton J., Toellner, Kai-Michael, MacLennan, Ian C.M., Turner, Martin

“…microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination…”
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Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing by Ortiz-Fernández, Lourdes, Carmona, Elio G, Kerick, Martin, Lyons, Paul, Carmona, Francisco David, López Mejías, Raquel, Khor, Chiea Chuen, Grayson, Peter C, Tombetti, Enrico, Jiang, Lindi, Direskeneli, Haner, Saruhan-Direskeneli, Guher, Callejas-Rubio, José-Luis, Vaglio, Augusto, Salvarani, Carlo, Hernández-Rodríguez, Jose, Cid, Maria Cinta, Morgan, Ann W, Merkel, Peter A, Burgner, David, Smith, Kenneth Gc, Gonzalez-Gay, Miguel Angel, Sawalha, Amr H, Martin, Javier, Marquez, Ana

“…The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a…”
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Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease by Peters, James E, Lyons, Paul A, Lee, James C, Richard, Arianne C, Fortune, Mary D, Newcombe, Paul J, Richardson, Sylvia, Smith, Kenneth G C

“…Genome-wide association studies (GWAS) have transformed our understanding of the genetics of complex traits such as autoimmune diseases, but how risk variants…”
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Modules, networks and systems medicine for understanding disease and aiding diagnosis by Gustafsson, Mika, Nestor, Colm E, Zhang, Huan, Barabási, Albert-László, Baranzini, Sergio, Brunak, Sören, Chung, Kian Fan, Federoff, Howard J, Gavin, Anne-Claude, Meehan, Richard R, Picotti, Paola, Pujana, Miguel Àngel, Rajewsky, Nikolaus, Smith, Kenneth Gc, Sterk, Peter J, Villoslada, Pablo, Benson, Mikael

“…Many common diseases, such as asthma, diabetes or obesity, involve altered interactions between thousands of genes. High-throughput techniques (omics) allow…”
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