Search Results - "Smith, Kayla J."
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Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin
Published in Toxicological sciences (01-11-2017)“…Chemokines are components of the skin microenvironment, which enable immune cell chemotaxis. Traditionally, transcription factors involved in inflammatory…”
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Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders
Published in Biochemical pharmacology (01-02-2023)“…[Display omitted] Therapeutic aryl hydrocarbon receptor (AHR) modulating agents gained attention in dermatology as non-steroidal anti-inflammatory drugs that…”
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Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice
Published in Toxicology (Amsterdam) (01-02-2018)“…•Outcrossed SKH1 mice contain several alleles of the Ahr.•SKH1 mice were backcrossed with C57BL6/J mice to obtain the Ahb−1 allele.•SKH1 mouse lines with…”
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Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism
Published in The Journal of pharmacology and experimental therapeutics (01-07-2011)“…The biological functions of the aryl hydrocarbon receptor (AHR) can be delineated into dioxin response element (DRE)-dependent or -independent activities…”
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Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses
Published in Laboratory investigation (01-12-2017)“…The Ah receptor (AHR) has been shown to exhibit both inflammatory and anti-inflammatory activity in a context-specific manner. In vivo macrophage-driven acute…”
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The Role of the Aryl Hydrocarbon Receptor in Modulating Skin and Intestinal Epithelial Physiology
Published 01-01-2017“…Barrier tissues such as the skin and intestine are important for the first line of defense against injury and exposure to potentially harmful toxicants or…”
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Dissertation