Search Results - "Smith, Katherine J."

Lymphatic Vessel Distribution in the Mucosa and Submucosa and Potential Implications for T1 Colorectal Tumors by Smith, Katherine J. E, Jones, Pamela F, Burke, Dermot A, Treanor, Darren, Finan, Paul J, Quirke, Philip

“…PURPOSE:Colorectal cancer spreads to lymph nodes via surrounding lymphatic vasculature. Once this spread has occurred, the prognosis of the patient is…”
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Inhibition of sigma-1 receptor reduces N-methyl- d-aspartate induced neuronal injury in methamphetamine-exposed and -naive hippocampi by Smith, Katherine J., Butler, Tracy R., Prendergast, Mark A.

“…Acute and prolonged methamphetamine (METH) exposure has been reported to moderate the function of N-methyl- d-aspartate type glutamate receptors (NMDAr) in the…”
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HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors by Rumbaugh, Jeffrey A, Bachani, Muznabanu, Li, Wenxue, Butler, Tracy R, Smith, Katherine J, Bianchet, Mario A, Wang, Tongguang, Prendergast, Mark A, Sacktor, Ned, Nath, Avindra

“…Abstract Purpose Human immunodeficiency virus-1 (HIV)-associated neurocognitive disorder (HAND) is a neurodegenerative disease for which there is no available…”
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Increased Efficiency of a Functional SOD Mimic Achieved with Pyridine Modification on a Pyclen-Based Copper(II) Complex by Mekhail, Magy A., Smith, Katherine J., Freire, David M., Pota, Kristof, Nguyen, Nam, Burnett, Marianne E., Green, Kayla N.

“…A series of Cu­(II) complexes with the formula [Cu R PyN 3 ] 2+ varying in substitution on the pyridine ring were investigated as superoxide dismutase (SOD)…”
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Hydrogen Peroxide Disproportionation Activity Is Sensitive to Pyridine Substitutions on Manganese Catalysts Derived from 12-Membered Tetra-Aza Macrocyclic Ligands by Freire, David M., Johnston, Hannah M., Smith, Katherine J., Pota, Kristof, Mekhail, Magy A., Kharel, Sugam, Green, Kayla N.

“…The abundance of manganese in nature and versatility to access different oxidation states have made manganese complexes attractive as catalysts for oxidation…”
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Neonatal quinpirole treatment produces prepulse inhibition deficits in adult male and female rats by Maple, Amanda M., Smith, Katherine J., Perna, Marla K., Brown, Russell W.

“…We have shown that repeated neonatal quinpirole (QUIN; a dopamine D2-like receptor agonist) treatment in rats produces long-lasting supersensitization of…”
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New insights into the lymphovascular microanatomy of the colon and the risk of metastases in pT1 colorectal cancer obtained with quantitative methods and three-dimensional digital reconstruction by Brown, Peter J, Toh, Eu-Wing, Smith, Katherine J E, Jones, Pamela, Treanor, Darren, Magee, Derek, Burke, Dermot, Quirke, Phil

“…Aims UK faecal occult blood test screening has tripled the proportion of pT1 colorectal cancers. The risk of metastasis is predicted by depth of invasion,…”
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Ethanol impairs microtubule formation via interactions at a microtubule associated protein-sensitive site by Smith, Katherine J, Butler, Tracy R, Prendergast, Mark A

“…Abstract Prolonged ethanol abuse has been associated with brain injury caused by impaired synaptogenesis, cellular migration, neurogenesis, and cell signaling,…”
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Neurodegenerative Effects of Recombinant HIV-1 Tat(1-86) are Associated with Inhibition of Microtubule Formation and Oxidative Stress-Related Reductions in Microtubule-Associated Protein-2(a,b) by Butler, Tracy R., Smith, Katherine J., Self, Rachel L., Braden, Brittany B., Prendergast, Mark A.

“…The human immunodeficiency virus 1 (HIV-1) protein Trans-activator of Transcription (Tat) is a nuclear regulatory protein that may contribute to the…”
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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors by Totoritis, Rachel, Duraiswami, Chaya, Taylor, Amy N, Kerrigan, John J, Campobasso, Nino, Smith, Katherine J, Ward, Paris, King, Bryan W, Murrayz-Thompson, Monique, Jones, Amber D, Van Aller, Glenn S, Aubart, Kelly M, Zalacain, Magdalena, Thrall, Sara H, Meek, Thomas D, Schwartz, Benjamin

“…The continual bacterial adaptation to antibiotics creates an ongoing medical need for the development of novel therapeutics. Polypeptide deformylase (PDF) is a…”
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Sex Differences in Caffeine Neurotoxicity Following Chronic Ethanol Exposure and Withdrawal by Butler, Tracy R., Smith, Katherine J., Berry, Jennifer N., Sharrett-Field, Lynda J., Prendergast, Mark A.

“…Aims: Caffeine is a central nervous system stimulant that produces its primary effects via antagonism of the A1 and A2A adenosine receptor subtypes. Previous…”
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Potentiation of N -methyl- d -aspartate receptor-mediated neuronal injury during methamphetamine withdrawal in vitro requires co-activation of IP3 receptors by Smith, Katherine J, Butler, Tracy R, Self, Rachel L, Braden, Brittany B, Prendergast, Mark A

“…Abstract Recent findings suggest that methamphetamine (METH) functions acutely to inhibit N -methyl- d -aspartate (NMDA) receptor function. Protracted…”
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Ethanol Exposure and Withdrawal Sensitizes the Rat Hippocampal CA1 Pyramidal Cell Region to β-Amyloid (25-35)-Induced Cytotoxicity: NMDA Receptor Involvement by Self, Rachel L., Smith, Katherine J., Mulholland, Patrick J., Prendergast, Mark A.

“…: Background: Millions of Americans suffer from Alzheimer's Disease (AD), which is characterized by significant neurological impairment and an accumulation in…”
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Methamphetamine exposure antagonizes N -methyl- d -aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures by Smith, Katherine J, Self, Rachel L, Butler, Tracy R, Mullins, Michael M, Ghayoumi, Layla, Holley, Robert C, Littleton, John M, Prendergast, Mark A

“…Abstract Glutamatergic systems have been increasingly recognized as mediators of methamphetamine's (METH) pharmacological effects though little is known about…”
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Sex Differences in the Neurotoxic Effects of Adenosine A1 Receptor Antagonism During Ethanol Withdrawal: Reversal With an A1 Receptor Agonist or an NMDA Receptor Antagonist by Butler, Tracy R., Smith, Katherine J., Self, Rachel L., Braden, Brittany B., Prendergast, Mark A.

“…Background:  Neuronal adaptations that occur during chronic ethanol (EtOH) exposure have been observed to sensitize the brain to excitotoxic insult during…”
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HLA class I binding motifs derived from random peptide libraries differ at the COOH terminus from those of eluted peptides by Davenport, M P, Smith, K J, Barouch, D, Reid, S W, Bodnar, W M, Willis, A C, Hunt, D F, Hill, A V

“…Recombinant HLA-A2, HLA-B8, or HLA-B53 heavy chain produced in Escherichia coli was combined with recombinant beta2-microglobulin (beta2m) and a pool of…”
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Fast dopamine release events in the nucleus accumbens of early adolescent rats by Robinson, D.L, Zitzman, D.L, Smith, K.J, Spear, L.P

“…Abstract Subsecond fluctuations in dopamine (dopamine transients) in the nucleus accumbens are often time-locked to rewards and cues and provide an important…”
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Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N -methyl- d -asparate-type glutamate receptors by Butler, T.R, Self, R.L, Smith, K.J, Sharrett-Field, L.J, Berry, J.N, Littleton, J.M, Pauly, J.R, Mulholland, P.J, Prendergast, M.A

“…Abstract Excess glutamate release and stimulation of post-synaptic glutamatergic receptors have been implicated in the pathophysiology of many neurological…”
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Sex Differences in the Neurotoxic Effects of Adenosine A 1 Receptor Antagonism During Ethanol Withdrawal: Reversal With an A 1 Receptor Agonist or an NMDA Receptor Antagonist by Butler, Tracy R., Smith, Katherine J., Self, Rachel L., Braden, Brittany B., Prendergast, Mark A.

“…Background:  Neuronal adaptations that occur during chronic ethanol (EtOH) exposure have been observed to sensitize the brain to excitotoxic insult during…”
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Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 transcription factor Tat exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-d-aspartate glutamate receptors to produce persisting spatial learning deficits by Self, Rachel L., Smith, Katherine J., Butler, Tracy R., Pauly, James R., Prendergast, Mark A.

“…Human immunodeficiency virus-1 (HIV-1) infection may produce neurological deficits, such as cognitive decline, that may be worsened by concurrent ethanol…”
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