Search Results - "Smith, KGC"

European consensus statement on the terminology used in the management of lupus glomerulonephritis by Gordon, C, Jayne, D, Pusey, C, Adu, D, Amoura, Z, Aringer, M, Ballerin, J, Cervera, R, Calvo-Alén, J, Chizzolini, C, Dayer, JM, Doria, A, Ferrario, F, Floege, J, Guillevin, L, Haubitz, M, Hiepe, F, Houssiau, F, Lesavre, P, Lightstone, L, Meroni, PL, Meyer, O, Moulin, B, O’Reilly, K, Praga, M, Schulze-Koops, H, Sinico, RA, Smith, KGC, Tincani, A, Vasconcelos, C, Hughes, G

“…Systemic lupus erythematosus (SLE) is a complex, multisystem autoimmune disorder, which often involves referral to multiple medical specialists. Lupus…”
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The generation and maintenance of serum alloantibody by Clatworthy, MR, Espeli, M, Torpey, N, Smith, KGC

“…Donor-specific alloantibodies (DSA) mediate hyperacute and acute antibody-mediated rejection (AMR), which can lead to early graft damage and loss, and are also…”
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B cells in glomerulonephritis: focus on lupus nephritis by Clatworthy, Menna R, Smith, Kenneth G C

“…The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated…”
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Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis by Lee, James C, Lyons, Paul A, McKinney, Eoin F, Sowerby, John M, Carr, Edward J, Bredin, Francesca, Rickman, Hannah M, Ratlamwala, Huzefa, Hatton, Alexander, Rayner, Tim F, Parkes, Miles, Smith, Kenneth G C

“…Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies…”
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The structural basis for serotype-specific neutralization of dengue virus by a human antibody by Teoh, Ee Ping, Kukkaro, Petra, Teo, En Wei, Lim, Angeline P C, Tan, Tze Tong, Yip, Andy, Schul, Wouter, Aung, Myint, Kostyuchenko, Victor A, Leo, Yee Sin, Chan, Soh Ha, Smith, Kenneth G C, Chan, Annie Hoi Yi, Zou, Gang, Ooi, Eng Eong, Kemeny, D Michael, Tan, Grace K, Ng, Jowin K W, Ng, Mah Lee, Alonso, Sylvie, Fisher, Dale, Shi, Pei-Yong, Hanson, Brendon J, Lok, Shee-Mei, MacAry, Paul A

“…Dengue virus (DENV) is a mosquito-borne flavivirus that affects 2.5 billion people worldwide. There are four dengue serotypes (DENV1 to DENV4), and infection…”
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B cell receptor repertoire analysis in six immune-mediated diseases by Bashford-Rogers, RJM, Bergamaschi, L, McKinney, EF, Pombal, DC, Mescia, F, Lee, JC, Thomas, DC, Flint, SM, Kellam, P, Jayne, DRW, Lyons, PA, Smith, KGC

“…B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases (IMDs). Each B cell expresses a single B cell receptor (BCR) 1 ,…”
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FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis by Clatworthy, Menna R., Smith, Kenneth G.C.

“…The immune response to infection must be controlled to ensure it is optimal for defense while avoiding the consequences of excessive inflammation, which…”
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Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts by Floto, R Andres, Clatworthy, Menna R, Heilbronn, Karen R, Rosner, Dalya R, MacAry, Paul A, Rankin, Angela, Lehner, Paul J, Ouwehand, Willem H, Allen, Janet M, Watkins, Nicholas A, Smith, Kenneth G C

“…Dysfunction of receptors for IgG (FcγRs) has been thought to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We show that a recently…”
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Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in antineutrophil cytoplasmic antibody–associated vasculitis by Alberici, Federico, MD, Smith, Rona M., MD, Fonseca, Mariana, PhD, Willcocks, Lisa C., PhD, Jones, Rachel B., MD, Holle, Julia U., PhD, Wieczorek, Stefan, MD, Neumann, Thomas, PhD, Martorana, Davide, PhD, Gregorini, Gina, MD, Sinico, Renato A., MD, Bruchfeld, Annette, PhD, Gunnarsson, Iva, PhD, Ohlsson, Sophie, PhD, Baslund, Bo, PhD, Tesar, Vladimir, PhD, Hruskova, Zdenka, PhD, Cid, Maria C., PhD, Vaglio, Augusto, PhD, Lyons, Paul A., PhD, Smith, Kenneth G.C., PhD, Jayne, David R.W., MD

“…To the Editor: Rituximab is effective at inducing and maintaining remission in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).1,2 The…”
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The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome by Foskolou, Iosifina P., Barbieri, Laura, Vernet, Aude, Bargiela, David, Cunha, Pedro P., Velica, Pedro, Suh, Eunyeong, Pietsch, Sandra, Matuleviciute, Rugile, Rundqvist, Helene, McIntyre, Dominick, Smith, Ken G.C., Johnson, Randall S.

“…Cancer immunotherapy is advancing rapidly and gene-modified T cells expressing chimeric antigen receptors (CARs) show particular promise. A challenge of CAR-T…”
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Alemtuzumab (CAMPATH 1H) Induction Therapy in Cadaveric Kidney Transplantation—Efficacy and Safety at Five Years by Watson, Christopher J. E., Bradley, J. Andrew, Friend, Peter J., Firth, John, Taylor, Craig J., Bradley, John R., Smith, Kenneth G. C., Thiru, Sathia, Jamieson, Neville V., Hale, Geoff, Waldmann, Herman, Calne, Roy

“…Alemtuzumab is a powerful lymphocyte depleting antibody currently being evaluated in solid organ transplantation. This paper describes 5‐year results of a…”
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Rituximab in Churg-Strauss syndrome by Koukoulaki, M, Smith, K G C, Jayne, D R W

“…Churg-Strauss Syndrome (CSS) is a small vessel systemic vasculitis, characterised by asthma, peripheral eosinophilia, neuropathy, pulmonary infiltrates, and…”
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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes by Newton, Kim, Harris, Alan W., Bath, Mary L., Smith, Kenneth G.C., Strasser, Andreas

“…Members of the tumour necrosis factor receptor family that contain a death domain have pleiotropic activities. They induce apoptosis via interaction with…”
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Augmentin-induced jaundice with a fatal outcome by Hebbard, G S, Smith, K G, Gibson, P R, Bhathal, P S

“…To report a case of death due to Augmentin-induced cholestatic hepatitis and discuss a possible drug interaction between Augmentin and oestrogenic steroids. An…”
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De‐functioning polymorphism in the inhibitory receptor FcγRIIB does not impact upon kidney allograft survival by Clatworthy, M. R., Matthews, R., Doehler, B., Willcocks, L., Opelz, G., Smith, K. G. C.

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SIGN-R1 contributes to protection against lethal pneumococcal infection in mice by Lanoue, Astrid, Clatworthy, Menna R, Smith, Philippa, Green, Sheila, Townsend, Michael J, Jolin, Helen E, Smith, Kenneth G C, Fallon, Padraic G, McKenzie, Andrew N J

“…Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific…”
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Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients by Calne, R, Moffatt, S D, Friend, P J, Jamieson, N V, Bradley, J A, Hale, G, Firth, J, Bradley, J, Smith, K G, Waldmann, H

“…Campath 1H is a depleting, humanized anti-CD52 monoclonal antibody that has now been used in 31 renal allograft recipients. The results have been very…”
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Campath 1H allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients by CALNE, R, MOFFATT, S. D, FRIEND, P. J, JAMIESON, N. V, BRADLEY, J. A, HALE, G, FIRTH, J, BRADLEY, J, SMITH, K. G. C, WALDMANN, H

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The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response by Smith, Kenneth G. C., Light, Amanda, Nossal, G. J. V., Tarlinton, David M.

“…Immunization with protein‐containing antigens results in two types of antigen‐specific B cell: antibody forming cells (AFCs) producing antibody of…”
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bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells by Smith, K G, Light, A, O'Reilly, L A, Ang, S M, Strasser, A, Tarlinton, D

“…Immunization with T cell-dependent antigens generates long-lived memory B cells and antibody-forming cells (AFCs). Both populations originate in germinal…”
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