Search Results - "Smith, K.T"

Myeloid AMPK signaling restricts fibrosis but is not required for metformin improvements during CDAHFD-induced NASH in mice by Nunes, Julia R.C., O’Dwyer, Conor, Ghorbani, Peyman, Smith, Tyler K.T., Chauhan, Samarth, Robert-Gostlin, Victoria, Girouard, Madison D., Viollet, Benoit, Foretz, Marc, Fullerton, Morgan D.

“…Metabolic programming underpins inflammation and liver macrophage activation in the setting of chronic liver disease. Here, we sought to identify the role of…”
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Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice by LeBlond, Nicholas D., Ghorbani, Peyman, O'Dwyer, Conor, Ambursley, Nia, Nunes, Julia R.C., Smith, Tyler K.T., Trzaskalski, Natasha A., Mulvihill, Erin E., Viollet, Benoit, Foretz, Marc, Fullerton, Morgan D.

“…The dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage…”
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A Contemporary Report of Clinical Outcomes in Patients with Melanoma Brain Metastases by Phillips, William J, Baghai, Tabassom, Ong, Michael, Lo, Bryan, Ibrahim, Andrea M, Smith, Tyler K T, Song, Xinni

“…Brain metastases are observed in more than 40% of all patients with stage 4 melanoma. In recent years, more extensive use of stereotactic radiation (STRT) and…”
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Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice by Day, Emily A., Townsend, Logan K., Rehal, Sonia, Batchuluun, Battsetseg, Wang, Dongdong, Morrow, Marisa R., Lu, Rachel, Lundenberg, Lucie, Lu, Jessie H., Desjardins, Eric M., Smith, Tyler K.T., Raphenya, Amogelang R., McArthur, Andrew G., Fullerton, Morgan D., Steinberg, Gregory R.

“…Atherosclerotic cardiovascular disease is characterized by both chronic low-grade inflammation and dyslipidemia. The AMP-activated protein kinase (AMPK)…”
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Acidic deposition, cation mobilization, and biochemical indicators of stress in healthy red spruce by Shortle, W.C. (USDA Forest Service, Northeastern Forest Exp. Stn., Durham, NH.), Smith, K.T, Minocha, R, Lawrence, G.B, David, M.B

“…Dendrochemical and biochemical markers link stress in apparently healthy red spruce trees (Picea rubens) to acidic deposition. Acidic deposition to spruce…”
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To catch a chameleon, or actualism vs. natural history in the taphonomy of the microvertebrate fraction at Qesem Cave, Israel by Smith, K.T., Maul, L.C., Barkai, R., Gopher, A.

“…Qesem Cave is a unique Middle Pleistocene, hominin-bearing site in Israel that contains a rich microvertebrate accumulation. The microvertebrates are highly…”
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Microfaunal remains at Middle Pleistocene Qesem Cave, Israel: Preliminary results on small vertebrates, environment and biostratigraphy by Maul, L.C., Smith, K.T., Barkai, R., Barash, A., Karkanas, P., Shahack-Gross, R., Gopher, A.

“…Preliminary results of the investigation of the microfauna at the Acheulo-Yabrudian Middle Pleistocene site of Qesem Cave, Israel, are presented. Thus far the…”
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Evaluation of a stable-isotope labelling technique for mass marking fin rays of age-0 lake sturgeon by SMITH, K.T, WHITLEDGE, G.W

“…Abstract The effectiveness of marking age-0 lake sturgeon, Acipenser fulvescens Rafinesque, pectoral fin rays with a stable strontium isotope was evaluated…”
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General and histopathological results of a two-year study of rats fed semi-purified diets containing casein and soya protein by Anastasia, J V, Braun, B L, Smith, K T

“…Two semi-purified diets, identical except for protein (soya or casein), and a Purina chow diet were fed to groups of Sprague-Dawley rats and compared over a…”
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Does prenylation predict progression in NAFLD? by Ghorbani, Peyman, Smith, Tyler KT, Fullerton, Morgan D

“…Non‐alcoholic fatty liver disease (NAFLD) often develops in concert with related metabolic diseases, such as obesity, dyslipidemia and insulin resistance…”
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THE DIVERGENT BEAM X-RAY TRANSFORM by Hamaker, C., Smith, K. T., Solmon, D. C., Wagner, S. L.

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Jökulhlaups circa landnám: mid- to late first millennium ad floods in south iceland and their implications for landscapes of settlement by Smith, Kate T., Dugmore, Andrew J.

“…This paper presents geomorphological and sedimentological evidence for three large-scale floods to the west of the ice-capped volcano Katla around the time of…”
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AMPK-mediated regulation of endogenous cholesterol synthesis does not affect atherosclerosis in a murine Pcsk9-AAV model by Smith, Tyler K.T., Ghorbani, Peyman, LeBlond, Nicholas D., Nunes, Julia R.C., O'Dwyer, Conor, Ambursley, Nia, Fong-McMaster, Claire, Minarrieta, Lucía, Burkovsky, Leah A., El-Hakim, Rama, Trzaskalski, Natasha A., Locatelli, Cassandra A.A., Stotts, Cameron, Pember, Ciara, Rayner, Katey J., Kemp, Bruce E., Loh, Kim, Harper, Mary-Ellen, Mulvihill, Erin E., St-Pierre, Julie, Fullerton, Morgan D.

“…Dysregulated cholesterol metabolism is a hallmark of atherosclerotic cardiovascular diseases, yet our understanding of how endogenous cholesterol synthesis…”
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Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection by Ghorbani, Peyman, Kim, Sang Yong, Smith, Tyler K T, Minarrieta, Lucía, Robert-Gostlin, Victoria, Kilgour, Marisa K, Ilijevska, Maja, Alecu, Irina, Snider, Shayne A, Margison, Kaitlyn D, Nunes, Julia R C, Woo, Daniel, Pember, Ciara, O'Dwyer, Conor, Ouellette, Julie, Kotchetkov, Pavel, St-Pierre, Julie, Bennett, Steffany A L, Lacoste, Baptiste, Blais, Alexandre, Nair, Meera G, Fullerton, Morgan D

“…Type 2 cytokines like IL-4 are hallmarks of helminth infection and activate macrophages to limit immunopathology and mediate helminth clearance. In addition to…”
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Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments by Stewart, Corina M, Phan, Alexandra, Bo, Yuxia, LeBlond, Nicholas D, Smith, Tyler K T, Laroche, Geneviève, Giguère, Patrick M, Fullerton, Morgan D, Pelchat, Martin, Kobasa, Darwyn, Côté, Marceline

“…Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect…”
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Applied Dendroecology and Environmental Forensics. Characterizing and Age Dating Environmental Releases: Fundamentals and Case Studies by Balouet, Jean-Christophe, Oudijk, Gil, Smith, Kevin T., Petrisor, Ioana, Grudd, Hakan, Stocklassa, Bengt

“…Dendroecology, or the use of ring patterns to assess the age of trees and environmental factors controlling their growth, is a well-developed method in…”
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Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages by Smith, Tyler K T, Kahiel, Zaina, LeBlond, Nicholas D, Ghorbani, Peyman, Farah, Eliya, Al-Awosi, Refel, Cote, Marceline, Gadde, Suresh, Fullerton, Morgan D

“…Activation of the transcription factor liver X receptor (LXR) has beneficial effects on macrophage lipid metabolism and inflammation, making it a potential…”
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Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis by LeBlond, Nicholas D, Nunes, Julia R C, Smith, Tyler K T, O'Dwyer, Conor, Robichaud, Sabrina, Gadde, Suresh, Côté, Marceline, Kemp, Bruce E, Ouimet, Mireille, Fullerton, Morgan D

“…The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics and…”
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Contrasting population characteristics of yellow bass (Morone mississippiensis) in two southern Illinois reservoirs by Smith, K.T, Rude, N.P, Noatch, M.R, Sechler, D.R, Phelps, Q.E, Whitledge, G.W

“…Two southern Illinois reservoirs were investigated with contrasting size structures of yellow bass (Morone mississippiensis) to compare growth, mortality and…”
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Nowcasting precipitation — a proposal for a way forward by Smith, K.T, Austin, G.L

“…There is little doubt that hybrid mesoscale model and image extrapolation systems will eventually become widespread for the nowcasting of precipitation for…”
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