Search Results - "Smith, Joshua J."

Nomograms in oncology: more than meets the eye by Balachandran, Vinod P, Dr, Gonen, Mithat, PhD, Smith, J Joshua, MD, DeMatteo, Ronald P, MD

“…Summary Nomograms are widely used as prognostic devices in oncology and medicine. With the ability to generate an individual probability of a clinical event by…”
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Advances and challenges in treatment of locally advanced rectal cancer by Smith, J Joshua, Garcia-Aguilar, Julio

“…Dramatic improvements in the outcomes of patients with rectal cancer have occurred over the past 30 years. Advances in surgical pathology, refinements in…”
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Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors by Valero, Cristina, Lee, Mark, Hoen, Douglas, Weiss, Kate, Kelly, Daniel W., Adusumilli, Prasad S., Paik, Paul K., Plitas, George, Ladanyi, Marc, Postow, Michael A., Ariyan, Charlotte E., Shoushtari, Alexander N., Balachandran, Vinod P., Hakimi, A. Ari, Crago, Aimee M., Long Roche, Kara C., Smith, J. Joshua, Ganly, Ian, Wong, Richard J., Patel, Snehal G., Shah, Jatin P., Lee, Nancy Y., Riaz, Nadeem, Wang, Jingming, Zehir, Ahmet, Berger, Michael F., Chan, Timothy A., Seshan, Venkatraman E., Morris, Luc G. T.

“…Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients…”
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International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer by Fokas, Emmanouil, Appelt, Ane, Glynne-Jones, Robert, Beets, Geerard, Perez, Rodrigo, Garcia-Aguilar, Julio, Rullier, Eric, Smith, J. Joshua, Marijnen, Corrie, Peters, Femke P., van der Valk, Maxine, Beets-Tan, Regina, Myint, Arthur S., Gerard, Jean-Pierre, Bach, Simon P., Ghadimi, Michael, Hofheinz, Ralf D., Bujko, Krzysztof, Gani, Cihan, Haustermans, Karin, Minsky, Bruce D., Ludmir, Ethan, West, Nicholas P., Gambacorta, Maria A., Valentini, Vincenzo, Buyse, Marc, Renehan, Andrew G., Gilbert, Alexandra, Sebag-Montefiore, David, Rödel, Claus

“…Multimodal treatment strategies for patients with rectal cancer are increasingly including the possibility of organ preservation, through nonoperative…”
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The Paradox of Early Stage Rectal Cancer: More ReSeARCh in the Right Direction by Goffredo, Paolo, Smith, J. Joshua

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A methylation-based prognostic signature in stage II colorectal patients: Considerations for clinical adoption by Romesser, Paul B, Sanchez-Vega, Francisco, Joshua Smith, J

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Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy by Cercek, Andrea, Dos Santos Fernandes, Gustavo, Roxburgh, Campbell S, Ganesh, Karuna, Ng, Shu, Sanchez-Vega, Francisco, Yaeger, Rona, Segal, Neil H, Reidy-Lagunes, Diane L, Varghese, Anna M, Markowitz, Arnold, Wu, Chao, Szeglin, Bryan, Sauvé, Charles-Etienne Gabriel, Salo-Mullen, Erin, Tran, Christina, Patel, Zalak, Krishnan, Asha, Tkachuk, Kaitlyn, Nash, Garrett M, Guillem, Jose, Paty, Philip B, Shia, Jinru, Schultz, Nikolaus, Garcia-Aguilar, Julio, Diaz, Luis A, Goodman, Karyn, Saltz, Leonard B, Weiser, Martin R, Smith, J Joshua, Stadler, Zsofia K

“…Evaluate response of mismatch repair-deficient (dMMR) rectal cancer to neoadjuvant chemotherapy. dMMR rectal tumors at Memorial Sloan Kettering Cancer Center…”
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Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome by Konishi, Tsuyoshi, Shimada, Yoshifumi, Hsu, Meier, Tufts, Lauren, Jimenez-Rodriguez, Rosa, Cercek, Andrea, Yaeger, Rona, Saltz, Leonard, Smith, J Joshua, Nash, Garrett M, Guillem, José G, Paty, Philip B, Garcia-Aguilar, Julio, Gonen, Mithat, Weiser, Martin R

“…Guidelines recommend measuring preoperative carcinoembryonic antigen (CEA) in patients with colon cancer. Although persistently elevated CEA after surgery has…”
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Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma by Lee, Lik Hang, Cavalcanti, Marcela S, Segal, Neil H, Hechtman, Jaclyn F, Weiser, Martin R, Smith, J Joshua, Garcia-Aguilar, Julio, Sadot, Eran, Ntiamoah, Peter, Markowitz, Arnold J, Shike, Moshe, Stadler, Zsofia K, Vakiani, Efsevia, Klimstra, David S, Shia, Jinru

“…Immune checkpoint blockade targeting the programmed death-1 (PD-1) pathway has shown efficacy in several types of cancers including mismatch-repair-deficient…”
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Nonoperative Management for Rectal Cancer by Quezada-Diaz, Felipe F., Smith, J. Joshua

“…The treatment algorithm for locally advanced rectal cancer (LARC) has increased in complexity over the past 10 years. Nonoperative management (NOM) for rectal…”
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MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling by Uppada, Srijayaprakash Babu, Gowrikumar, Saiprasad, Ahmad, Rizwan, Kumar, Balawant, Szeglin, Bryan, Chen, Xi, Smith, J Joshua, Batra, Surinder K, Singh, Amar B, Dhawan, Punita

“…Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies…”
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Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance by Balko, Justin M, Cook, Rebecca S, Vaught, David B, Kuba, María G, Miller, Todd W, Bhola, Neil E, Sanders, Melinda E, Granja-Ingram, Nara M, Smith, J Joshua, Meszoely, Ingrid M, Salter, Janine, Dowsett, Mitch, Stemke-Hale, Katherine, González-Angulo, Ana M, Mills, Gordon B, Pinto, Joseph A, Gómez, Henry L, Arteaga, Carlos L

“…By digital profiling of residual breast tumors after neoadjuvant therapy, the authors identify gene expression patterns that correspond with a higher risk of…”
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SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance by Wasserman, Isaac, Lee, Lik Hang, Ogino, Shuji, Marco, Michael R, Wu, Chao, Chen, Xi, Datta, Jashodeep, Sadot, Eran, Szeglin, Bryan, Guillem, Jose G, Paty, Philip B, Weiser, Martin R, Nash, Garrett M, Saltz, Leonard, Barlas, Afsar, Manova-Todorova, Katia, Uppada, Srijaya Prakash Babu, Elghouayel, Arthur E, Ntiamoah, Peter, Glickman, Jonathan N, Hamada, Tsuyoshi, Kosumi, Keisuke, Inamura, Kentaro, Chan, Andrew T, Nishihara, Reiko, Cercek, Andrea, Ganesh, Karuna, Kemeny, Nancy E, Dhawan, Punita, Yaeger, Rona, Sawyers, Charles L, Garcia-Aguilar, Julio, Giannakis, Marios, Shia, Jinru, Smith, J Joshua

“…SMAD4 has shown promise in identifying patients with colorectal cancer at high risk of recurrence or death. A discovery cohort and independent validation…”
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Incomplete cytoreductive surgery for appendiceal and colorectal peritoneal carcinomatosis: Characteristics and outcomes of an overlooked group by Goffredo, Paolo, Aguirre, Nicole, Mohamed, Mostafa, Kleiman, David A., Cercek, Andrea, Joshua Smith, J., Paty, Philip B., Weiser, Martin, Garcia‐Aguilar, Julio, Nash, Garrett M.

“…Background ond Objectives Complete cytoreductive surgery (CRS) may prolong survival for selected patients with peritoneal carcinomatosis from colorectal cancer…”
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Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer by Datta, Jashodeep, Smith, J Joshua, Chatila, Walid K, McAuliffe, John C, Kandoth, Cyriac, Vakiani, Efsevia, Frankel, Timothy L, Ganesh, Karuna, Wasserman, Isaac, Lipsyc-Sharf, Marla, Guillem, Jose, Nash, Garrett M, Paty, Philip B, Weiser, Martin R, Saltz, Leonard B, Berger, Michael F, Jarnagin, William R, Balachandran, Vinod, Kingham, T Peter, Kemeny, Nancy E, Cercek, Andrea, Garcia-Aguilar, Julio, Taylor, Barry S, Viale, Agnes, Yaeger, Rona, Solit, David B, Schultz, Nikolaus, D'Angelica, Michael I

“…We aimed to investigate genomic correlates underlying extremes of survivorship in metastatic colorectal cancer and their applicability in informing survival in…”
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Total Synthesis of (+)-Fawcettimine by Linghu, Xin, Kennedy-Smith, Joshua J, Toste, F. Dean

“…An effective combination: With the first asymmetric total synthesis of fawcettimine (1) it has been shown that the use of organocatalytic annulation and…”
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Effect of Neoadjuvant Systemic Chemotherapy With or Without Chemoradiation on Bowel Function in Rectal Cancer Patients Treated With Total Mesorectal Excision by Quezada-Diaz, Felipe, Jimenez-Rodriguez, Rosa M., Pappou, Emmanouil P., Smith, J. Joshua, Patil, Sujata, Wei, Iris, Guillem, Jose G., Paty, Philip B., Nash, Garrett M., Weiser, Martin R., Garcia-Aguilar, Julio

“…Background Neoadjuvant chemoradiation (CRT) impairs bowel function in patients with rectal cancer treated with total mesorectal excision (TME). The impact of…”
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Chain Walking of Allylrhodium Species Towards Esters During Rhodium-Catalyzed Nucleophilic Allylations of Imines by Martínez, Jose I., Smith, Joshua J., Hepburn, Hamish B., Lam, Hon Wai

“…Allylrhodium species derived from δ‐trifluoroboryl β,γ‐unsaturated esters undergo chain walking towards the ester moiety. The resulting allylrhodium species…”
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Claudin-1 Up-regulates the Repressor ZEB-1 to Inhibit E-Cadherin Expression in Colon Cancer Cells by Singh, Amar B, Sharma, Ashok, Smith, J. Joshua, Krishnan, Moorthy, Chen, Xi, Eschrich, Steven, Washington, Mary K, Yeatman, Timothy J, Beauchamp, R. Daniel, Dhawan, Punita

“…Background & Aims Expression of the tight junction protein claudin-1 is dysregulated in colon tumors and associates with their progression. Up-regulation of…”
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Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials by Fokas, Emmanouil, Williams, Hannah, Diefenhardt, Markus, Lin, Sabrina, Qin, Li-Xuan, Piso, Pompiliu, Dapper, Hendrik, Germer, Christoph-Thomas, Grützmann, Robert, Tim Friede, J., Joshua Smith, J., Saltz, Leonard B., Wu, Abraham J., Weiser, Martin R., Omer, Dana, Ghadimi, Michael, Hofheinz, Ralf-Dieter, Garcia-Aguilar, Julio, Rödel, Claus

“…Total neoadjuvant therapy (TNT) has been used for patients with locally advanced rectal cancer. The optimal sequence of chemoradiotherapy (CRT) and…”
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