Search Results - "Smith, Jennifer J"

Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
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The insecticidal potential of venom peptides by Smith, Jennifer J., Herzig, Volker, King, Glenn F., Alewood, Paul F.

“…Pest insect species are a burden to humans as they destroy crops and serve as vectors for a wide range of diseases including malaria and dengue. Chemical…”
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True Lies: Using Proteomics to Assess the Accuracy of Transcriptome-Based Venomics in Centipedes Uncovers False Positives and Reveals Startling Intraspecific Variation in Scolopendra Subspinipes by Smith, Jennifer J, Undheim, Eivind A B

“…Centipede venoms have emerged as a rich source of novel bioactive compounds. However, most centipede species are commonly considered too small for venom…”
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Evidence that auxin is required for normal seed size and starch synthesis in pea by McAdam, Erin L., Meitzel, Tobias, Quittenden, Laura J., Davidson, Sandra E., Dalmais, Marion, Bendahmane, Abdelhafid I., Thompson, Richard, Smith, Jennifer J., Nichols, David S., Urquhart, Shelley, Gélinas‐Marion, Ariane, Aubert, Gregoire, Ross, John J.

“…In recent years the biosynthesis of auxin has been clarified with the aid of mutations in auxin biosynthesis genes. However, we know little about the effects…”
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Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast by Wang, Zhuo, Danziger, Samuel A, Heavner, Benjamin D, Ma, Shuyi, Smith, Jennifer J, Li, Song, Herricks, Thurston, Simeonidis, Evangelos, Baliga, Nitin S, Aitchison, John D, Price, Nathan D

“…Gene regulatory and metabolic network models have been used successfully in many organisms, but inherent differences between them make networks difficult to…”
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A bivalent remipede toxin promotes calcium release via ryanodine receptor activation by Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B., Mobli, Mehdi

“…Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights into channel structure and pharmacology…”
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GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance by Atif, Mohammed, Smith, Jennifer J, Estrada-Mondragon, Argel, Xiao, Xue, Salim, Angela A, Capon, Robert J, Lynch, Joseph W, Keramidas, Angelo

“…Glutamate-gated chloride channel receptors (GluClRs) mediate inhibitory neurotransmission at invertebrate synapses and are primary targets of parasites that…”
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Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif by Smith, Jennifer J, Hill, Justine M, Little, Michelle J, Nicholson, Graham M, King, Glenn F, Alewood, Paul F

“…The three-disulfide inhibitor cystine knot (ICK) motif is a fold common to venom peptides from spiders, scorpions, and aquatic cone snails. Over a decade ago…”
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A Data Integration Methodology for Systems Biology by Daehee Hwang, Rust, Alistair G., Stephen Ramsey, Smith, Jennifer J., Deena M. Leslie, Weston, Andrea D., Pedro de Atauri, Aitchison, John D., Hood, Leroy, Siegel, Andrew F., Bolouri, Hamid

“…Different experimental technologies measure different aspects of a system and to differing depth and breadth. High-throughput assays have inherently high…”
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Peroxisomes take shape by Smith, Jennifer J., Aitchison, John D.

“…Key Points Peroxisomes are dynamic and diverse organelles that are found in nearly all eukaryotic cells, and the disruption of their function is linked to…”
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Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins by Smith, Jennifer J., Vetter, Irina, Lewis, Richard J., Peigneur, Steve, Tytgat, Jan, Lam, Alexander, Gallant, Esther M., Beard, Nicole A., Alewood, Paul F., Dulhunty, Angela F.

“…We recently reported the isolation of a scorpion toxin named U₁-liotoxin-Lw1a (U₁-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed…”
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The potential for estradiol and ethinylestradiol degradation in english rivers by Jürgens, Monika D., Holthaus, Karlijn I. E., Johnson, Andrew C., Smith, Jennifer J. L., Hetheridge, Malcom, Williams, Richard J.

“…Water samples were collected in spring, summer, and winter from English rivers in urban/industrial (River Aire and River Calder, Yorkshire, UK) and rural…”
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Role of the Histone Variant H2A.Z/Htz1p in TBP Recruitment, Chromatin Dynamics, and Regulated Expression of Oleate-Responsive Genes by Wan, Yakun, Saleem, Ramsey A., Ratushny, Alexander V., Roda, Oriol, Smith, Jennifer J., Lin, Chan-Hsien, Chiang, Jung-Hsien, Aitchison, John D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An indicator cell assay for blood-based diagnostics by Danziger, Samuel A, Miller, Leslie R, Singh, Karanbir, Whitney, G Adam, Peskind, Elaine R, Li, Ge, Lipshutz, Robert J, Aitchison, John D, Smith, Jennifer J

“…We have established proof of principle for the Indicator Cell Assay Platform™ (iCAP™), a broadly applicable tool for blood-based diagnostics that uses…”
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The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells by Wilson, David, Boyle, Glen M, McIntyre, Lachlan, Nolan, Matthew J, Parsons, Peter G, Smith, Jennifer J, Tribolet, Leon, Loukas, Alex, Liddell, Michael J, Rash, Lachlan D, Daly, Norelle L

“…Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in…”
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A Data Integration Methodology for Systems Biology: Experimental Verification by Daehee Hwang, Smith, Jennifer J., Deena M. Leslie, Weston, Andrea D., Rust, Alistair G., Stephen Ramsey, Pedro de Atauri, Siegel, Andrew F., Bolouri, Hamid, Aitchison, John D., Hood, Leroy

“…The integration of data from multiple global assays is essential to understanding dynamic spatiotemporal interactions within cells. In a companion paper, we…”
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Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast by Smith, Jennifer J, Petersen, Timothy W, de Atauri, Pedro, Ramsey, Stephen A, Bolouri, Hamid, Aitchison, John D, Orrell, David, Marelli, Marcello

“…Transcriptional noise is known to be an important cause of cellular heterogeneity and phenotypic variation. The extent to which molecular interaction networks…”
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Innovative Approaches to Emergency Medical Services Fellowship Challenges by Weston, Benjamin W, Gaither, Joshua, Schulz, Kevin, Srinivasan, Saranya, Smith, Jennifer J, Colella, M Riccardo

“…Since the development of an Accreditation Council of Graduate Medical Education (ACGME)-accredited emergency medical services (EMS) fellowship, there has been…”
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Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells by Giribaldi, Julien, Smith, Jennifer J., Schroeder, Christina I.

“…Animal venoms are a rich source of bioactive peptides that efficiently modulate key receptors and ion channels involved in cellular excitability to rapidly…”
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One-Cell Doubling Evaluation by Living Arrays of Yeast, ODELAY by Herricks, Thurston, Dilworth, David J, Mast, Fred D, Li, Song, Smith, Jennifer J, Ratushny, Alexander V, Aitchison, John D

“…Cell growth is a complex phenotype widely used in systems biology to gauge the impact of genetic and environmental perturbations. Due to the magnitude of…”
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