Search Results - "Smith, Jeffrey W."

Mass Spectrometry-Based Label-Free Quantitative Proteomics by Zhu, Wenhong, Smith, Jeffrey W., Huang, Chun-Ming

“…In order to study the differential protein expression in complex biological samples, strategies for rapid, highly reproducible and accurate quantification are…”
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Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies by Jeon, Young Joo, Khelifa, Sihem, Ratnikov, Boris, Scott, David A., Feng, Yongmei, Parisi, Fabio, Ruller, Chelsea, Lau, Eric, Kim, Hyungsoo, Brill, Laurence M., Jiang, Tingting, Rimm, David L., Cardiff, Robert D., Mills, Gordon B., Smith, Jeffrey W., Osterman, Andrei L., Kluger, Yuval, Ronai, Ze’ev A.

“…Many tumor cells are fueled by altered metabolism and increased glutamine (Gln) dependence. We identify regulation of the L-glutamine carrier proteins SLC1A5…”
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Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis by Toledo, Alejandro Gómez, Golden, Gregory, Campos, Alexandre Rosa, Cuello, Hector, Sorrentino, James, Lewis, Nathan, Varki, Nissi, Nizet, Victor, Smith, Jeffrey W., Esko, Jeffrey D.

“…Sepsis is a life-threatening condition triggered by a dysregulated host response to microbial infection resulting in vascular dysfunction, organ failure and…”
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One-Step Fabrication of Polymeric Janus Nanoparticles for Drug Delivery by Xie, Hui, She, Zhi-Gang, Wang, Si, Sharma, Gaurav, Smith, Jeffrey W

“…With its unique structure of two compartments, Janus particles can be used for many applications for which monomorphic particles are inadequate, including to…”
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An intrinsic mechanism of secreted protein aging and turnover by Yang, Won Ho, Aziz, Peter V., Heithoff, Douglas M., Mahan, Michael J., Smith, Jeffrey W., Marth, Jamey D.

“…The composition and functions of the secreted proteome are controlled by the life spans of different proteins. However, unlike intracellular protein fate,…”
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Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation by Fogal, Valentina, Richardson, Adam D., Karmali, Priya P., Scheffler, Immo E., Smith, Jeffrey W., Ruoslahti, Erkki

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood by Doshi, Nishit, Orje, Jennifer N., Molins, Blanca, Smith, Jeffrey W., Mitragotri, Samir, Ruggeri, Zaverio M.

“…Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic…”
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Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing by Ersoy, Selvi C., Heithoff, Douglas M., Barnes, Lucien, Tripp, Geneva K., House, John K., Marth, Jamey D., Smith, Jeffrey W., Mahan, Michael J.

“…The emergence and prevalence of antibiotic-resistant bacteria are an increasing cause of death worldwide, resulting in a global ‘call to action’ to avoid…”
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Basis for substrate recognition and distinction by matrix metalloproteinases by Ratnikov, Boris I, Cieplak, Piotr, Gramatikoff, Kosi, Pierce, James, Eroshkin, Alexey, Igarashi, Yoshinobu, Kazanov, Marat, Sun, Qing, Godzik, Adam, Osterman, Andrei, Stec, Boguslaw, Strongin, Alex, Smith, Jeffrey W

“…Significance Specificity-determining positions (SDPs) account for distinctions in function across a protein family. Many theories on the evolution of…”
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Quantitative profiling of protease specificity by Ratnikov, Boris I, Cieplak, Piotr, Remacle, Albert G, Nguyen, Elise, Smith, Jeffrey W

“…Proteases are an important class of enzymes, whose activity is central to many physiologic and pathologic processes. Detailed knowledge of protease specificity…”
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Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells by Filipp, Fabian V., Scott, David A., Ronai, Ze'ev A., Osterman, Andrei L., Smith, Jeffrey W.

“…Summary The tricarboxylic acid (TCA) cycle is the central hub of oxidative metabolism, running in the classic forward direction to provide carbon for…”
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Functional specialization in proline biosynthesis of melanoma by De Ingeniis, Jessica, Ratnikov, Boris, Richardson, Adam D, Scott, David A, Aza-Blanc, Pedro, De, Surya K, Kazanov, Marat, Pellecchia, Maurizio, Ronai, Ze'ev, Osterman, Andrei L, Smith, Jeffrey W

“…Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis…”
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Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system by Xie, Hui, Smith, Jeffrey W

“…Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life, cellular uptake and…”
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Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4 by Knowles, Lynn M., Yang, Chen, Osterman, Andrei, Smith, Jeffrey W.

“…Fatty-acid synthase (FAS) is up-regulated in a broad range of cancers, including those of the breast, prostate, and ovaries. In tumor cells, the inhibition of…”
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CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events by Kumar, Sonu, Ratnikov, Boris I, Kazanov, Marat D, Smith, Jeffrey W, Cieplak, Piotr

“…CleavPredict (http://cleavpredict.sanfordburnham.org) is a Web server for substrate cleavage prediction for matrix metalloproteinases (MMPs). It is intended as…”
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Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis by Zielinski, Daniel C., Filipp, Fabian V., Bordbar, Aarash, Jensen, Kasper, Smith, Jeffrey W., Herrgard, Markus J., Mo, Monica L., Palsson, Bernhard O.

“…Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely…”
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Profiling constitutive proteolytic events in vivo by Timmer, John C, Enoksson, Mari, Wildfang, Eric, Zhu, Wenhong, Igarashi, Yoshinobu, Denault, Jean-Benard, Ma, Yuliang, Dummitt, Benjamin, Chang, Yie-Hwa, Mast, Alan E, Eroshkin, Alexey, Smith, Jeffrey W, Tao, W Andy, Salvesen, Guy S

“…Most known organisms encode proteases that are crucial for constitutive proteolytic events. In the present paper, we describe a method to define these events…”
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Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis by Shiryaev, Sergey A, Savinov, Alexei Y, Cieplak, Piotr, Ratnikov, Boris I, Motamedchaboki, Khatereh, Smith, Jeffrey W, Strongin, Alex Y

“…Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple…”
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Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network by Pimienta, Genaro, Heithoff, Douglas M., Rosa‐Campos, Alexandre, Tran, Minerva, Esko, Jeffrey D., Mahan, Michael J., Marth, Jamey D., Smith, Jeffrey W.

“…Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise…”
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Coagulation factor protein abundance in the pre-septic state predicts coagulopathic activities that arise during late-stage murine sepsis by Heithoff, Douglas M., Pimienta, Genaro, Mahan, Scott P., Yang, Won Ho, Le, Dzung T., House, John K., Marth, Jamey D., Smith, Jeffrey W., Mahan, Michael J.

“…Although sepsis accounts for 1 in 5 deaths globally, few molecular therapies exist for this condition. The development of effective biomarkers and treatments…”
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