Search Results - "Smith, Jeffrey S."

Simulation for manufacturing system design and operation: Literature review and analysis by Negahban, Ashkan, Smith, Jeffrey S.

“…•We provide a comprehensive review of articles involving simulation in manufacturing.•Comparison of results from 2002 to 2013 with previous review results.•The…”
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The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae by Gartenberg, Marc R, Smith, Jeffrey S

“…Transcriptional silencing in Saccharomyces cerevisiae occurs at several genomic sites including the silent mating-type loci, telomeres, and the ribosomal DNA…”
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Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III by Dinda, Manikarna, Fine, Ryan D, Saha, Shekhar, Wang, Zhenjia, Zang, Chongzhi, Li, Mingguang, Smith, Jeffrey S

“…Despite recent advances in single-molecule and structural analysis of condensin activity in vitro, mechanisms of functional condensin loading and loop…”
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Molecular Characterization of Nitrogen-Containing Organic Compounds in Biomass Burning Aerosols Using High-Resolution Mass Spectrometry by Laskin, Alexander, Smith, Jeffrey S, Laskin, Julia

“…Although nitrogen-containing organic compounds (NOC) are important components of atmospheric aerosols, little is known about their chemical composition. Here…”
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A microarray-based genetic screen for yeast chronological aging factors by Matecic, Mirela, Smith, Daniel L, Pan, Xuewen, Maqani, Nazif, Bekiranov, Stefan, Boeke, Jef D, Smith, Jeffrey S

“…Model organisms have played an important role in the elucidation of multiple genes and cellular processes that regulate aging. In this study we utilized the…”
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A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure by Li, Mingguang, Fine, Ryan D, Dinda, Manikarna, Bekiranov, Stefan, Smith, Jeffrey S

“…The NAD+-dependent histone deacetylase Sir2 was originally identified in Saccharomyces cerevisiae as a silencing factor for HML and HMR, the heterochromatic…”
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Caloric Restriction Extends Yeast Chronological Life Span by Optimizing the Snf1 (AMPK) Signaling Pathway by Wierman, Margaret B., Maqani, Nazif, Strickler, Erika, Li, Mingguang, Smith, Jeffrey S.

“…AMP-activated protein kinase (AMPK) and the homologous yeast SNF1 complex are key regulators of energy metabolism that counteract nutrient deficiency and ATP…”
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Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive by Lemos, Julia C., Wanat, Matthew J., Smith, Jeffrey S., Reyes, Beverly A. S., Hollon, Nick G., Van Bockstaele, Elisabeth J., Chavkin, Charles, Phillips, Paul E. M.

“…The neuropeptide corticotropin-releasing factor (CRF) acts in the nucleus accumbens of mice to increase dopamine release through coactivation of CRF receptor 1…”
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Location bias contributes to functionally selective responses of biased CXCR3 agonists by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Pham, Uyen, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey S., Zhang, Jennifer Y., Rajagopal, Sudarshan

“…Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially activate specific signaling transducers over others. Although GPCRs…”
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Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement by Xu, Zhili, Qiu, Qi, Tian, Jie, Smith, Jeffrey S, Conenello, Gina M, Morita, Takashi, Byrnes, Andrew P

“…Understanding how adenoviruses transduce cells is important for their use and development as vaccine vectors. Adenovirus type 5 (Ad5) is known to bind…”
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Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement by Xu, Zhili, Tian, Jie, Smith, Jeffrey S, Byrnes, Andrew P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways by Smith, Jeffrey S, Alagesan, Priya, Desai, Nimit K, Pack, Thomas F, Wu, Jiao-Hui, Inoue, Asuka, Freedman, Neil J, Rajagopal, Sudarshan

“…Biased agonism, the ability of different ligands for the same receptor to selectively activate some signaling pathways while blocking others, is now an…”
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From pre-test and post-test probabilities to medical decision making by Nixon, Michelle Pistner, Momotaz, Farhani, Smith, Claire, Smith, Jeffrey S, Sendak, Mark, Polage, Christopher, Silverman, Justin D

“…A central goal of modern evidence-based medicine is the development of simple and easy to use tools that help clinicians integrate quantitative information…”
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Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD by Belenky, Peter, Racette, Frances G., Bogan, Katrina L., McClure, Julie M., Smith, Jeffrey S., Brenner, Charles

“…Although NAD + biosynthesis is required for Sir2 functions and replicative lifespan in yeast, alterations in NAD + precursors have been reported to accelerate…”
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Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of Saccharomyces cerevisiae by Fine, Ryan D, Maqani, Nazif, Li, Mingguang, Franck, Elizabeth, Smith, Jeffrey S

“…Sir2 is a highly conserved NAD -dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the…”
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Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies by Smith, Jeffrey S, Rajagopal, Sudarshan, Atwater, Amber Reck

“…Allergic contact dermatitis (ACD) is a common skin disease that results in significant cost and morbidity. Despite its high prevalence, therapeutic options are…”
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Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation by Smith, Jeffrey S, Nicholson, Lowell T, Suwanpradid, Jutamas, Glenn, Rachel A, Knape, Nicole M, Alagesan, Priya, Gundry, Jaimee N, Wehrman, Thomas S, Atwater, Amber Reck, Gunn, Michael D, MacLeod, Amanda S, Rajagopal, Sudarshan

“…The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting…”
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The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors by Smith, Jeffrey S., Rajagopal, Sudarshan

“…The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors…”
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Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake by Schindler, Abigail G, Messinger, Daniel I, Smith, Jeffrey S, Shankar, Haripriya, Gustin, Richard M, Schattauer, Selena S, Lemos, Julia C, Chavkin, Nicholas W, Hagan, Catherine E, Neumaier, John F, Chavkin, Charles

“…Activation of the dynorphin/κ-opioid receptor (KOR) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and…”
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Molecular Characterization of Biomass Burning Aerosols Using High-Resolution Mass Spectrometry by Smith, Jeffrey S, Laskin, Alexander, Laskin, Julia

“…Chemical characterization of atmospheric aerosols presents a serious analytical challenge because of the complexity of particulate matter analyte composed of a…”
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