Search Results - "Smith, Jayden"

Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication by Pluchino, Stefano, Smith, Jayden A.

“…There is growing interest surrounding the diagnostic and therapeutic potential of exosomes, but a definitive description of these extracellular vesicles…”
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Neural stem cells traffic functional mitochondria via extracellular vesicles by Peruzzotti-Jametti, Luca, Bernstock, Joshua D, Willis, Cory M, Manferrari, Giulia, Rogall, Rebecca, Fernandez-Vizarra, Erika, Williamson, James C, Braga, Alice, van den Bosch, Aletta, Leonardi, Tommaso, Krzak, Grzegorz, Kittel, Ágnes, Benincá, Cristiane, Vicario, Nunzio, Tan, Sisareuth, Bastos, Carlos, Bicci, Iacopo, Iraci, Nunzio, Smith, Jayden A, Peacock, Ben, Muller, Karin H, Lehner, Paul J, Buzas, Edit Iren, Faria, Nuno, Zeviani, Massimo, Frezza, Christian, Brisson, Alain, Matheson, Nicholas J, Viscomi, Carlo, Pluchino, Stefano

“…Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous…”
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Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis by Pluchino, Stefano, Smith, Jayden A., Peruzzotti-Jametti, Luca

“…Multiple disease-modifying medications with regulatory approval to treat multiple sclerosis (MS) are unable to prevent inflammatory tissue damage in the…”
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Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair by Marchetti, Bianca, Tirolo, Cataldo, L'Episcopo, Francesca, Caniglia, Salvatore, Testa, Nunzio, Smith, Jayden A., Pluchino, Stefano, Serapide, Maria F.

“…A common hallmark of age‐dependent neurodegenerative diseases is an impairment of adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site…”
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Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation by Krzak, Grzegorz, Willis, Cory M., Smith, Jayden A., Pluchino, Stefano, Peruzzotti-Jametti, Luca

“…The rapidly evolving area of immunometabolism has shed new light on the fundamental properties of products and intermediates of cellular metabolism…”
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Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand by Hall, James P, O’Sullivan, Kyra, Naseer, Abeer, Smith, Jayden A, Kelly, John M, Cardin, Christine J

“…We describe a crystal structure, at atomic resolution (1.1 Å, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a…”
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Stem Cell Therapies for Progressive Multiple Sclerosis by Smith, Jayden A., Nicaise, Alexandra M., Ionescu, Rosana-Bristena, Hamel, Regan, Peruzzotti-Jametti, Luca, Pluchino, Stefano

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients…”
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Quantitative high‐throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO‐specific protease (SENP)2 by Bernstock, Joshua D., Ye, Daniel, Smith, Jayden A., Lee, Yang‐Ja, Gessler, Florian A., Yasgar, Adam, Kouznetsova, Jennifer, Jadhav, Ajit, Wang, Zhuoran, Pluchino, Stefano, Zheng, Wei, Simeonov, Anton, Hallenbeck, John M., Yang, Wei

“…The development of novel neuroprotective treatments for acute stroke has been fraught with failures, which supports the view of ischemic brain damage as a…”
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Supramolecular approach to enantioselective DNA recognition using enantiomerically resolved cationic 4-amino-1,8-naphthalimide-based Tröger's bases by Banerjee, Swagata, Bright, Sandra A, Smith, Jayden A, Burgeat, Jeremy, Martinez-Calvo, Miguel, Williams, D Clive, Kelly, John M, Gunnlaugsson, Thorfinnur

“…The synthesis and photophysical studies of two cationic Tröger's base (TB)-derived bis-naphthalimides 1 and 2 and the TB derivative 6, characterized by X-ray…”
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Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles by Islam, Yamir, Leach, Andrew G., Smith, Jayden, Pluchino, Stefano, Coxon, Christopher R., Sivakumaran, Muttuswamy, Downing, James, Fatokun, Amos A., Teixidò, Meritxell, Ehtezazi, Touraj

“…The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is known to be increasing due to an aging population and is anticipated…”
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RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity by Smith, Jayden A., Braga, Alice, Verheyen, Jeroen, Basilico, Silvia, Bandiera, Sara, Alfaro-Cervello, Clara, Peruzzotti-Jametti, Luca, Shu, Dan, Haque, Farzin, Guo, Peixuan, Pluchino, Stefano

“…In response to injuries to the CNS, astrocytes enter a reactive state known as astrogliosis, which is believed to be deleterious in some contexts. Activated…”
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Extracellular membrane vesicles and immune regulation in the brain by Cossetti, Chiara, Smith, Jayden A, Iraci, Nunzio, Leonardi, Tommaso, Alfaro-Cervello, Clara, Pluchino, Stefano

“…The brain is characterized by a complex and integrated network of interacting cells in which cell-to-cell communication is critical for proper development and…”
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Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA by Vasudevan, Suni, Smith, Jayden A, Wojdyla, Michal, DiTrapani, A, Kruger, P E, McCabe, Thomas, Fletcher, Nicholas C, Quinn, Susan J, Kelly, John M

“…[Cr(phen)(2)(X(2)dppz)](3+) {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Delta and Lambda…”
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Microwave synthesis of a rare [Ru(2)L(3)](4+) triple helicate and its interaction with DNA by Glasson, Christopher R K, Meehan, George V, Clegg, Jack K, Lindoy, Leonard F, Smith, Jayden A, Keene, F Richard, Motti, Cherie

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Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2 by Cao, Qian, Creely, Caitriona M, Davies, E Stephen, Dyer, Joanne, Easun, Timothy L, Grills, David C, McGovern, David A, McMaster, Jonathan, Pitchford, Jonathan, Smith, Jayden A, Sun, Xue-Zhong, Kelly, John M, George, Michael W

“…The transient species formed following excitation of fac-[Re(CO)(3)(F(2)dppz)(py)](+) (F(2)dppz = 11,12-difluorodipyrido[3,2-a:2',3'-c]phenazine) bound to…”
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Separation of stereoisomers of dinuclear metal complexes by binding affinity chromatography using non-duplex DNA by Smith, Jayden A, Keene, F Richard

“…Affinity chromatography--using non-duplex DNA as the affinity ligand--has been used as a highly efficient means of separating stereoisomers of dinuclear…”
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Dinuclear ruthenium(ii) complexes with flexible bridges as non-duplex DNA binding agents by Morgan, Joy L, Spillane, Caitriona B, Smith, Jayden A, Buck, Damian P, Collins, J Grant, Keene, F Richard

“…The stereoisomers of a series of dinuclear ruthenium(ii) complexes [{Ru(phen)(2)}(2)(micro-BL)](4+) (phen = 1,10-phenanthroline) with flexible bridging ligands…”
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Excited state behaviour of substituted dipyridophenazine Cr(III) complexes in the presence of nucleic acids by Wojdyla, Michal, Smith, Jayden A, Vasudevan, Suni, Quinn, Susan J, Kelly, John M

“…The photophysics and photochemistry of [Cr(phen)(2)(dppz)](3+) and its 11,12-substituted derivatives [Cr(phen)(2)(X(2)dppz)](3+) {X = Me or F} have been…”
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Dinuclear ruthenium(II) complexes as potential probes for RNA bulge sites by Spillane, Caitriona B, Smith, Jayden A, Buck, Damian P, Collins, J Grant, Keene, F Richard

“…1H NMR spectroscopy and molecular modelling have been used to investigate the binding of the DeltaDelta-and LambdaLambda-enantiomers of the dinuclear…”
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DNA affinity binding studies using a fluorescent dye displacement technique: the dichotomy of the binding site by Spillane, Caitriona B, Smith, Jayden A, Morgan, Joy L, Keene, F Richard

“…We have observed a number of discrepancies and contradictions in the use of a fluorescent intercalator displacement assay in surveying the binding affinities…”
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