Search Results - "Smith, Graham R"

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis by Carroll, Bernadette, Otten, Elsje G., Manni, Diego, Stefanatos, Rhoda, Menzies, Fiona M., Smith, Graham R., Jurk, Diana, Kenneth, Niall, Wilkinson, Simon, Passos, Joao F., Attems, Johannes, Veal, Elizabeth A., Teyssou, Elisa, Seilhean, Danielle, Millecamps, Stéphanie, Eskelinen, Eeva-Liisa, Bronowska, Agnieszka K., Rubinsztein, David C., Sanz, Alberto, Korolchuk, Viktor I.

“…Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic…”
Get full text

Natural environments and chronic stress measured by hair cortisol by Gidlow, Christopher J., Randall, Jason, Gillman, Jamie, Smith, Graham R., Jones, Marc V.

“…•Hair cortisol concentration (HCC) is a novel, non-invasive biomarker of chronic stress.•We explored natural environment in neighbourhoods and…”
Get full text

Genome‐Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR‐140‐5p by Barter, Matt J., Tselepi, Maria, Gómez, Rodolfo, Woods, Steven, Hui, Wang, Smith, Graham R., Shanley, Daryl P., Clark, Ian M., Young, David A.

“…microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are…”
Get full text

Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis by Shmarov, Fedor, Smith, Graham R, Weatherhead, Sophie C, Reynolds, Nick J, Zuliani, Paolo

“…Despite increased understanding about psoriasis pathophysiology, currently there is a lack of predictive computational models. We developed a personalisable…”
Get full text

The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis by Barron‐Millar, Ben, Ogle, Laura, Mells, George, Flack, Steven, Badrock, Jonathan, Sandford, Richard, Kirby, John, Palmer, Jeremy, Jopson, Laura, Brain, John, Smith, Graham R., Rushton, Steve, Hegade, Vinod S., Jones, Rebecca, Rushbrook, Simon, Thorburn, Douglas, Ryder, Steve, Hirschfield, Gideon, Dyson, Jessica K., Jones, David E.J.

“…Background and Aims Stratified therapy has entered clinical practice in primary biliary cholangitis (PBC), with routine use of second‐line therapy in…”
Get full text

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity by Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver Dk, Otten, Gisela, Ratcliff, Matthew, Smith, Graham R, Dunlop, Elaine A, Passos, João F, Davies, Owen R, Jaenisch, Rudolf, Tee, Andrew R, Sarkar, Sovan, Korolchuk, Viktor I

“…The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health…”
Get full text

Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis by Proctor, Carole J, Smith, Graham R

“…The aim of this study was to show how computational models can be used to increase our understanding of the role of microRNAs in osteoarthritis (OA) using…”
Get full text

An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression by Siachisumo, Chileleko, Luzzi, Sara, Aldalaqan, Saad, Hysenaj, Gerald, Dalgliesh, Caroline, Cheung, Kathleen, Gazzara, Matthew R, Yonchev, Ivaylo D, James, Katherine, Kheirollahi Chadegani, Mahsa, Ehrmann, Ingrid E, Smith, Graham R, Cockell, Simon J, Munkley, Jennifer, Wilson, Stuart A, Barash, Yoseph, Elliott, David J

“…Previously, we showed that the germ cell-specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility…”
Get full text

Prediction of protein–protein interactions by docking methods by Smith, Graham R., Sternberg, Michael J.E.

“…Recently, developments have been made in predicting the structure of docked complexes when the coordinates of the components are known. The process generally…”
Get full text

Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis by Addison, Rachel, Weatherhead, Sophie C., Pawitri, Anandika, Smith, Graham R., Rider, Ashley, Grantham, Henry J., Cockell, Simon J., Reynolds, Nick J.

“…Ultraviolet B radiation (UVB) exerts pleiotropic effects on human skin. DNA damage response and repair pathways are activated by UVB; if damage cannot be…”
Get full text

Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways by Smith, Graham R, Shanley, Daryl P

“…FOXO transcription factors are an important, conserved family of regulators of cellular processes including metabolism, cell-cycle progression, apoptosis and…”
Get full text

The relationship between disease activity and UDCA response criteria in primary biliary cholangitis: A cohort study by Jones, David E.J., Wetten, Aaron, Barron-Millar, Ben, Ogle, Laura, Mells, George, Flack, Steven, Sandford, Richard, Kirby, John, Palmer, Jeremy, Brotherston, Sophie, Jopson, Laura, Brain, John, Smith, Graham R., Rushton, Steve, Jones, Rebecca, Rushbrook, Simon, Thorburn, Douglas, Ryder, Stephen D., Hirschfield, Gideon, Dyson, Jessica K.

“…Uncertainty exists about how best to identify primary biliary cholangitis (PBC) patients who would benefit from second-line therapy. Existing, purely clinical,…”
Get full text

Estimating ecological metrics for holistic conservation management in a biodiverse but information‐poor tropical region by Devenish, Christian, Nuñez Cortez, Elio, Buchanan, Graeme, Smith, Graham R., Marsden, Stuart J.

“…Conservation ecologists face the dual challenge of working with difficult‐to‐study species and providing ecological metrics that support conservation…”
Get full text

Simulation approaches to ion channel structure-function relationships by Tieleman, D P, Biggin, P C, Smith, G R, Sansom, M S

Get more information

Molecular Dynamics Simulations of the Bacterial Outer Membrane Protein FhuA: A Comparative Study of the Ferrichrome-Free and Bound States by Faraldo-Gómez, José D., Smith, Graham R., Sansom, Mark S.P.

“…FhuA is one of the more complex members of the superfamily of bacterial outer membrane proteins. Its primary function is to provide a binding site on the outer…”
Get full text

NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy by Kataura, Tetsushi, Otten, Elsje G, Rabanal‐Ruiz, Yoana, Adriaenssens, Elias, Urselli, Francesca, Scialo, Filippo, Fan, Lanyu, Smith, Graham R, Dawson, William M, Chen, Xingxiang, Yue, Wyatt W, Bronowska, Agnieszka K, Carroll, Bernadette, Martens, Sascha, Lazarou, Michael, Korolchuk, Viktor I

“…Mitophagy, the elimination of mitochondria via the autophagy‐lysosome pathway, is essential for the maintenance of cellular homeostasis. The best characterised…”
Get full text

Restored saltmarshes lack the topographic diversity found in natural habitat by Lawrence, Peter J., Smith, Graham R., Sullivan, Martin J.P., Mossman, Hannah L.

“…•Saltmarsh restored by managed realignment (MR) has fewer creeks than natural marsh.•MRs are topographically more like agricultural land than natural…”
Get full text

Mapping regulating ecosystem service deprivation in urban areas: A transferable high-spatial resolution uncertainty aware approach by Baker, Fraser, Smith, Graham R., Marsden, Stuart J., Cavan, Gina

“…•Maps of ecosystem services to demand at scale (100 m) of micro-scale benefit transfer.•Coldspot concept investigated to identify neighbourhood ecosystem…”
Get full text

The impact and process of a community-led intervention on reducing environmental inequalities related to physical activity and healthy eating - a pilot study by Davey, Rachel C, Hurst, Gemma L, Smith, Graham R, Grogan, Sarah C, Kurth, Judy

“…There is growing recognition that a sedentary lifestyle is being driven, at least in part, by environmental factors that affect individuals' physical activity…”
Get full text

Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2 by Paish, Hannah L., Kalson, Nicholas S., Smith, Graham R., del Carpio Pons, Alicia, Baldock, Thomas E., Smith, Nicholas, Swist-Szulik, Katarzyna, Weir, David J., Bardgett, Michelle, Deehan, David J., Mann, Derek A., Borthwick, Lee A.

“…Fibroblasts persist within fibrotic scar tissue and exhibit considerable phenotypic and functional plasticity. Herein, we hypothesized that scar-associated…”
Get full text