Search Results - "Smith, Grace C."

NAPS: Integrating pose estimation and tag-based tracking by Wolf, Scott W, Ruttenberg, Dee M, Knapp, Daniel Y, Webb, Andrew E, Traniello, Ian M, McKenzie-Smith, Grace C, Leheny, Sophie A, Shaevitz, Joshua W, Kocher, Sarah D

“…1. Significant advances in computational ethology have allowed the quantification of behaviour in unprecedented detail. Tracking animals in social groups,…”
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SLEAP: A deep learning system for multi-animal pose tracking by Pereira, Talmo D., Tabris, Nathaniel, Matsliah, Arie, Turner, David M., Li, Junyu, Ravindranath, Shruthi, Papadoyannis, Eleni S., Normand, Edna, Deutsch, David S., Wang, Z. Yan, McKenzie-Smith, Grace C., Mitelut, Catalin C., Castro, Marielisa Diez, D’Uva, John, Kislin, Mikhail, Sanes, Dan H., Kocher, Sarah D., Wang, Samuel S.-H., Falkner, Annegret L., Shaevitz, Joshua W., Murthy, Mala

“…The desire to understand how the brain generates and patterns behavior has driven rapid methodological innovation in tools to quantify natural animal behavior…”
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Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior by Brockway, Dakota F., Griffith, Keith R., Aloimonos, Chloe M., Clarity, Thomas T., Moyer, J. Brody, Smith, Grace C., Dao, Nigel C., Hossain, Md Shakhawat, Drew, Patrick J., Gordon, Joshua A., Kupferschmidt, David A., Crowley, Nicole A.

“…We sought to characterize the unique role of somatostatin (SST) in the prelimbic (PL) cortex in mice. We performed slice electrophysiology in pyramidal and…”
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Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline by Seemiller, Laurel R., Flores-Cuadra, Julio, Griffith, Keith R., Smith, Grace C., Crowley, Nicole A.

“…Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require…”
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Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila by Child, Myron Barber, Bateman, Jack R, Jahangiri, Amir, Reimer, Armando, Lammers, Nicholas C, Sabouni, Nica, Villamarin, Diego, McKenzie-Smith, Grace C, Johnson, Justine E, Jost, Daniel, Garcia, Hernan G

“…Three-dimensional eukaryotic genome organization provides the structural basis for gene regulation. In Drosophila melanogaster , genome folding is…”
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Isolation disrupts social interactions and destabilizes brain development in bumblebees by Wang, Z. Yan, McKenzie-Smith, Grace C., Liu, Weijie, Cho, Hyo Jin, Pereira, Talmo, Dhanerawala, Zahra, Shaevitz, Joshua W., Kocher, Sarah D.

“…Social isolation, particularly in early life, leads to deleterious physiological and behavioral outcomes. Here, we leverage new high-throughput tools to…”
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Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice by Smith, Grace C., Griffith, Keith R., Sicher, Avery R., Brockway, Dakota F., Proctor, Elizabeth A., Crowley, Nicole A.

“…Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of…”
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Adolescent binge drinking leads to long-lasting changes in cortical microcircuits in mice by Sicher, Avery R., Starnes, William D., Griffith, Keith R., Dao, Nigel C., Smith, Grace C., Brockway, Dakota F., Crowley, Nicole A.

“…Adolescent drug consumption has increased risks to the individual compared to consumption in adulthood, due to the likelihood of long-term and permanent…”
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Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice by Fleeman, Rebecca M., Snyder, Amanda M., Kuhn, Madison K., Chan, Dennis C., Smith, Grace C., Crowley, Nicole A., Arnold, Amy C., Proctor, Elizabeth A.

“…•APOE4 and APOE3 male mice do not differ in weight and adiposity gain with age.•APOE4 female mice experience attenuated increases in weight and adiposity with…”
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Publisher Correction: SLEAP: A deep learning system for multi-animal pose tracking by Pereira, Talmo D., Tabris, Nathaniel, Matsliah, Arie, Turner, David M., Li, Junyu, Ravindranath, Shruthi, Papadoyannis, Eleni S., Normand, Edna, Deutsch, David S., Wang, Z. Yan, McKenzie-Smith, Grace C., Mitelut, Catalin C., Castro, Marielisa Diez, D’Uva, John, Kislin, Mikhail, Sanes, Dan H., Kocher, Sarah D., Wang, Samuel S.-H., Falkner, Annegret L., Shaevitz, Joshua W., Murthy, Mala

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Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models by Sicher, Avery R., Liss, Andrea, Vozella, Valentina, Marsland, Paige, Seemiller, Laurel R., Springer, Matthew, Starnes, William D., Griffith, Keith R., Smith, Grace C., Astefanous, Amy, Deak, Terrence, Roberto, Marisa, Varodayan, Florence P., Crowley, Nicole A.

“…•Adolescent drinking-in-the-dark (DID) binge drinking does not increase adulthood consumption in a DID model or a two bottle choice model in male and female…”
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Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice by Smith, Grace C, Griffith, Keith R, Sicher, Avery R, Brockway, Dakota F, Proctor, Elizabeth A, Crowley, Nicole A

“…Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of…”
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Behavior at High Resolution by McKenzie-Smith, Grace C

“…The physics of animal behavior is at an exciting time where an explosion of new computational tools and techniques is giving us access to unprecedented amounts…”
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Capturing continuous, long timescale behavioral changes in $\textit{Drosophila melanogaster}$ postural data by McKenzie-Smith, Grace C, Wolf, Scott W, Ayroles, Julien F, Shaevitz, Joshua W

“…Animal behavior spans many timescales, from short, seconds-scale actions to circadian rhythms over many hours to life-long changes during aging. Most…”
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Studies of cervical caps: I. Vaginal lesions associated with use of the Vimule cap by Bernstein, G S, Kilzer, L H, Coulson, A H, Nakamura, R M, Smith, G C, Bernstein, R, Frezieres, R, Clark, V A, Coan, C

“…Prior to investigating the contraceptive efficacy of cervical caps, we undertook a preliminary study to evaluate potential side effects of these devices. Women…”
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