Search Results - "Smith, Gerald F"

Design and natural science research on information technology by March, Salvatore T., Smith, Gerald F.

“…Research in IT must address the design tasks faced by practitioners. Real problems must be properly conceptualized and represented, appropriate techniques for…”
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Idea-Generation Techniques: A Formulary of Active Ingredients by SMITH, GERALD F.

“…ABSTRACT The profusion of creativity techniques that have been proposed and used is based on a much smaller set of active ingredients, devices that promote…”
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The minimum significant ratio: a statistical parameter to characterize the reproducibility of potency estimates from concentration-response assays and estimation by replicate-experiment studies by Eastwood, Brian J, Farmen, Mark W, Iversen, Philip W, Craft, Trelia J, Smallwood, Jeffrey K, Garbison, Kim E, Delapp, Neil W, Smith, Gerald F

“…The authors show by illustration that procedures used to validate the reliability of single-concentration high-throughput screens such as the signal window and…”
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Assessing Business Student Thinking Skills by Smith, Gerald F.

“…The development of student thinking skills is a major goal of business education. As with other such goals, student outcomes assessment must be undertaken to…”
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Problem-Based Learning: Can it Improve Managerial Thinking? by Smith, Gerald F.

“…Problem-based learning (PBL), widely employed in medical schools, has much to offer management education as well. This article presents a comparative analysis…”
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Beyond Critical Thinking And Decision Making: Teaching Business Students How To Think by Smith, Gerald F.

“…Teaching students how to think is a universal goal of educational institutions. Business schools have addressed this goal by injecting critical thinking…”
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Towards a Heuristic Theory of Problem Structuring by Smith, Gerald F

“…Management science is concerned with understanding and improving action-oriented managerial thought. While it has addressed this concern through decision…”
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Structure-Activity Study of Tripeptide Thrombin Inhibitors Using .alpha.-Alkyl Amino Acids and Other Conformationally Constrained Amino Acid Substitutions by Shuman, Robert T, Rothenberger, Robert B, Campbell, Charles S, Smith, Gerald F, Gifford-Moore, Donetta S, Paschal, Jonathan W, Gesellchen, Paul D

“…In our continuing effort to design novel thrombin inhibitors, a series of conformationally constrained amino acids (e.g. alpha-alkyl, N-alkyl cyclic, etc.)…”
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Thinking skills: the question of generality by Smith, Gerald F

“…This paper examines the question of whether there are useful general thinking skills. It offers a working definition of 'thinking skill' and identifies ways in…”
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Anthranilamide inhibitors of factor Xa by Mendel, David, Marquart, Angela L., Joseph, Sajan, Waid, Philip, Yee, Ying K., Tebbe, Anne Louise, Ratz, Andrew M., Herron, David K., Goodson, Theodore, Masters, John J., Franciskovich, Jeffry B., Tinsley, Jennifer M., Wiley, Michael R., Weir, Leonard C., Kyle, Jeffrey A., Klimkowski, Valentine J., Smith, Gerald F., Towner, Richard D., Froelich, Larry L., Buben, John, Craft, Trelia J.

“…SAR about the B-ring of N 2-aroyl anthranilamide 3e is described. B-ring o-aminoalkylethers and B-ring p-amine probes of the S1′ and S4 sites, respectively,…”
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d-Phenylglycinol-derived non-covalent factor Xa inhibitors: Effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity by Klimkowski, Valentine J., Watson, Brian M., Wiley, Michael R., Liebeschuetz, John, Franciskovich, Jeffry B., Marimuthu, Jothirajah, Bastian, Jolie A., Sall, Daniel J., Smallwood, Jeffrey K., Chirgadze, Nikolay Y., Smith, Gerald F., Foster, Ronald S., Craft, Trelia, Sipes, Philip, Chastain, Marcia, Sheehan, Scott M.

“…Analogs to a series of d-phenylglycinamide-derived factor Xa inhibitors were discovered. It was found that the S4 amide linkage can be replaced with an ether…”
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Investigation of the terminal P4 domain in a series of d-phenylglycinamide-based factor Xa inhibitors by Franciskovich, Jeffry B., Masters, John J., Weber, Wayne W., Klimkowski, Valentine J., Chouinard, Michael, Sipes, Philip R., Johnson, Lea M., Snyder, David W., Chastain, Marcia K., Craft, Trelia J., Towner, Richard D., Gifford-Moore, Donetta S., Froelich, Larry L., Smallwood, Jeffrey K., Foster, Ronald S., Smith, Gerald F., Liebeschuetz, John W., Murray, Christopher W., Young, Stephen C.

“…Several P4 domain derivatives of the d-phenylglycinamide-based scaffold ( 2) were synthesized and evaluated for their ability to bind to the serine protease…”
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A four component coupling strategy for the synthesis of d-phenylglycinamide-derived non-covalent factor Xa inhibitors by Sheehan, Scott M., Masters, John J., Wiley, Michael R., Young, Stephen C., Liebeschuetz, John W., Jones, Stuart D., Murray, Christopher W., Franciskovich, Jeffrey B., Engel, David B., Weber, Wayne W., Marimuthu, Jothirajah, Kyle, Jeffrey A., Smallwood, Jeffrey K., Farmen, Mark W., Smith, Gerald F.

“…A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of…”
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N 2-Aroylanthranilamide Inhibitors of Human Factor Xa by Yee, Ying K, Tebbe, Anne Louise, Linebarger, Jared H, Beight, Douglas W, Craft, Trelia J, Gifford-Moore, Donetta, Goodson, Theodore, Herron, David K, Klimkowski, Valentine J, Kyle, Jeffrey A, Sawyer, J. Scott, Smith, Gerald F, Tinsley, Jennifer M, Towner, Richard D, Weir, Leonard, Wiley, Michael R

“…Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K ass = 0.81 × 106 L/mol) led to a series of human factor Xa (hfXa) inhibitors based on N…”
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Popkewitz, T.S., Franklin, B.M., & Pereyra, M.A. (Eds.). (2001 ). Cultural History and Education: Critical Essays on Knowledge and Schooling. New York, NY: Routledge Palmer, (softcover), 369 pages by Smith, Gerald F.

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Investigation of factor Xa inhibitors containing non-amidine S1 elements by Franciskovich, Jeffry B., Masters, John J., Tinsley, Jennifer M., Craft, Trelia J., Froelich, Larry L., Gifford-Moore, Donetta S., Klimkowski, Valentine J., Smallwood, Jeffrey K., Smith, Gerald F., Smith, Tommy, Towner, Richard R., Weir, Leonard C., Wiley, Michael R.

“…Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold were synthesized and evaluated for their ability to inhibit the human protease…”
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Defining Managerial Problems: A Framework for Prescriptive Theorizing by Smith, Gerald F

“…Reflective problem solving activity presumes the existence of a problem definition or representation, often the precursor of a formal model. Although problem…”
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Towards a comprehensive account of effective thinking by SMITH, Gerald F

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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives by Sall, Daniel J, Bailey, Dianna L, Bastian, Jolie A, Buben, John A, Chirgadze, Nickolay Y, Clemens-Smith, Amy C, Denney, Michael L, Fisher, Matthew J, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Johnson, Lea M, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Richett, Michael E, Smith, Gerald F, Snyder, David W, Takeuchi, Kumiko, Toth, John E, Zhang, Minsheng

“…A systematic investigation of the structure−activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent…”
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1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors by Takeuchi, Kumiko, Bastian, Jolie A, Gifford-Moore, Donetta S, Harper, Richard W, Miller, Shawn C, Mullaney, Jeffrey T, Sall, Daniel J, Smith, Gerald F, Zhang, Minsheng, Fisher, Matthew J

“…A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors. An indole…”
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