Search Results - "Smith, Ewan St John"

Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits by Parey, Elise, Fernandez-Aroca, Diego, Frost, Stephanie, Uribarren, Ainhoa, Park, Thomas J., Zöttl, Markus, St. John Smith, Ewan, Berthelot, Camille, Villar, Diego

“…Changes in gene regulation are thought to underlie most phenotypic differences between species. For subterranean rodents such as the naked mole-rat, proposed…”
Get full text

A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons by Perez-Sanchez, Jimena, Middleton, Steven J, Pattison, Luke A, Hilton, Helen, Ali Awadelkareem, Mosab, Zuberi, Sana R, Renke, Maria B, Hu, Huimin, Yang, Xun, Clark, Alex J, St John Smith, Ewan, Bennett, David L

“…Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a…”
Get more information

The Molecular Basis of Acid Insensitivity in the African Naked Mole-Rat by St. John Smith, Ewan, Omerbašić, Damir, Lechner, Stefan G., Anirudhan, Gireesh, Lapatsina, Liudmila, Lewin, Gary R.

“…Acid evokes pain by exciting nociceptors; the acid sensors are proton-gated ion channels that depolarize neurons. The naked mole-rat (Heterocephalus glaber) is…”
Get full text

Advances in understanding nociception and neuropathic pain by St John Smith, Ewan

“…Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a “detect and protect” mechanism. However, lesion or…”
Get full text

Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms by Smith, Ewan St. John, Park, Thomas J., Lewin, Gary R.

“…The naked mole-rat ( Heterocephalus glaber ) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and…”
Get full text

Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat by Schuhmacher, Laura-Nadine, Smith, Ewan St John

“…Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral…”
Get full text

The material properties of naked mole-rat hyaluronan by Kulaberoglu, Yavuz, Bhushan, Bharat, Hadi, Fazal, Chakrabarti, Sampurna, Khaled, Walid T., Rankin, Kenneth S., Smith, Ewan St. John, Frankel, Daniel

“…Hyaluronan (HA) is a key component of the extracellular matrix. Given the fundamental role of HA in the cancer resistance of the naked mole-rat (NMR), we…”
Get full text

Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control by Kulaberoglu, Yavuz, Lin, Kui, Holder, Maxine, Gai, Zhongchao, Gomez, Marta, Assefa Shifa, Belul, Mavis, Merdiye, Hoa, Lily, Sharif, Ahmad A. D., Lujan, Celia, Smith, Ewan St. John, Bjedov, Ivana, Tapon, Nicolas, Wu, Geng, Hergovich, Alexander

“…The Hippo tumor suppressor pathway is essential for development and tissue growth control, encompassing a core cassette consisting of the Hippo (MST1/2), Warts…”
Get full text

Single-cell RNAseq reveals seven classes of colonic sensory neuron by Hockley, James R F, Taylor, Toni S, Callejo, Gerard, Wilbrey, Anna L, Gutteridge, Alex, Bach, Karsten, Winchester, Wendy J, Bulmer, David C, McMurray, Gordon, Smith, Ewan St John

“…Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory…”
Get more information

Characterization of cutaneous and articular sensory neurons by da Silva Serra, Ines, Husson, Zoé, Bartlett, Jonathan D., Smith, Ewan St. John

“…Background A wide range of stimuli can activate sensory neurons and neurons innervating specific tissues often have distinct properties. Here, we used…”
Get full text

Role of Human Mesenchymal Stem Cells and Derived Extracellular Vesicles in Reducing Sensory Neuron Hyperexcitability and Pain Behaviors in Murine Osteoarthritis by Ai, Minji, Hotham, William E., Pattison, Luke A., Ma, Qingxi, Henson, Frances M.D., Smith, Ewan St. John

“…Objective Mesenchymal stem/stromal cells (MSCs) and MSC‐derived extracellular vesicles (MSC‐EVs) have been reported to alleviate pain in patients with knee…”
Get full text

Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice by Chakrabarti, Sampurna, Pattison, Luke A., Doleschall, Balint, Rickman, Rebecca H., Blake, Helen, Callejo, Gerard, Heppenstall, Paul A., Smith, Ewan St. John

“…Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee‐innervating dorsal root…”
Get full text

Mapping the neuroethological signatures of pain, analgesia, and recovery in mice by Bohic, Manon, Pattison, Luke A., Jhumka, Z. Anissa, Rossi, Heather, Thackray, Joshua K., Ricci, Matthew, Mossazghi, Nahom, Foster, William, Ogundare, Simon, Twomey, Colin R., Hilton, Helen, Arnold, Justin, Tischfield, Max A., Yttri, Eric A., St. John Smith, Ewan, Abdus-Saboor, Ishmail, Abraira, Victoria E.

“…Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting physiology, motor function, and motivation to engage in certain…”
Get full text

Neurobiology: Crowdsourcing CO2 to Conserve Brain Energy by St. John Smith, Ewan, Park, Thomas J.

“…Naked mole-rats are adapted to living in a low-oxygen and high-CO2 environment. Elevated environmental CO2 inhibits brain activity and has acted as a selection…”
Get full text

Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli by Taylor, Toni S., Konda, Parvesh, John, Sarah S., Bulmer, David C., Hockley, James R. F., Smith, Ewan St. John

“…Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent…”
Get full text

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology by Buffenstein, Rochelle, Amoroso, Vincent, Andziak, Blazej, Avdieiev, Stanislav, Azpurua, Jorge, Barker, Alison J., Bennett, Nigel C., Brieño‐Enríquez, Miguel A., Bronner, Gary N., Coen, Clive, Delaney, Martha A., Dengler‐Crish, Christine M., Edrey, Yael H., Faulkes, Chris G., Frankel, Daniel, Friedlander, Gerard, Gibney, Patrick A., Gorbunova, Vera, Hine, Christopher, Holmes, Melissa M., Jarvis, Jennifer U. M., Kawamura, Yoshimi, Kutsukake, Nobuyuki, Kenyon, Cynthia, Khaled, Walid T., Kikusui, Takefumi, Kissil, Joseph, Lagestee, Samantha, Larson, John, Lauer, Amanda, Lavrenchenko, Leonid A., Lee, Angela, Levitt, Jonathan B., Lewin, Gary R., Lewis Hardell, Kaitlyn N., Lin, TzuHua D., Mason, Matthew J., McCloskey, Dan, McMahon, Mary, Miura, Kyoko, Mogi, Kazutaka, Narayan, Vikram, O'Connor, Timothy P., Okanoya, Kazuo, O'Riain, M. Justin, Park, Thomas J., Place, Ned J., Podshivalova, Katie, Pamenter, Matthew E., Pyott, Sonja J., Reznick, Jane, Ruby, J. Graham, Salmon, Adam B., Santos‐Sacchi, Joseph, Sarko, Diana K., Seluanov, Andrei, Shepard, Alyssa, Smith, Megan, Storey, Kenneth B., Tian, Xiao, Vice, Emily N., Viltard, Mélanie, Watarai, Akiyuki, Wywial, Ewa, Yamakawa, Masanori, Zemlemerova, Elena D., Zions, Michael, Smith, Ewan St. John

“…ABSTRACT The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical…”
Get full text

Nociceptors: a phylogenetic view by Smith, Ewan St. John, Lewin, Gary R

“…The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to…”
Get full text

Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers by Schuhmacher, Laura-Nadine, Callejo, Gerard, Srivats, Shyam, Smith, Ewan St. John

“…Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are activated by extracellular protons and are involved in a wide…”
Get full text

Naked mole-rat cortical neurons are resistant to acid-induced cell death by Husson, Zoé, Smith, Ewan St John

“…Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal excitability…”
Get full text

Human visceral nociception: findings from translational studies in human tissue by Hockley, James R F, Smith, Ewan St John, Bulmer, David C

“…Peripheral sensitization of nociceptors during disease has long been recognized as a leading cause of inflammatory pain. However, a growing body of data…”
Get more information