Search Results - "Smith, Eric M."

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface by Lewis, Steven M, Wu, Xiufeng, Pustilnik, Anna, Sereno, Arlene, Huang, Flora, Rick, Heather L, Guntas, Gurkan, Leaver-Fay, Andrew, Smith, Eric M, Ho, Carolyn, Hansen-Estruch, Christophe, Chamberlain, Aaron K, Truhlar, Stephanie M, Conner, Elaine M, Atwell, Shane, Kuhlman, Brian, Demarest, Stephen J

“…Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody…”
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Dissecting the telomere–inner nuclear membrane interface formed in meiosis by Pendlebury, Devon F, Fujiwara, Yasuhiro, Tesmer, Valerie M, Smith, Eric M, Shibuya, Hiroki, Watanabe, Yoshinori, Nandakumar, Jayakrishnan

“…Structural and functional analyses of human TRF1 in complex with meiosis-specific protein TERB1 reveal the basis for telomere tethering to the inner nuclear…”
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Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma by Movassagh, Hesam, Prunicki, Mary, Kaushik, Abhinav, Zhou, Xiaoying, Dunham, Diane, Smith, Eric M., He, Ziyuan, Aleman Muench, German R., Shi, Minyi, Weimer, Annika K., Cao, Shu, Andorf, Sandra, Feizi, Amir, Snyder, Michael P., Soroosh, Pejman, Mellins, Elizabeth D., Nadeau, Kari C.

“…Background The impact of exposure to air pollutants, such as fine particulate matter (PM), on the immune system and its consequences on pediatric asthma, are…”
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Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy by Clark, Justin T, Clark, Meredith R, Shelke, Namdev B, Johnson, Todd J, Smith, Eric M, Andreasen, Andrew K, Nebeker, Joel S, Fabian, Judit, Friend, David R, Kiser, Patrick F

“…The HIV/AIDS pandemic and its impact on women prompt the investigation of prevention strategies to interrupt sexual transmission of HIV. Long-acting drug…”
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Structural biology of telomeres and telomerase by Smith, Eric M., Pendlebury, Devon F., Nandakumar, Jayakrishnan

“…Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes…”
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A nondepleting anti-CD19 antibody impairs B cell function and inhibits autoimmune diseases by Boyles, Jeffrey S, Sadowski, Dorota, Potter, Scott, Vukojicic, Aleksandra, Parker, James, Chang, William Y, Ma, Yanfei L, Chambers, Mark G, Nelson, James, Barmettler, Barbra, Smith, Eric M, Kersjes, Kara, Himes, Evan R, Lin, Chaohua, Lucchesi, Jonathan, Brahmbhatt, Jaladhi, Sina, Ramtin, Martin, Jennifer A, Maestri, Evan, Wiethoff, Christopher M, Dyas, Gregory L, Linnik, Matthew D, Na, Songqing, Witcher, Derrick R, Budelsky, Alison, Rubtsova, Kira

“…B cells contribute to multiple aspects of autoimmune disorders, and B cell-targeting therapies, including B cell depletion, have been proven to be efficacious…”
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Basic residues at the C-gate of DNA gyrase are involved in DNA supercoiling by Smith, Eric M., Mondragón, Alfonso

“…DNA gyrase is a type II topoisomerase that is responsible for maintaining the topological state of bacterial and some archaeal genomes. It uses an…”
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Scale invariance in early embryonic development by Nikolić, Miloš, Antonetti, Victoria, Liu, Feng, Muhaxheri, Gentian, Petkova, Mariela D., Scheeler, Martin, Smith, Eric M., Bialek, William, Gregor, Thomas

“…The expression of a few key genes determines the body plan of the fruit fly. We show that the spatial expression patterns for several of these genes scale…”
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Structural and functional consequences of a disease mutation in the telomere protein TPP1 by Bisht, Kamlesh, Smith, Eric M., Tesmer, Valerie M., Nandakumar, Jayakrishnan

“…Telomerase replicates chromosome ends to facilitate continued cell division. Mutations that compromise telomerase function result in stem cell failure…”
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Structures of an active type III-A CRISPR effector complex by Smith, Eric M., Ferrell, Sé, Tokars, Valerie L., Mondragón, Alfonso

“…Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) provide many prokaryotes with an adaptive immune…”
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Combining conservation and species-specific differences to determine how human telomerase binds telomeres by Tesmer, Valerie M., Smith, Eric M., Danciu, Oana, Padmanaban, Shilpa, Nandakumar, Jayakrishnan

“…Telomerase catalyzes telomeric DNA synthesis at chromosome ends to allow for continued cell division. The telomeric protein TPP1 is essential for enhancing the…”
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Associations of Restraint and Seclusion With Race and Ethnicity on an Adolescent Inpatient Psychiatry Service by Daniels, Teresa E., Victor, Colleen, Smith, Eric M., Belgrave, Christa, Robinson, Erica, Wolff, Jennifer C., Hunt, Jeffrey, Brannan, Elizabeth H.

“…There is limited work examining the association of race and ethnicity with restraint and seclusion (R/S) in pediatric inpatient psychiatric units. The present…”
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Non–immunoglobulin E-mediated allergy associated with Pfizer-BioNTech coronavirus disease 2019 vaccine excipient polyethylene glycol by Jiang, Shirley Y., Smith, Eric M., Vo, Victor, Akdis, Cezmi, Nadeau, Kari C.

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Adverse effects of air pollution‐derived fine particulate matter on cardiovascular homeostasis and disease by Bae, Hye Ryeong, Chandy, Mark, Aguilera, Juan, Smith, Eric M., Nadeau, Kari C., Wu, Joseph C., Paik, David T.

“…Air pollution is a rapidly growing major health concern around the world. Atmospheric particulate matter that has a diameter of less than 2.5 µm (PM2.5) refers…”
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Ocular mass in the anterior chamber of a 9-year-old male Golden Retriever by Medlin, Phil S., Kovach-Zukin, Judith, Fiddes, Kelsey R., Smith, Eric M., LaDouceur, Elise E. B.

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Associations of early life stress with leptin and ghrelin in healthy young adults by Daniels, Teresa E., Mathis, Karen Jennings, Gobin, Asi Polly, Lewis-de los Angeles, William W., Smith, Eric M., Chanthrakumar, Pranavan, de la Monte, Suzanne, Tyrka, Audrey R.

“…Childhood adversity is a major risk factor for cardiometabolic health problems. Stress-related changes in diet suggest a role for endocrine factors that…”
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IL-10 as a mediator in the HPA axis and brain by Smith, Eric M, Cadet, Patrick, Stefano, George B, Opp, Mark R, Hughes, Thomas K

“…Certain functional interactions between the nervous, endocrine, and immune systems are mediated by cytokines. The pro-inflammatory cytokines, interleukin-1…”
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Conceptual development of the immune system as a sixth sense by Blalock, J. Edwin, Smith, Eric M

“…Abstract Understanding how and why the immune and nervous systems communicate in a bidirectional pathway has been fundamental to the development of the…”
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Morphology-Dependent Trap Formation in Bulk Heterojunction Photodiodes by Shao, Guozheng, Rayermann, Glennis E, Smith, Eric M, Ginger, David S

“…We show that local structural variation affects the rate of aging in nanostructured polymer solar cells by comparing time-resolved electrostatic force…”
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Neuropeptides as signal molecules in common with leukocytes and the hypothalamic–pituitary–adrenal axis by Smith, Eric M

“…Abstract There exists a bidirectional regulatory circuit between the nervous and immune systems. This regulation has been shown to be mediated in part through…”
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