Search Results - "Smith, Eric L."

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy by Khalil, Danny N., Smith, Eric L., Brentjens, Renier J., Wolchok, Jedd D.

“…Key Points Cancer immunotherapies have the potential to generate robust antitumour responses; this can be achieved through several methods, such as modulatory…”
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unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases by Smith, Eric L, Schuchman, Edward H

“…Acid sphingomyelinase (ASM; E.C. 3.1.4.12) is best known for its involvement in the lysosomal storage disorder Niemann-Pick disease (NPD). Through studies that…”
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Barbed Versus Traditional Sutures: Closure Time, Cost, and Wound Related Outcomes in Total Joint Arthroplasty by Smith, Eric L., MD, DiSegna, Steven T., MS, Shukla, Pinak Y., MD, Matzkin, Elizabeth G., MD

“…Abstract The purpose of this study was to compare barbed sutures to traditional sutures in three domains: time, cost, and wound related outcomes in total knee…”
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Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies by Davila, Marco L., Bouhassira, Diana C. G., Park, Jae H., Curran, Kevin J., Smith, Eric L., Pegram, Hollie J., Brentjens, Renier

“…The genetic modification of autologous T cells with chimeric antigen receptors (CARs) represents a breakthrough for gene engineering as a cancer therapy for…”
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Predictive Risk Factors for 30-day Readmissions Following Primary Total Joint Arthroplasty and Modification of Patient Management by Tayne, Samantha, BA, Merrill, Christian A., BS, Smith, Eric L., MD, Mackey, William C., MD

“…Abstract The Centers for Medicare and Medicaid have begun to publically publish statistics on readmissions following primary total hip (THA) and total knee…”
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National Trends in Primary Total Hip Arthroplasty in Extremely Young Patients: A Focus on Bearing Surface Usage from 2009 to 2012 by Rajaee, Sean S., M.D., M.S, Theriault, Raminta V., M.S, Pevear, Mary E., B.A, Smith, Eric L., M.D

“…Background The ideal bearing surface for primary total hip arthroplasty (THA) in young patients remains a debate. Data on recent national trends is lacking…”
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CD19-directed chimeric antigen receptor T cell therapy in Waldenström macroglobulinemia: a preclinical model and initial clinical experience by Palomba, M Lia, Qualls, David, Monette, Sebastien, Sethi, Shenon, Dogan, Ahmet, Roshal, Mikhail, Senechal, Brigitte, Wang, Xiuyan, Rivière, Isabelle, Sadelain, Michel, Brentjens, Renier J, Park, Jae H, Smith, Eric L

“…BackgroundWaldenström macroglobulinemia (WM) is an incurable disease and, while treatable, can develop resistance to available therapies and be fatal. Chimeric…”
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Total Joint Arthroplasty in Patients Taking Methadone or Buprenorphine/Naloxone Preoperatively for Prior Heroin Addiction: A Prospective Matched Cohort Study by Hansen, Lauren E., MD, Stone, Genevra L., MD, Matson, Christopher A., BS, MS, Tybor, David J., PhD, MPH, Pevear, Mary E., BA, Smith, Eric L., MD

“…Abstract Background Preoperative narcotic use has been associated with poor outcomes after total joint arthroplasty (TJA). The purpose of this study is to…”
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Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques by KAUFMAN, Daniel, BANERJI, Mary Ann, SHORMAN, Igor, SMITH, Eric L. P, COPLAN, Jeremy D, ROSENBLUM, Leonard A, KRAL, John G

“…Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques Daniel Kaufman 1 2 , Mary Ann Banerji 2 3 , Igor Shorman 1…”
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Maternal hypothalamic-pituitary-adrenal axis response to foraging uncertainty: A model of individual vs. social allostasis and the "Superorganism Hypothesis" by Coplan, Jeremy D, Gupta, Nishant K, Karim, Asif, Rozenboym, Anna, Smith, Eric L P, Kral, John G, Rosenblum, Leonard A

“…Food insecurity is a major global contributor to developmental origins of adult disease. The allostatic load of maternal food uncertainty from variable…”
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Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates by Jackowski, Andrea, Perera, Tarique D, Abdallah, Chadi G, Garrido, Griselda, Tang, Cheuk Y, Martinez, Jose, Mathew, Sanjay J, Gorman, Jack M, Rosenblum, Leonard A, Smith, Eric L.P, Dwork, Andrew J, Shungu, Dikoma C, Kaffman, Arie, Gelernter, Joel, Coplan, Jeremy D, Kaufman, Joan

“…Abstract Male bonnet monkeys ( Macaca radiata ) were subjected to the variable foraging demand (VFD) early stress paradigm as infants, MRI scans were completed…”
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Comparing Inpatient Complication Rates between Octogenarians and Nonagenarians Following Primary and Revision Total Hip Arthroplasty in a Nationally Representative Sample 2010-2014 by Dugdale, Evan M, Tybor, David, Kain, Michael, Smith, Eric L

“…We compared inpatient postoperative complication rates between octogenarians and nonagenarians undergoing primary and revision total hip arthroplasty (THA). We…”
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Modular Knee Arthrodesis as Definitive Treatment for Periprosthetic Infection, Bone Loss, and Failure of the Extensor Mechanism After Total Knee Arthroplasty by Coden, Gloria, Bartashevskyy, Maksym, Berliner, Zachary, Niu, Ruijia, Freccero, David, Bono, James, Abdeen, Ayesha, Smith, Eric L.

“…Periprosthetic joint infection (PJI) after total knee arthroplasty (TKA) can result in bone and soft-tissue loss, leg length discrepancies, and dysfunctional…”
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Harnessing the immune system for cancer therapy by Smith, Eric L, Zamarin, Dmitriy, Lesokhin, Alexander M

“…PURPOSE OF REVIEWOver the last 18 months, substantial progress has been made in demonstrating the clinical efficacy of harnessing the immune system to treat a…”
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The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma by Shah, Nina, Aiello, Jack, Avigan, David E, Berdeja, Jesus G, Borrello, Ivan M, Chari, Ajai, Cohen, Adam D, Ganapathi, Karthik, Gray, Lissa, Green, Damian, Krishnan, Amrita, Lin, Yi, Manasanch, Elisabet, Munshi, Nikhil C, Nooka, Ajay K, Rapoport, Aaron P, Smith, Eric L, Vij, Ravi, Dhodapkar, Madhav

“…Outcomes in multiple myeloma (MM) have improved dramatically in the last two decades with the advent of novel therapies including immunomodulatory agents…”
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Ethnic Barriers to Utilization of Total Joint Arthroplasty Among Chinese Immigrants in the United States by Alley, Maxwell C., BA, Mason, Andrew S., MS, Tybor, David, PhD, Pevear, Mary E., BA, Baratz, Michael D, Smith, Eric L., M.D

“…Abstract Background Previous studies have documented disparities in total joint arthroplasty (TJA) utilization among African American and Hispanic patients,…”
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Total Joint Arthroplasty Surgery: Does Day of Surgery Matter? by Muppavarapu, Raghuveer C., MD, Chaurasia, Avinash R., BS, Schwarzkopf, Ran, MD, Matzkin, Elizabeth G., MD, Cassidy, Charles C., MD, Smith, Eric L., MD

“…Abstract Length of stay (LOS) after total joint arthroplasty (TJA) impacts the expense to the hospital. Our purpose was to evaluate the impact that day of…”
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Depletion of high-content CD14+ cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing by Wang, Xiuyan, Borquez-Ojeda, Oriana, Stefanski, Jolanta, Du, Fang, Qu, Jinrong, Chaudhari, Jagrutiben, Thummar, Keyur, Zhu, Mingzhu, Shen, Ling-bo, Hall, Melanie, Gautam, Paridhi, Wang, Yongzeng, Sénéchal, Brigitte, Sikder, Devanjan, Adusumilli, Prasad S., Brentjens, Renier J., Curran, Kevin, Geyer, Mark B., Mailankhody, Sham, O’Cearbhaill, Roisin, Park, Jae H., Sauter, Craig, Slovin, Susan, Smith, Eric L., Rivière, Isabelle

“…With the US Food and Drug Administration (FDA) approval of four CD19- and one BCMA-targeted chimeric antigen receptor (CAR) therapy for B cell malignancies,…”
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Total Knee Arthroplasty Hospital Costs by Time-Driven Activity-Based Costing: Robotic vs Conventional by Fang, Christopher J., Mazzocco, John C., Sun, Daniel C., Shaker, Jonathan M., Talmo, Carl T., Mattingly, David A., Smith, Eric L.

“…Total knee arthroplasty (TKA) represents a major national health expenditure. The last decade has seen a surge in robotic-assisted TKA (roTKA); however,…”
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Episode-of-Care Costs for Revision Total Joint Arthroplasties by Decadal Age Groups by Fang, Christopher, Pagani, Nicholas, Gordon, Matthew, Talmo, Carl T, Mattingly, David A, Smith, Eric L

“…The demand for revision total joint arthroplasties (rTJAs) is expected to increase as the age of the population continues to rise. Accurate cost data regarding…”
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