Search Results - "Smith, Emilie D"

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents by Huang, Kenneth H, Veal, James M, Fadden, R. Patrick, Rice, John W, Eaves, Jeron, Strachan, Jon-Paul, Barabasz, Amy F, Foley, Briana E, Barta, Thomas E, Ma, Wei, Silinski, Melanie A, Hu, Mei, Partridge, Jeffrey M, Scott, Anisa, DuBois, Laura G, Freed, Tiffany, Steed, Paul M, Ommen, Andy J, Smith, Emilie D, Hughes, Philip F, Woodward, Angela R, Hanson, Gunnar J, McCall, W. Stephen, Markworth, Christopher J, Hinkley, Lindsay, Jenks, Matthew, Geng, Lifeng, Lewis, Meredith, Otto, James, Pronk, Bert, Verleysen, Katleen, Hall, Steven E

“…A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library…”
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Synthesis of C-4 Substituted Nicotine Derivatives via an N-Acylpyridinium Salt of (S)-Nicotine by Comins, Daniel L, King, Laura S, Smith, Emilie D, Février, Florence C

“…A variety of novel nicotine derivatives were prepared from (S)-nicotine via a two-step sequence. Addition of a cuprate reagent to an N-acylpyridinium salt of…”
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Regioselective C-2 and C-6 Substitution of (S)-Nicotine and Nicotine Derivatives by Février, Florence C, Smith, Emilie D, Comins, Daniel L

“…Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields…”
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Synthesis of Nicotine Derivatives via Reductive Disilylation of (S)-Nicotine by Smith, Emilie D, Février, Florence C, Comins, Daniel L

“…A variety of novel nicotine derivatives were prepared via reductive disilylation of (S)-nicotine. Treatment of nicotine with lithium powder and…”
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Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations by Cloudsdale, Ian S., Dickson, John K., Barta, Thomas E., Grella, Brian S., Smith, Emilie D., Kulp, John L., Guarnieri, Frank, Kulp, John L.

“…[Display omitted] We have applied simulated annealing of chemical potential (SACP) to a diverse set of ∼150 very small molecules to provide insights into new…”
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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90 by Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.

“…Compound affinity to Hsp90 in Kd and cellular activities in IC50. A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds,…”
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A six-step synthesis of ( S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from ( S)-nicotine by Comins, Daniel L., Smith, Emilie D.

“…The anti-Parkinson’s agent SIB-1508Y was prepared in six steps from ( S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at…”
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Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90 by Fadden, Patrick, Huang, Kenneth H., Veal, James M., Steed, Paul M., Barabasz, Amy F., Foley, Briana, Hu, Mei, Partridge, Jeffrey M., Rice, John, Scott, Anisa, Dubois, Laura G., Freed, Tiffany A., Silinski, Melanie A. Rehder, Barta, Thomas E., Hughes, Philip F., Ommen, Andy, Ma, Wei, Smith, Emilie D., Spangenberg, Angela Woodward, Eaves, Jeron, Hanson, Gunnar J., Hinkley, Lindsay, Jenks, Matthew, Lewis, Meredith, Otto, James, Pronk, Gijsbertus J., Verleysen, Katleen, Haystead, Timothy A., Hall, Steven E.

“…A chemoproteomics-based drug discovery strategy is presented that utilizes a highly parallel screening platform, encompassing more than 1000 targets, with a…”
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A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay by SMITH, Emilie D, ARIANE VINSON, N, DESONG ZHONG, BERRANG, Bertold D, CATANZARO, Jennifer L, THOMAS, James B, NAVARRO, Hernan A, GILMOUR, Brian P, DESCHAMPS, Jeffrey, CARROLL, F. Ivy

“…A new chiral synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (2,…”
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A new synthesis of the ORL-1 antagonist 1-[(3 R,4 R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2 H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay by Smith, Emilie D., Ariane Vinson, N., Zhong, Desong, Berrang, Bertold D., Catanzaro, Jennifer L., Thomas, James B., Navarro, Hernán A., Gilmour, Brian P., Deschamps, Jeffrey, Carroll, F. Ivy

“…A new chiral synthesis of the ORL-1 antagonist J-113397 was developed. Its in vitro efficacy was determined using an ORL-1 calcium mobilization assay. A new…”
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