Search Results - "Smith, Emil R"

Synthesis, Properties, and Pharmacokinetic Studies of N2-Phenylguanine Derivatives as Inhibitors of Herpes Simplex Virus Thymidine Kinases by Xu, Hongyan, Maga, Giovanni, Focher, Federico, Smith, Emil R, Spadari, Silvio, Gambino, Joseph, Wright, George E

“…Two series of selective inhibitors of herpes simplex virus types 1 and 2 (HSV1,2) thymidine kinases (TK) have been developed as potential treatment of…”
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The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphine by Chen, J C, Smith, E R, Cahill, M, Cohen, R, Fishman, J B

“…The ability of morphine, fentanyl, butorphanol, nalbuphine, and dezocine to compete with radiolabeled ligands for binding at the mu1, mu2, kappa1, and delta…”
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Stereoselectivity of tocainide pharmacodynamics in vivo and in vitro by Block, A J, Merrill, D, Smith, E R

“…Racemic tocainide [R,S-T], which is used in the treatment of ventricular arrhythmias, consists of an R(-)-enantiomer [R-T] and an S(+)-enantiomer [S-T]. The…”
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Investigation of reports of sexual dysfunction among male chemical workers manufacturing stilbene derivatives by Quinn, M M, Wegman, D H, Greaves, I A, Hammond, S K, Ellenbecker, M J, Spark, R F, Smith, E R

“…A Health Hazard Evaluation was conducted by the National Institute for Occupational Safety and Health in an area of a large chemical plant that manufactured…”
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New antiarrhythmic agents. 1. Primary .alpha.-amino anilides by Byrnes, Eugene W, McMaster, Paul D, Smith, Emil R, Blair, Murray R, Boyes, R. Nichol, Duce, Benjamin R, Feldman, Hal S, Kronberg, George H, Takman, Bertil H, Tenthorey, Paul A

“…Thirty-two alpha-amino anilides with various substituents in the aromatic ring and in the alpha position are described. Their abilities to protect mice against…”
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Renomedullary Vasodepressor Substance, Medullin: Isolation, Chemical Characterization and Physiological Properties by Lee, James B, Covino, Benjamin G, Takman, Bertil H, Smith, Emil R

“…The chemical and physiological properties of renomedullary depressor substances were investigated utilizing the normotensive, vagotomized, pentolinium-treated…”
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The single--and repeated--dose toxicity of dimethyl sulfoxide by Smith, E R, Hadidian, Z, Mason, M M

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New antiarrhythmic agents. 4. 1'-(aminoalkyl)-1,2,3,4-tetrahydronaphthalene-1-spiro-3'-pyrrolidine-2',5'-dione derivatives by Tenthorey, Paul A, Ronfeld, Robert A, Feldman, Hal S, Sandberg, Rune V, McMaster, Paul D, Smith, Emil R

“…A series of 33 1'-(Aminoalkyl)-1,2,3,4-tetrahydronaphthalene-1-spiro-3'-pyrrolidine-2',5'-dione derivatives was tested for antiarrhythmic and toxic effects in…”
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Antiarrhythmic effects in dogs of lidocaine administered orally and intravenously by Smith, E R, Duce, B R, Boyes, R N

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Serial Intravenous Doses of Dezocine, Morphine, and Nalbuphine in the Management of Postoperative Pain for Outpatients by Cohen, Robert I., Edwards, W. Thomas, Kezer, Edward A., Ferrari, Dudley A., Liland, Astrid E., Smith, Emil R.

“…Adult patients who had arthroscopic surgery under general anesthesia and requested postoperative pain relief were randomized to receive treatment in a…”
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Single- and multiple-dose pharmacokinetics of dezocine in patients with acute or chronic pain by Wilson, J M, Cohen, R I, Kezer, E A, Schange, S J, Smith, E R

“…The pharmacokinetic properties of dezocine were examined in 15 patients with acute or chronic pain. In 3 groups of 5 patients each, serum levels were…”
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Uterotropic action in rats of amsonic acid and three of its synthetic precursors by Smith, E R, Quinn, M M

“…Prompted by reports of sexual impotence among chemical factory workers exposed to amsonic acid (4,4'-diaminostilbene-2,2'-disulfonic acid; CAS 81-11-8) and its…”
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Secretion of bromide by the canine prostate by Smith, E R, Ilievski, V

“…Four dogs with surgically produced prostatic fistulas were given single oral doses of 1.13 gm of sodium bromide daily for five consecutive days. Two days later…”
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Biological activity and therapeutic potential of homologs of an Ii peptide which regulates antigenic peptide binding to cell surface MHC class II molecules by Adams, S, Albericio, F, Alsina, J, Smith, E R, Humphreys, R E

“…An invariant chain peptide (murine Ii76-92; Ii-Key) is known to produce a 10 to 50 times baseline enhancement of the presentation of specific antigenic…”
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The uptake and secretion of 3-methylcholanthrene by the prostate glands of the rat and dog by Smith, E R, Hagopian, M

“…In anesthetized rats in which prostatic fluid was collected over a 2-hour interval from 24 to 26 hours after a single ip dose of 5 mg…”
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The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine by Smith, E R, Duce, B R

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The stimulation of canine prostatic secretion by parasympathomimetic agents by Smith, E R

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The secretion of electrolytes by the pilocarpine-stimulated canine prostate gland by Smith, E R

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Efficacy of amoscanate against experimental schistosomal infections in monkeys by Crawford, K A, Asch, H L, Bruce, J I, Bueding, E, Smith, E R

“…The antischistosomal activity of oral doses of amoscanate (4-isothiocyanato-4'-nitrodiphenylamine) was determined in infected Cebus apella (capuchin monkeys)…”
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The stimulation of canine prostatic secretion by sympathomimetic amines by Smith, E R

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