Search Results - "Smith, Edwin R"

Born to run: control of transcription elongation by RNA polymerase II by Chen, Fei Xavier, Smith, Edwin R., Shilatifard, Ali

“…The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an integral part of the implementation of gene expression programmes during…”
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The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers by Hu, Deqing, Gao, Xin, Morgan, Marc A., Herz, Hans-Martin, Smith, Edwin R., Shilatifard, Ali

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PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II by Chen, Fei Xavier, Woodfin, Ashley R., Gardini, Alessandro, Rickels, Ryan A., Marshall, Stacy A., Smith, Edwin R., Shiekhattar, Ramin, Shilatifard, Ali

“…The control of promoter-proximal pausing and the release of RNA polymerase II (Pol II) is a widely used mechanism for regulating gene expression in metazoans,…”
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AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia by Lin, Chengqi, Smith, Edwin R., Takahashi, Hidehisa, Lai, Ka Chun, Martin-Brown, Skylar, Florens, Laurence, Washburn, Michael P., Conaway, Joan W., Conaway, Ronald C., Shilatifard, Ali

“…Chromosomal translocations involving the MLL gene are associated with infant acute lymphoblastic and mixed lineage leukemia. There are a large number of…”
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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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Zic2 Is an Enhancer-Binding Factor Required for Embryonic Stem Cell Specification by Luo, Zhuojuan, Gao, Xin, Lin, Chengqi, Smith, Edwin R., Marshall, Stacy A., Swanson, Selene K., Florens, Laurence, Washburn, Michael P., Shilatifard, Ali

“…The Zinc-finger protein of the cerebellum 2 (Zic2) is one of the vertebrate homologs of the Drosophila pair-rule gene odd-paired (opa). Our molecular and…”
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy by Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali

“…The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells by Hu, Deqing, Garruss, Alexander S, Gao, Xin, Morgan, Marc A, Cook, Malcolm, Smith, Edwin R, Shilatifard, Ali

“…Embryonic stem cells (ESCs) possess a unique chromatin landscape in which 'bivalent' domains of trimethylated histone H3 Lys4 (H3K4me3) and Lys27 (H3K27me3)…”
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Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors by Takahashi, Hidehisa, Parmely, Tari J., Sato, Shigeo, Tomomori-Sato, Chieri, Banks, Charles A.S., Kong, Stephanie E., Szutorisz, Henrietta, Swanson, Selene K., Martin-Brown, Skylar, Washburn, Michael P., Florens, Laurence, Seidel, Chris W., Lin, Chengqi, Smith, Edwin R., Shilatifard, Ali, Conaway, Ronald C., Conaway, Joan W.

“…Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of paused polymerase into productive elongation has emerged as a major…”
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An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters by Blackwell, Brett R, Ankley, Gerald T, Corsi, Steven R, DeCicco, Laura A, Houck, Keith A, Judson, Richard S, Li, Shibin, Martin, Matthew T, Murphy, Elizabeth, Schroeder, Anthony L, Smith, Edwin R, Swintek, Joe, Villeneuve, Daniel L

“…Current environmental monitoring approaches focus primarily on chemical occurrence. However, based on concentration alone, it can be difficult to identify…”
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PAF1 regulation of promoter-proximal pause release via enhancer activation by Chen, Fei Xavier, Xie, Peng, Collings, Clayton K., Cao, Kaixiang, Aoi, Yuki, Marshall, Stacy A., Rendleman, Emily J., Ugarenko, Michal, Ozark, Patrick A., Zhang, Anda, Shiekhattar, Ramin, Smith, Edwin R., Zhang, Michael Q., Shilatifard, Ali

“…Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal pausing and its release. Previously,we showed that Pol II–associated…”
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Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II by Wang, Pengfei, Lin, Chengqi, Smith, Edwin R., Guo, Hong, Sanderson, Brian W., Wu, Min, Gogol, Madelaine, Alexander, Tara, Seidel, Christopher, Wiedemann, Leanne M., Ge, Kai, Krumlauf, Robb, Shilatifard, Ali

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The COMPASS Family of H3K4 Methylases in Drosophila by Mohan, Man, Herz, Hans-Martin, Smith, Edwin R., Zhang, Ying, Jackson, Jessica, Washburn, Michael P., Florens, Laurence, Eissenberg, Joel C., Shilatifard, Ali

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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia by Liang, Kaiwei, Volk, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali

“…Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite…”
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Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC) by Lin, Chengqi, Garrett, Alexander S, De Kumar, Bony, Smith, Edwin R, Gogol, Madelaine, Seidel, Christopher, Krumlauf, Robb, Shilatifard, Ali

“…Transcriptional regulation of developmentally controlled genes is at the heart of differentiation and organogenesis. In this study, we performed global genomic…”
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The Little Elongation Complex Functions at Initiation and Elongation Phases of snRNA Gene Transcription by Hu, Deqing, Smith, Edwin R., Garruss, Alexander S., Mohaghegh, Nima, Varberg, Joseph M., Lin, Chengqi, Jackson, Jessica, Gao, Xin, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Eissenberg, Joel C., Shilatifard, Ali

“…The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their…”
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The Little Elongation Complex Regulates Small Nuclear RNA Transcription by Smith, Edwin R., Lin, Chengqi, Garrett, Alexander S., Thornton, Janet, Mohaghegh, Nima, Hu, Deqing, Jackson, Jessica, Saraf, Anita, Swanson, Selene K., Seidel, Christopher, Florens, Laurence, Washburn, Michael P., Eissenberg, Joel C., Shilatifard, Ali

“…Eleven-nineteen lysine-rich leukemia (ELL) participates in the super elongation complex (SEC) with the RNA polymerase II (Pol II) CTD kinase P-TEFb. SEC is a…”
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Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity by Luo, Zhuojuan, Lin, Chengqi, Woodfin, Ashley R, Bartom, Elizabeth T, Gao, Xin, Smith, Edwin R, Shilatifard, Ali

“…Genomic imprinting is a critical developmental process characteristic of parent of origin-specific gene expression. It is well accepted that differentially…”
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