Search Results - "Smith, Dawn G"

Glyoxalase I Is Critical for Human Retinal Capillary Pericyte Survival under Hyperglycemic Conditions by Miller, Antonia G., Smith, Dawn G., Bhat, Manjunatha, Nagaraj, Ram H.

“…Retinal capillary pericytes undergo premature death, possibly by apoptosis, during the early stages of diabetic retinopathy. The α-oxoaldehyde, methylglyoxal…”
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AGEs in human lens capsule promote the TGFβ2‐mediated EMT of lens epithelial cells: implications for age‐associated fibrosis by Raghavan, Cibin T., Smuda, Mareen, Smith, Andrew J. O., Howell, Scott, Smith, Dawn G., Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A., Wormstone, Ian Michael, Nagaraj, Ram H.

“…Summary Proteins in basement membrane (BM) are long‐lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is…”
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Effect of Dicarbonyl Modification of Fibronectin on Retinal Capillary Pericytes by Liu, BingFen, Bhat, Manjunatha, Padival, Anoop K, Smith, Dawn G, Nagaraj, Ram H

“…To determine effects of alpha-dicarbonyl modification of an extracellular matrix protein on retinal capillary pericyte attachment and viability. Primary…”
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Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration by Lindstrom, Sarah I., Sigurdardottir, Sigrun, Zapadka, Thomas E., Tang, Jie, Liu, Haitao, Taylor, Brooklyn E., Smith, Dawn G., Lee, Chieh A., DeAngelis, John, Kern, Timothy S., Taylor, Patricia R.

“…Diabetes leads to progressive complications such as diabetic retinopathy, which is the leading cause of blindness within the working-age population worldwide…”
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The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice by Nahomi, Rooban B, Sampathkumar, Sruthi, Myers, Angela M, Elghazi, Lynda, Smith, Dawn G, Tang, Jie, Lee, C Allen, Kern, Timothy S, Nagaraj, Ram H, Fort, Patrice E

“…Loss of retinal capillary endothelial cells and pericytes through apoptosis is an early event in diabetic retinopathy (DR). Inflammatory pathways play a role…”
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Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells by Xi, Xia, Gao, Ling, Hatala, Denise A., Smith, Dawn G., Codispoti, Maria C., Gong, Bendi, Kern, Timothy S., Zhang, Jin-Zhong

“…Hyperglycemia induces apoptotic cell death in a variety of cell types in diabetes, and the mechanism remains unclear. We report here that culture of rat…”
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AGEs in human lens capsule promote the TGF[beta]2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis by Raghavan, Cibin T, Smuda, Mareen, Smith, Andrew J O, Howell, Scott, Smith, Dawn G, Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A, Wormstone, Ian Michael, Nagaraj, Ram H

“…Summary Proteins in basement membrane (BM) are long-lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is…”
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Glyoxalase I Plays a Critical Role in the Prevention of High Glucose‐Induced Apoptosis in Human Retinal Pericytes by Miller, Antonia Grace, Smith, Dawn G, Nagaraj, Ram H

“…Objective We investigated whether the glyoxalase system protects human retinal pericytes (HRP) against cell death when cultured in high concentrations of…”
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Glyoxalase I Plays a Critical Role in the Prevention of High Glucose-Induced Apoptosis in Human Retinal Pericytes by Miller, Antonia G, Smith, Dawn G, Nagaraj, Ram H

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