Search Results - "Smith, David K."
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High-Tech Applications of Self-Assembling Supramolecular Nanostructured Gel-Phase Materials: From Regenerative Medicine to Electronic Devices
Published in Angewandte Chemie International Edition (06-10-2008)“…It is likely that nanofabrication will underpin many technologies in the 21st century. Synthetic chemistry is a powerful approach to generate molecular…”
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Shaping and structuring supramolecular gels
Published in Nature reviews. Materials (01-07-2019)“…Supramolecular gels assemble via non-covalent interactions between low-molecular-weight gelators (LMWGs). The gels form a solid-like nanoscale network spanning…”
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Self-Assembled Multivalency: Dynamic Ligand Arrays for High-Affinity Binding
Published in Angewandte Chemie International Edition (02-07-2012)“…Multivalency is a powerful strategy for achieving high‐affinity molecular recognition in biological systems. Recently, attention has begun to focus on using…”
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Self‐Assembling Supramolecular Hybrid Hydrogel Beads
Published in Angewandte Chemie International Edition (07-01-2020)“…With the goal of imposing shape and structure on supramolecular gels, we combine a low‐molecular‐weight gelator (LMWG) with the polymer gelator (PG) calcium…”
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Dynamic Evolving Two-Component Supramolecular GelsHierarchical Control over Component Selection in Complex Mixtures
Published in Journal of the American Chemical Society (17-04-2013)“…We report a two-component acid–amine gelation system which forms instant organogels on simple mixing. We investigate self-assembly using a wide range of…”
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Photopatterned Multidomain Gels: Multi-Component Self-Assembled Hydrogels Based on Partially Self-Sorting 1,3:2,4-Dibenzylidene‑d‑sorbitol Derivatives
Published in Journal of the American Chemical Society (16-12-2015)“…We report a multicomponent self-assembling system based on 1,3:2,4-dibenzyldene-d-sorbitol (DBS) derivatives which form gels as the pH is lowered in a…”
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Sequential Assembly of Mutually Interactive Supramolecular Hydrogels and Fabrication of Multi‐Domain Materials
Published in Chemistry : a European journal (27-08-2019)“…A two‐component self‐sorting hydrogel based on acylhydrazide and carboxylic acid derivatives of 1,3:2,4‐dibenzylidene‐d‐sorbitol (DBS‐CONHNH2 and DBS‐COOH) is…”
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Catalytic Gels for a Prebiotically Relevant Asymmetric Aldol Reaction in Water: From Organocatalyst Design to Hydrogel Discovery and Back Again
Published in Journal of the American Chemical Society (04-03-2020)“…This paper reports an investigation into organocatalytic hydrogels as prebiotically relevant systems. Gels are interesting prebiotic reaction media, combining…”
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Self‐Propelling Hybrid Gels Incorporating an Active Self‐Assembled, Low‐Molecular‐Weight Gelator
Published in Chemistry : a European journal (19-10-2021)“…Hybrid gel beads based on combining a low‐molecular‐weight gelator (LMWG) with a polymer gelator (PG) demonstrate an enhanced ability to self‐propel in water,…”
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Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Published in Nature communications (03-02-2021)“…Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among…”
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Spatial and temporal diffusion-control of dynamic multi-domain self-assembled gels
Published in Chemical science (Cambridge) (25-03-2021)“…The dynamic assembly of a pH-responsive low-molecular-weight gelator (LMWG) within the pre-formed matrix of a second LMWG has been achieved via diffusion of an…”
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Hybrid Self‐Assembled Gel Beads for Tuneable pH‐Controlled Rosuvastatin Delivery
Published in Chemistry : a European journal (15-09-2021)“…This article describes the fabrication of new pH‐responsive hybrid gel beads combining the polymer gelator calcium alginate with two different…”
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Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low-Molecular-Weight Gelators
Published in Angewandte Chemie International Edition (10-11-2014)“…A simple approach to a patterned multidomain gel is reported, combining a pH‐responsive low‐molecular‐weight gelator (LMWG) and a photoinducible polymer…”
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Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
Published in Science (American Association for the Advancement of Science) (01-01-2016)“…Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir…”
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Self-assembled low-molecular-weight gelator injectable microgel beads for delivery of bioactive agents
Published in Chemical science (Cambridge) (02-02-2021)“…We report the preparation of hybrid self-assembled microgel beads by combining the low molecular weight gelator (LMWG) DBS-CONHNH 2 and the natural…”
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Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus
Published in BMC evolutionary biology (19-08-2010)“…The influenza A virus is an important infectious cause of morbidity and mortality in humans and was responsible for 3 pandemics in the 20th century. As the…”
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Multi-component hybrid hydrogels - understanding the extent of orthogonal assembly and its impact on controlled release
Published in Chemical science (Cambridge) (01-10-2017)“…This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component…”
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The genesis and source of the H7N9 influenza viruses causing human infections in China
Published in Nature (London) (10-10-2013)“…Evolutionary analyses show that H7 influenza viruses probably transferred from ducks to chickens in China on at least two independent occasions, and that…”
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Modeling the Multivalent Recognition between Dendritic Molecules and DNA: Understanding How Ligand “Sacrifice” and Screening Can Enhance Binding
Published in Journal of the American Chemical Society (22-07-2009)“…This paper reports the application of molecular dynamics methods to understand the interactions between dendritic molecules with spermine surface groups and…”
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Vertebral pneumaticity of the North American therizinosaur Nothronychus
Published in Journal of anatomy (01-03-2021)“…Nothronychus was a large, derived therizinosaur from the Upper Cretaceous of Utah and New Mexico. The genus is known from elements that have been referred to…”
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