Search Results - "Smith, David C"
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Five-Year Follow-Up of Nivolumab in Previously Treated Advanced Non-Small-Cell Lung Cancer: Results From the CA209-003 Study
Published in Journal of clinical oncology (10-06-2018)“…Purpose In two phase III studies, nivolumab, a programmed death-1 (PD-1) inhibitor antibody, improved overall survival (OS) versus docetaxel in pretreated…”
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Global distribution of microbial abundance and biomass in subseafloor sediment
Published in Proceedings of the National Academy of Sciences - PNAS (02-10-2012)“…The global geographic distribution of subseafloor sedimentary microbes and the cause(s) of that distribution are largely unexplored. Here, we show that total…”
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Bacterial diversity and community composition from seasurface to subseafloor
Published in The ISME Journal (01-04-2016)“…We investigated compositional relationships between bacterial communities in the water column and those in deep-sea sediment at three environmentally distinct…”
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An integrated approach is needed for ecosystem based fisheries management: insights from ecosystem-level management strategy evaluation
Published in PloS one (13-01-2014)“…An ecosystem approach is widely seen as a desirable goal for fisheries management but there is little consensus on what strategies or measures are needed to…”
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Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012
Published in Journal of clinical oncology (01-04-2018)“…Purpose To determine whether cotargeting poly (ADP-ribose) polymerase-1 plus androgen receptor is superior to androgen receptor inhibition in metastatic…”
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Cabozantinib in Patients With Advanced Prostate Cancer: Results of a Phase II Randomized Discontinuation Trial
Published in Journal of clinical oncology (01-02-2013)“…Cabozantinib (XL184) is an orally bioavailable tyrosine kinase inhibitor with activity against MET and vascular endothelial growth factor receptor 2. We…”
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The contribution of water radiolysis to marine sedimentary life
Published in Nature communications (26-02-2021)“…Water radiolysis continuously produces H 2 and oxidized chemicals in wet sediment and rock. Radiolytic H 2 has been identified as the primary electron donor…”
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Personalized oncology through integrative high-throughput sequencing: a pilot study
Published in Science translational medicine (30-11-2011)“…Individual cancers harbor a set of genetic aberrations that can be informative for identifying rational therapies currently available or in clinical trials. We…”
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American Society of Clinical Oncology Clinical Practice Guideline on Uses of Serum Tumor Markers in Adult Males With Germ Cell Tumors
Published in Journal of clinical oncology (10-07-2010)“…To provide recommendations on appropriate uses for serum markers of germ cell tumors (GCTs). Searches of MEDLINE and EMBASE identified relevant studies…”
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Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study
Published in Journal of clinical oncology (20-10-2014)“…Cabozantinib (XL184), an oral inhibitor of multiple receptor tyrosine kinases such as MET and VEGFR2, was evaluated in a phase II nonrandomized expansion study…”
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Atribacteria Reproducing over Millions of Years in the Atlantic Abyssal Subseafloor
Published in mBio (06-10-2020)“…The deep subseafloor sedimentary biosphere is one of the largest ecosystems on Earth, where microbes subsist under energy-limited conditions over long…”
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Subseafloor sedimentary life in the South Pacific Gyre
Published in Proceedings of the National Academy of Sciences - PNAS (14-07-2009)“…The low-productivity South Pacific Gyre (SPG) is Earth's largest oceanic province. Its sediment accumulates extraordinarily slowly (0.1-1 m per million years)…”
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Trastuzumab, Paclitaxel, Carboplatin, and Gemcitabine in Advanced Human Epidermal Growth Factor Receptor-2/neu–Positive Urothelial Carcinoma: Results of a Multicenter Phase II National Cancer Institute Trial
Published in Journal of clinical oncology (01-06-2007)“…We investigated the safety and efficacy (response rates, time to disease progression, survival) of trastuzumab, carboplatin, gemcitabine, and paclitaxel in…”
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Among-stock comparisons for improving stock assessments of data-poor stocks: the “Robin Hood” approach
Published in ICES journal of marine science (01-05-2011)“…Abstract Punt, A. E., Smith, D. C., and Smith, A. D. M. 2011. Among-stock comparisons for improving stock assessments of data-poor stocks: the “Robin Hood”…”
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Growth of nanowire superlattice structures for nanoscale photonics and electronics
Published in Nature (London) (07-02-2002)“…The assembly of semiconductor nanowires and carbon nanotubes into nanoscale devices and circuits could enable diverse applications in nanoelectronics and…”
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Multiplex Quantitative Real-Time Reverse Transcriptase PCR for F⁺-Specific RNA Coliphages: a Method for Use in Microbial Source Tracking
Published in Applied and Environmental Microbiology (01-02-2007)“…It is well documented that microbial contamination of coastal waters poses a significant risk to human health through recreational exposure and consumption of…”
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U.S. International Equity Investment
Published in Journal of accounting research (01-12-2012)“…Using a comprehensive data set of all U.S. investment in foreign equities, we find that the single most important determinant of the amount of U.S. investment…”
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First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy
Published in Cancer management and research (01-12-2019)“…This first-in-human Phase I study investigated the safety, pharmacokinetics (PK), pharmacodynamic profile, and preliminary efficacy of CC-115, a dual inhibitor…”
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Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Published in International journal of molecular sciences (21-12-2021)“…The substantial biological heterogeneity of metastatic prostate cancer has hindered the development of personalized therapeutic approaches. Therefore, it is…”
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The ecosystem approach to fisheries: management at the dynamic interface between biodiversity conservation and sustainable use
Published in Annals of the New York Academy of Sciences (01-08-2014)“…The emergence of an ecosystem approach to fisheries (EAF) was characterized by the adoption of objectives for maintaining ecosystem health alongside those for…”
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