Search Results - "Smith, Dana L."

Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length by Xie, Zhengwei, Jay, Kyle A., Smith, Dana L., Zhang, Yi, Liu, Zairan, Zheng, Jiashun, Tian, Ruilin, Li, Hao, Blackburn, Elizabeth H.

“…Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after…”
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Telomere length measurement by qPCR – Summary of critical factors and recommendations for assay design by Lin, Jue, Smith, Dana L., Esteves, Kyle, Drury, Stacy

“…•Telomere length has been investigated as a cellular aging biomarker for environmental exposure and life style factors.•Inconsistencies using the qPCR telomere…”
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Early maternal separation is not associated with changes in telomere length in domestic kittens ( Felis catus ) by Delgado, Mikel, Buffington, C A Tony, Bain, Melissa, Smith, Dana L, Vernau, Karen

“…Studies of multiple species have found that adverse early life experiences, including childhood trauma and maternal separation, can result in accelerated…”
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Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break by Anderson, Carol M, Korkin, Dmitry, Smith, Dana L, Makovets, Svetlana, Seidel, Jeffrey J, Sali, Andrej, Blackburn, Elizabeth H

“…The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an…”
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Budding Yeast Cdc20: A Target of the Spindle Checkpoint by Hwang, Lena H., Lau, Lucius F., Smith, Dana L., Mistrot, Cathy A., Hardwick, Kevin G., Hwang, Ellen S., Amon, Angelika, Murray, Andrew W.

“…The spindle checkpoint regulates the cell division cycle by keeping cells with defective spindles from leaving mitosis. In the two-hybrid system, three…”
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Telomere Length Is Associated with Disability Progression in Multiple Sclerosis by Krysko, Kristen M., Henry, Roland G., Cree, Bruce A. C., Lin, Jue, Caillier, Stacy, Santaniello, Adam, Zhao, Chao, Gomez, Refujia, Bevan, Carolyn, Smith, Dana L., Stern, William, Kirkish, Gina, Hauser, Stephen L., Oksenberg, Jorge R., Graves, Jennifer S.

“…Objective To assess whether biological aging as measured by leukocyte telomere length (LTL) is associated with clinical disability and brain volume loss in…”
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Interferon-signaling pathways are upregulated in people with HIV with abnormal pulmonary diffusing capacity (DL CO ) by Zhang, Michelle, Dai, Guorui, Smith, Dana L, Zacco, Emanuela, Shimoda, Michiko, Kumar, Nitasha, Girling, Valerie, Gardner, Kendall, Hunt, Peter W, Huang, Laurence, Lin, Jue

“…People with HIV (PWH) are at greater risk of developing lung diseases even when they are antiretroviral therapy (ART)-adherent and virally suppressed. The most…”
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Association of telomere length with risk of complications in adult spinal deformity surgery: a pilot study of 43 patients by Safaee, Michael M, Lin, Jue, Smith, Dana L, Fury, Marissa, Scheer, Justin K, Burke, John F, Bravate, Crystal, Lambert, Dennis, Ames, Christopher P

“…Risk stratification is a critical element of surgical planning. Early tools were fairly crude, while newer instruments incorporate disease-specific elements…”
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Epigenetic age biomarkers and risk assessment in adult spinal deformity: a novel association of biological age with frailty and disability by Safaee, Michael M, Dwaraka, Varun B, Lee, Justin M, Fury, Marissa, Mendez, Tavis L, Smith, Ryan, Lin, Jue, Smith, Dana L, Burke, John F, Scheer, Justin K, Went, Hannah, Ames, Christopher P

“…Surgery for spinal deformity has the potential to improve pain, disability, function, self-image, and mental health. These surgical procedures carry…”
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Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program by Rehkopf, David H, Wojcicki, Janet M, Haydel, K Farish, Lin, Jue, Smith, Dana L, Kapphahn, Kristopher I, Robinson, Thomas N

“…To examine changes in leukocyte telomere length (LTL) during and after a behavioural weight control program for children with obesity. We measured LTL among a…”
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Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins by Jay, Kyle A., Smith, Dana L., Blackburn, Elizabeth H.

“…Telomeres cap the ends of chromosomes, protecting them from degradation and inappropriate DNA repair processes that can lead to genomic instability. A short…”
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Impact of a nutritional supplement during gestation and early childhood on child salivary cortisol, hair cortisol, and telomere length at 4-6 years of age: a follow-up of a randomized controlled trial by Oaks, Brietta M, Adu-Afarwuah, Seth, Kumordzie, Sika, Laudenslager, Mark L, Smith, Dana L, Lin, Jue, Young, Rebecca R, Arnold, Charles D, Bentil, Helena, Okronipa, Harriet, Ocansey, Maku, Dewey, Kathryn G

“…Dysregulation of the stress response can occur early in life and may be affected by nutrition. Our objective was to evaluate the long-term effect of…”
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Genes Involved in Sister Chromatid Separation and Segregation in the Budding Yeast Saccharomyces cerevisiae by Biggins, Sue, Bhalla, Needhi, Chang, Amy, Smith, Dana L, Murray, Andrew W

“…Accurate chromosome segregation requires the precise coordination of events during the cell cycle. Replicated sister chromatids are held together while they…”
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MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p by Hardwick, K.G, Johnston, R.C, Smith, D.L, Murray, A.W

“…We show that MAD3 encodes a novel 58-kD nuclear protein which is not essential for viability, but is an integral component of the spindle checkpoint in budding…”
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Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response by Lin, Jue, Smith, Dana L, Blackburn, Elizabeth H

“…Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence…”
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Genetic Selection of Peptide Inhibitors of Biological Pathways by Norman, Thea C., Smith, Dana L., Sorger, Peter K., Drees, Becky L., O'Rourke, Sean M., Hughes, Timothy R., Roberts, Christopher J., Friend, Stephen H., Fields, Stan, Murray, Andrew W.

“…Genetic selections were used to find peptides that inhibit biological pathways in budding yeast. The peptides were presented inside cells as peptamers, surface…”
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Mutant Telomere Sequences Lead to Impaired Chromosome Separation and a Unique Checkpoint ResponseD by Lin, Jue, Smith, Dana L., Blackburn, Elizabeth H.

“…Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence…”
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DNA bending by the a1 and α2 homeodomain proteins from yeast by Smith, Dana L., Desai, Arshad B., Johnson, Alexander D.

“…ABSTRACT Structural and biochemical studies of monomer homeodomain-DNA complexes have not so far revealed any cases of pronounced DNA distortion. In this paper…”
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Epidemiology of Colonization by Nontypable Haemophilus influenzae in Children: A Longitudinal Study by Spinola, Stanley M., Peacock, James, Denny, Floyd W., Smith, Dana L., Cannon, Janne G.

“…Eighty-six nasopharyngeal isolates of Haemophilus influenzae were prospectively obtained from three children who attended a day care center from infancy until…”
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