Search Results - "Smith, Colin P"

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis by TRIPKOVIC, Laura, LAMBERT, Helen, LANHAM-NEW, Susan, HART, Kathryn, SMITH, Colin P, BUCCA, Giselda, PENSON, Simon, CHOPE, Gemma, HYPPÖNEN, Elina, BERRY, Jacqueline, VIETH, Reinhold

“…Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising…”
Get full text

The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2) by Jeong, Yujin, Kim, Ji-Nu, Kim, Min Woo, Bucca, Giselda, Cho, Suhyung, Yoon, Yeo Joon, Kim, Byung-Gee, Roe, Jung-Hye, Kim, Sun Chang, Smith, Colin P., Cho, Byung-Kwan

“…Individual Streptomyces species have the genetic potential to produce a diverse array of natural products of commercial, medical and veterinary interest…”
Get full text

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome by Möller-Levet, Carla S, Archer, Simon N, Bucca, Giselda, Laing, Emma E, Slak, Ana, Kabiljo, Renata, Lo, June C Y, Santhi, Nayantara, von Schantz, Malcolm, Smith, Colin P, Dijk, Derk-Jan

“…Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, including obesity, cardiovascular disease, and cognitive…”
Get full text

Mistimed sleep disrupts circadian regulation of the human transcriptome by Archer, Simon N, Laing, Emma E, Möller-Levet, Carla S, van der Veen, Daan R, Bucca, Giselda, Lazar, Alpar S, Santhi, Nayantara, Slak, Ana, Kabiljo, Renata, von Schantz, Malcolm, Smith, Colin P, Dijk, Derk-Jan

“…Circadian organization of the mammalian transcriptome is achieved by rhythmic recruitment of key modifiers of chromatin structure and transcriptional and…”
Get full text

Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase by Flaherty, Renée L., Intabli, Haya, Falcinelli, Marta, Bucca, Giselda, Hesketh, Andrew, Patel, Bhavik A., Allen, Marcus C., Smith, Colin P., Flint, Melanie S.

“…Stress hormones have been shown to be important mediators in driving malignant growth and reducing treatment efficacy in breast cancer. Glucocorticoids can…”
Get full text

Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line by Mengozzi, Manuela, Hesketh, Andrew, Bucca, Giselda, Ghezzi, Pietro, Smith, Colin P

“…Vitamin D deficiency increases the risk of developing multiple sclerosis (MS) but it is unclear whether vitamin D supplementation improves the clinical course…”
Get full text

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome by Durrant, Louise R., Bucca, Giselda, Hesketh, Andrew, Möller-Levet, Carla, Tripkovic, Laura, Wu, Huihai, Hart, Kathryn H., Mathers, John C., Elliott, Ruan M., Lanham-New, Susan A., Smith, Colin P.

“…Vitamin D is best known for its role in maintaining bone health and calcium homeostasis. However, it also exerts a broad range of extra-skeletal effects on…”
Get full text

Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets by Świątek-Połatyńska, Magdalena A, Bucca, Giselda, Laing, Emma, Gubbens, Jacob, Titgemeyer, Fritz, Smith, Colin P, Rigali, Sébastien, van Wezel, Gilles P

“…Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and…”
Get full text

Chemotranscriptomic Profiling Defines Drug-Specific Signatures of the Glycopeptide Antibiotics Dalbavancin, Vancomycin and Chlorobiphenyl-Vancomycin in a VanB-Type-Resistant Streptomycete by Hesketh, Andy, Bucca, Giselda, Smith, Colin P, Hong, Hee-Jeon

“…Dalbavancin, vancomycin and chlorobiphenyl-vancomycin share a high degree of structural similarity and the same primary mode of drug action. All inhibit…”
Get full text

Vitamin D and SARS-CoV-2 virus/COVID-19 disease by Lanham-New, Susan A, Webb, Ann R, Cashman, Kevin D, Buttriss, Judy L, Fallowfield, Joanne L, Masud, Tash, Hewison, Martin, Mathers, John C, Kiely, Mairead, Welch, Ailsa A, Ward, Kate A, Magee, Pamela, Darling, Andrea L, Hill, Tom R, Greig, Carolyn, Smith, Colin P, Murphy, Richard, Leyland, Sarah, Bouillon, Roger, Ray, Sumantra, Kohlmeier, Martin

“…In light of the current COVID-19 pandemic, and given the importance of diet to overall health and well-being, nutrients (macro and micro) deserve special…”
Get full text

Antibiotic Overproduction in Streptomyces coelicolor A3(2) Mediated by Phosphofructokinase Deletion by Borodina, Irina, Siebring, Jeroen, Zhang, Jie, Smith, Colin P., van Keulen, Geertje, Dijkhuizen, Lubbert, Nielsen, Jens

“…Streptomycetes are exploited for production of a wide range of secondary metabolites, and there is much interest in enhancing the level of production of these…”
Get full text

Genome-wide analysis of the role of the antibiotic biosynthesis regulator AbsA2 in Streptomyces coelicolor A3(2) by Lewis, Richard A, Wahab, Abdul, Bucca, Giselda, Laing, Emma E, Möller-Levet, Carla S, Kierzek, Andrzej, Smith, Colin P

“…The AbsA1-AbsA2 two component signalling system of Streptomyces coelicolor has long been known to exert a powerful negative influence on the production of the…”
Get full text

One of the Two Genes Encoding Nucleoid-Associated HU Proteins in Streptomyces coelicolor Is Developmentally Regulated and Specifically Involved in Spore Maturation by SALERNO, Paola, LARSSON, Jessica, BUCCA, Giselda, LAING, Emma, SMITH, Colin P, FLÄRDH, Klas

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

ROK Family Regulator Rok7B7 Pleiotropically Affects Xylose Utilization, Carbon Catabolite Repression, and Antibiotic Production in Streptomyces coelicolor by Świątek, Magdalena A, Gubbens, Jacob, Bucca, Giselda, Song, Eunjung, Yang, Yung-Hun, Laing, Emma, Kim, Byung-Gee, Smith, Colin P, van Wezel, Gilles P

“…Members of the ROK family of proteins are mostly transcriptional regulators and kinases that generally relate to the control of primary metabolism, whereby its…”
Get full text

A bacterial hormone (the SCB1) directly controls the expression of a pathway‐specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor by Takano, Eriko, Kinoshita, Hiroshi, Mersinias, Vassilis, Bucca, Giselda, Hotchkiss, Graham, Nihira, Takuya, Smith, Colin P., Bibb, Mervyn, Wohlleben, Wolfgang, Chater, Keith

“…Summary Gamma‐butyrolactone signalling molecules are produced by many Streptomyces species, and several have been shown to regulate antibiotic production. In…”
Get full text

An example of designed multiple ligands spanning protein classes: Dual MCH-1R antagonists/DPPIV inhibitors by Gattrell, William T., Sambrook Smith, Colin P., Smith, Alun J.

“…A ligand-based approach to identify potential starting points for a dual MCH-1R antagonist/DPPIV inhibitor medicinal chemistry program was undertaken…”
Get full text

RankProdIt: A web-interactive Rank Products analysis tool by Laing, Emma, Smith, Colin P

“…The first objective of a DNA microarray experiment is typically to generate a list of genes or probes that are found to be differentially expressed or…”
Get full text

New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures by Hesketh, Andy, Bucca, Giselda, Laing, Emma, Flett, Fiona, Hotchkiss, Graham, Smith, Colin P, Chater, Keith F

“…In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of…”
Get full text

Doctors in support of law reform for voluntary euthanasia by Willoughby, John O, Marr, Robert G, Wendell‐Smith, Colin P

Get full text

Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization by Lewis, Richard A, Laing, Emma, Allenby, Nicholas, Bucca, Giselda, Brenner, Volker, Harrison, Marcus, Kierzek, Andrzej M, Smith, Colin P

“…Whilst being closely related to the model actinomycete Streptomyces coelicolor A3(2), S. lividans 66 differs from it in several significant and phenotypically…”
Get full text