Search Results - "Smith, Clare V."

Crystal Structures of Mycolic Acid Cyclopropane Synthases from Mycobacterium tuberculosis by Huang, Chih-chin, Smith, Clare V., Glickman, Michael S., Jacobs, William R., Sacchettini, James C.

“…Mycolic acids are major components of the cell wall of Mycobacterium tuberculosis. Several studies indicate that functional groups in the acyl chain of mycolic…”
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Crystal structure of the breakage-reunion domain of DNA gyrase by Liddington, Robert C, Cabral, Joo H. Morais, Jackson, Andrew P, Smith, Clare V, Shikotra, Nita, Maxwell, Anthony

“…DNA gyrase is a type II DNA topoisomerase from bacteria that introduces supercoils into DNA,. It catalyses the breakage of a DNA duplex (the G segment), the…”
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Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis by Smith, Clare V, Huang, Chih-chin, Miczak, Andras, Russell, David G, Sacchettini, James C, Höner zu Bentrup, Kerstin

“…Establishment or maintenance of a persistent infection by Mycobacterium tuberculosis requires the glyoxylate pathway. This is a bypass of the tricarboxylic…”
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TB drug discovery: addressing issues of persistence and resistance by Smith, Clare V, Sharma, Vivek, Sacchettini, James C

“…Tuberculosis remains a leading cause of mortality worldwide into the 21st century. Among the main obstacles to the global control of the disease are emerging…”
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Mycobacterium tuberculosis: a model system for structural genomics by Smith, Clare V, Sacchettini, James C

“…Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains…”
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DRIP150 Coactivation of Estrogen Receptor α in ZR-75 Breast Cancer Cells Is Independent of LXXLL Motifs by Lee, Jeongeun Eun, Kim, Kyounghyun, Sacchettini, James C., Smith, Clare V., Safe, Stephen

“…Vitamin D receptor-interacting protein 150 (DRIP150) has been identified as part of mediator-like complexes that enhance transcriptional activation of the…”
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Identification of a Residue Involved in Transition-State Stabilization in the ATPase Reaction of DNA Gyrase by Smith, Clare V, Maxwell, Anthony

“…Examination of the X-ray crystal structure of the 43 kDa N-terminal domain of the DNA gyrase B protein (GyrB) shows that the majority of the interactions with…”
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Biochemical and Structural Studies of Malate Synthase fromMycobacterium tuberculosis by Smith, Clare V., Huang, Chih-chin, Miczak, Andras, Russell, David G., Sacchettini, James C., Höner zu Bentrup, Kerstin

“…Establishment or maintenance of a persistent infection by Mycobacterium tuberculosis requires the glyoxylate pathway. This is a bypass of the tricarboxylic…”
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The TB structural genomics consortium: providing a structural foundation for drug discovery by Goulding, Celia W, Apostol, Marcin, Anderson, Daniel H, Gill, Harindarpal S, Smith, Clare V, Kuo, Mack R, Yang, Jin Kuk, Waldo, Geoffrey S, Suh, Se Won, Chauhan, Radha, Kale, Avinash, Bachhawat, Nandita, Mande, Shekhar C, Johnston, Jodie M, Lott, J Shaun, Baker, Edward N, Arcus, Vickery L, Leys, David, McLean, Kirsty J, Munro, Andrew W, Berendzen, Joel, Sharma, Vivek, Park, Min S, Eisenberg, David, Sacchettini, James, Alber, Tom, Rupp, Bernhard, Jacobs, Jr, William, Terwilliger, Thomas C

“…Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The…”
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The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography by Lewis, R. J., Singh, O. M., Smith, C. V., Skarzynski, T., Maxwell, A., Wonacott, A. J., Wigley, D. B.

“…This study describes the first crystal structures of a complex between a DNA topoisomerase and a drug. We present the structures of a 24 kDa N‐terminal…”
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DRIP150 Coactivation of Estrogen Receptor α in ZR-75 Breast Cancer Cells Is Independent of LXXLL Motifs by Jeongeun Eun Lee, Kyounghyun Kim, James C. Sacchettini, Clare V. Smith, Stephen Safe

“…Vitamin D receptor-interacting protein 150 (DRIP150) has been identified as part of mediator-like complexes that enhance transcriptional activation of the…”
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Crystal Structures of Mycolic Acid Cyclopropane Synthases fromMycobacterium tuberculosis by Chih-chin Huang, Clare V. Smith, Michael S. Glickman, William R. Jacobs, Jr, James C. Sacchettini

“…Mycolic acids are major components of the cell wall of Mycobacterium tuberculosis . Several studies indicate that functional groups in the acyl chain of…”
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Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein by Lewis, R J, Singh, O M, Smith, C V, Maxwell, A, Skarzynski, T, Wonacott, A J, Wigley, D B

“…A 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein has been crystallized in the presence of novobiocin. One crystal form has been…”
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Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase by ORAM, M, BHUPINDER DOSANJH, GORMLEY, N. A, SMITH, C. V, FISHER, L. M, MAXWELL, A, DUNCAN, K

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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