Search Results - "Smith, Christopher G."

Enhanced detection of circulating tumor DNA by fragment size analysis by Mouliere, Florent, Chandrananda, Dineika, Piskorz, Anna M, Moore, Elizabeth K, Morris, James, Ahlborn, Lise Barlebo, Mair, Richard, Goranova, Teodora, Marass, Francesco, Heider, Katrin, Wan, Jonathan C M, Supernat, Anna, Hudecova, Irena, Gounaris, Ioannis, Ros, Susana, Jimenez-Linan, Mercedes, Garcia-Corbacho, Javier, Patel, Keval, Østrup, Olga, Murphy, Suzanne, Eldridge, Matthew D, Gale, Davina, Stewart, Grant D, Burge, Johanna, Cooper, Wendy N, van der Heijden, Michiel S, Massie, Charles E, Watts, Colin, Corrie, Pippa, Pacey, Simon, Brindle, Kevin M, Baird, Richard D, Mau-Sørensen, Morten, Parkinson, Christine A, Smith, Christopher G, Brenton, James D, Rosenfeld, Nitzan

“…Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alterations but have rarely considered the biological properties…”
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Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies by Venderbosch, Sabine, Nagtegaal, Iris D, Maughan, Tim S, Smith, Christopher G, Cheadle, Jeremy P, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T, Richman, Susan D, Meijer, Gerrit A, Ylstra, Bauke, Heideman, Danielle A M, de Haan, Anton F J, Punt, Cornelis J A, Koopman, Miriam

“…To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal…”
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Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients by Mouliere, Florent, Mair, Richard, Chandrananda, Dineika, Marass, Francesco, Smith, Christopher G, Su, Jing, Morris, James, Watts, Colin, Brindle, Kevin M, Rosenfeld, Nitzan

“…Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF)…”
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ctDNA monitoring using patient-specific sequencing and integration of variant reads by Wan, Jonathan C M, Heider, Katrin, Gale, Davina, Murphy, Suzanne, Fisher, Eyal, Mouliere, Florent, Ruiz-Valdepenas, Andrea, Santonja, Angela, Morris, James, Chandrananda, Dineika, Marshall, Andrea, Gill, Andrew B, Chan, Pui Ying, Barker, Emily, Young, Gemma, Cooper, Wendy N, Hudecova, Irena, Marass, Francesco, Mair, Richard, Brindle, Kevin M, Stewart, Grant D, Abraham, Jean E, Caldas, Carlos, Rassl, Doris M, Rintoul, Robert C, Alifrangis, Constantine, Middleton, Mark R, Gallagher, Ferdia A, Parkinson, Christine, Durrani, Amer, McDermott, Ultan, Smith, Christopher G, Massie, Charles, Corrie, Pippa G, Rosenfeld, Nitzan

“…Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detection of ctDNA can be challenging in patients with low-volume…”
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Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models by Mair, Richard, Mouliere, Florent, Smith, Christopher G, Chandrananda, Dineika, Gale, Davina, Marass, Francesco, Tsui, Dana W Y, Massie, Charles E, Wright, Alan J, Watts, Colin, Rosenfeld, Nitzan, Brindle, Kevin M

“…The factors responsible for the low detection rate of cell-free tumor DNA (ctDNA) in the plasma of patients with glioblastoma (GBM) are currently unknown. In…”
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Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients by Mouliere, Florent, Smith, Christopher G, Heider, Katrin, Su, Jing, van der Pol, Ymke, Thompson, Mareike, Morris, James, Wan, Jonathan C M, Chandrananda, Dineika, Hadfield, James, Grzelak, Marta, Hudecova, Irena, Couturier, Dominique‐Laurent, Cooper, Wendy, Zhao, Hui, Gale, Davina, Eldridge, Matthew, Watts, Colin, Brindle, Kevin, Rosenfeld, Nitzan, Mair, Richard

“…Glioma‐derived cell‐free DNA (cfDNA) is challenging to detect using liquid biopsy because quantities in body fluids are low. We determined the glioma‐derived…”
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Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial by Maughan, Timothy S, Prof, Adams, Richard A, FRCP, Smith, Christopher G, BSc, Meade, Angela M, DPhil, Seymour, Matthew T, Prof, Wilson, Richard H, MD, Idziaszczyk, Shelley, MPhil, Harris, Rebecca, MSc, Fisher, David, MSc, Kenny, Sarah L, MSc, Kay, Edward, BA, Mitchell, Jenna K, BHSc, Madi, Ayman, MRCP, Jasani, Bharat, Prof, James, Michelle D, BSc, Bridgewater, John, MD, Kennedy, M John, MD, Claes, Bart, MSc, Lambrechts, Diether, PhD, Kaplan, Richard, Prof, Cheadle, Jeremy P, Prof

“…Summary Background In the Medical Research Council (MRC) COIN trial, the epidermal growth factor receptor (EGFR)-targeted antibody cetuximab was added to…”
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Refined characterization of circulating tumor DNA through biological feature integration by Markus, Havell, Chandrananda, Dineika, Moore, Elizabeth, Mouliere, Florent, Morris, James, Brenton, James D., Smith, Christopher G., Rosenfeld, Nitzan

“…Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell-free DNA (cfDNA) of non-tumor origin. To enhance ctDNA…”
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The Magnitude and Origin of Groundwater Discharge to Eastern U.S. and Gulf of Mexico Coastal Waters by Befus, Kevin M., Kroeger, Kevin D., Smith, Christopher G., Swarzenski, Peter W.

“…Fresh groundwater discharge to coastal environments contributes to the physical and chemical conditions of coastal waters, but the role of coastal groundwater…”
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Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors by Smith, Christopher G, Moser, Tina, Mouliere, Florent, Field-Rayner, Johanna, Eldridge, Matthew, Riediger, Anja L, Chandrananda, Dineika, Heider, Katrin, Wan, Jonathan C M, Warren, Anne Y, Morris, James, Hudecova, Irena, Cooper, Wendy N, Mitchell, Thomas J, Gale, Davina, Ruiz-Valdepenas, Andrea, Klatte, Tobias, Ursprung, Stephan, Sala, Evis, Riddick, Antony C P, Aho, Tevita F, Armitage, James N, Perakis, Samantha, Pichler, Martin, Seles, Maximilian, Wcislo, Gabriel, Welsh, Sarah J, Matakidou, Athena, Eisen, Tim, Massie, Charles E, Rosenfeld, Nitzan, Heitzer, Ellen, Stewart, Grant D

“…Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. Here, a…”
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Reconciling models and measurements of marsh vulnerability to sea level rise by Coleman, Daniel J., Schuerch, Mark, Temmerman, Stijn, Guntenspergen, Glenn, Smith, Christopher G., Kirwan, Matthew L.

“…Tidal marsh survival in the face of sea level rise (SLR) and declining sediment supply often depends on the ability of marshes to build soil vertically…”
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BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer by Summers, Matthew G, Smith, Christopher G, Maughan, Timothy S, Kaplan, Richard, Escott-Price, Valentina, Cheadle, Jeremy P

“…Somatic mutation status at , and is associated with prognosis in patients with advanced colorectal cancer (aCRC); however, it remains unclear whether there are…”
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Dynamics of multiple resistance mechanisms in plasma DNA during EGFR‐targeted therapies in non‐small cell lung cancer by Tsui, Dana Wai Yi, Murtaza, Muhammed, Wong, Alvin Seng Cheong, Rueda, Oscar M, Smith, Christopher G, Chandrananda, Dineika, Soo, Ross A, Lim, Hong Liang, Goh, Boon Cher, Caldas, Carlos, Forshew, Tim, Gale, Davina, Liu, Wei, Morris, James, Marass, Francesco, Eisen, Tim, Chin, Tan Min, Rosenfeld, Nitzan

“…Tumour heterogeneity leads to the development of multiple resistance mechanisms during targeted therapies. Identifying the dominant driver(s) is critical for…”
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An investigation of submarine groundwater–borne nutrient fluxes to the west Florida shelf and recurrent harmful algal blooms by Smith, Christopher G., Swarzenski, Peter W.

“…A cross-shelf, water-column mass balance of radon-222 (222Rn) provided estimates of submarine groundwater discharge (SGD), which were then used to quantify…”
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Influence of sea level rise on iron diagenesis in an east Florida subterranean estuary by Roy, Moutusi, Martin, Jonathan B., Cherrier, Jennifer, Cable, Jaye E., Smith, Christopher G.

“…Subterranean estuary occupies the transition zone between hypoxic fresh groundwater and oxic seawater, and between terrestrial and marine sediment deposits…”
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Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer by Santonja, Angela, Cooper, Wendy N, Eldridge, Matthew D, Edwards, Paul A W, Morris, James A, Edwards, Abigail R, Zhao, Hui, Heider, Katrin, Couturier, Dominique‐Laurent, Vijayaraghavan, Aadhitthya, Mennea, Paulius, Ditter, Emma‐Jane, Smith, Christopher G, Boursnell, Chris, Manzano García, Raquel, Rueda, Oscar M, Beddowes, Emma, Biggs, Heather, Sammut, Stephen‐John, Rosenfeld, Nitzan, Caldas, Carlos, Abraham, Jean E, Gale, Davina

“…Analysis of circulating tumor DNA (ctDNA) to monitor cancer dynamics and detect minimal residual disease has been an area of increasing interest. Multiple…”
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Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma by Pinheiro, Kelly V., Thomaz, Amanda, Souza, Bárbara Kunzler, Metcalfe, Victoria Anne, Freire, Natália Hogetop, Brunetto, André Tesainer, de Farias, Caroline Brunetto, Jaeger, Mariane, Bambini, Victorio, Smith, Christopher G. S., Shaw, Lisa, Roesler, Rafael

“…A member of the Trk family of neurotrophin receptors, tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene) is an increasingly important target in…”
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Modeling the effects of interior headland restoration on estuarine sediment transport processes in a marine-dominant estuary by Jenkins, Robert L., Passeri, Davina L., Smith, Christopher G., Thompson, David M., Smith, Kathryn E. L.

“…The effects of interior headland restoration on estuarine sediment transport processes were assessed through process-based numerical modeling. Three proposed…”
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A Resident's Perspective of Ovarian Cancer by Smith, Christopher G

“…Identifying, understanding, and curing disease is a lifelong endeavor for any medical practitioner. Equally as important is to be cognizant of the impact a…”
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Episodic High Intensity Mixing Events in a Subterranean Estuary: Effects of Tropical Cyclones by Smith, Christopher G., Cable, Jaye E., Martin, Jonathan B.

“…Hydrostatic balances between fresh and saline groundwater and saline surface water control the physical and chemical framework of subterranean estuaries, but…”
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