Search Results - "Smith, Christian A"

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants by Pajtler, Kristian W., Mack, Stephen C., Ramaswamy, Vijay, Smith, Christian A., Witt, Hendrik, Smith, Amy, Hansford, Jordan R., von Hoff, Katja, Wright, Karen D., Hwang, Eugene, Frappaz, Didier, Kanemura, Yonehiro, Massimino, Maura, Faure-Conter, Cécile, Modena, Piergiorgio, Tabori, Uri, Warren, Katherine E., Holland, Eric C., Ichimura, Koichi, Giangaspero, Felice, Castel, David, von Deimling, Andreas, Kool, Marcel, Dirks, Peter B., Grundy, Richard G., Foreman, Nicholas K., Gajjar, Amar, Korshunov, Andrey, Finlay, Jonathan, Gilbertson, Richard J., Ellison, David W., Aldape, Kenneth D., Merchant, Thomas E., Bouffet, Eric, Pfister, Stefan M., Taylor, Michael D.

“…Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three…”
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PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma by Agnihotri, Sameer, Golbourn, Brian, Huang, Xi, Remke, Marc, Younger, Susan, Cairns, Rob A, Chalil, Alan, Smith, Christian A, Krumholtz, Stacey-Lynn, Mackenzie, Danielle, Rakopoulos, Patricia, Ramaswamy, Vijay, Taccone, Michael S, Mischel, Paul S, Fuller, Gregory N, Hawkins, Cynthia, Stanford, William L, Taylor, Michael D, Zadeh, Gelareh, Rutka, James T

“…Proliferating cancer cells are characterized by high rates of glycolysis, lactate production, and altered mitochondrial metabolism. This metabolic…”
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Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound by Etame, Arnold B., MD, Diaz, Roberto J., MD, O'Reilly, Meaghan A., MSc, Smith, Christian A., PhD, Mainprize, Todd G., MD, Hynynen, Kullervo, PhD, Rutka, James T., MD, PhD

“…Abstract The blood brain barrier (BBB) is a major impediment to the delivery of therapeutics into the central nervous system (CNS). Gold nanoparticles (AuNPs)…”
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Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology by Etame, Arnold B, Diaz, Roberto J, Smith, Christian A, Mainprize, Todd G, Hynynen, Kullervo, Rutka, James T

“…Recent advances in molecular neurooncology provide unique opportunities for targeted molecular-based therapies. However, the blood-brain barrier (BBB) remains…”
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Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature by Etame, Arnold B., MD, Smith, Christian A., PhD, Chan, Warren C.W., PhD, Rutka, James T., MD, PhD

“…Abstract Gold nanoparticles (AuNPs) have gained prominence in several targeting applications involving systemic cancers. Their enhanced permeation and…”
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Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma by Faria, Claudia C, Golbourn, Brian J, Dubuc, Adrian M, Remke, Marc, Diaz, Roberto J, Agnihotri, Sameer, Luck, Amanda, Sabha, Nesrin, Olsen, Samantha, Wu, Xiaochong, Garzia, Livia, Ramaswamy, Vijay, Mack, Stephen C, Wang, Xin, Leadley, Michael, Reynaud, Denis, Ermini, Leonardo, Post, Martin, Northcott, Paul A, Pfister, Stefan M, Croul, Sidney E, Kool, Marcel, Korshunov, Andrey, Smith, Christian A, Taylor, Michael D, Rutka, James T

“…Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of…”
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aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb by Smith, Christian A, Lau, Kimberly M, Rahmani, Zohra, Dho, Sascha E, Brothers, Greg, She, Ye Min, Berry, Donna M, Bonneil, Eric, Thibault, Pierre, Schweisguth, François, Le Borgne, Roland, McGlade, C Jane

“…In Drosophila, the partition defective (Par) complex containing Par3, Par6 and atypical protein kinase C (aPKC) directs the polarized distribution and unequal…”
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A role for activated Cdc42 in glioblastoma multiforme invasion by Okura, Hidehiro, Golbourn, Brian J, Shahzad, Uswa, Agnihotri, Sameer, Sabha, Nesrin, Krieger, Jonathan R, Figueiredo, Carlyn A, Chalil, Alan, Landon-Brace, Natalie, Riemenschneider, Alexandra, Arai, Hajime, Smith, Christian A, Xu, Songli, Kaluz, Stefan, Marcus, Adam I, Van Meir, Erwin G, Rutka, James T

“…Cdc42 is a Rho-GTPase which plays a major role in regulating cell polarity and migration by specifying the localization of filopodia. However, the role of…”
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An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma by Kongkham, Paul N, Northcott, Paul A, Ra, Young Shin, Nakahara, Yukiko, Mainprize, Todd G, Croul, Sidney E, Smith, Christian A, Taylor, Michael D, Rutka, James T

“…Medulloblastoma (MB) is a malignant cerebellar tumor that occurs primarily in children. The hepatocyte growth factor (HGF)/MET pathway has an established role…”
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Successful Wildlife Conservation Requires Good Governance by Pomeranz, Emily F., Hare, Darragh, Decker, Daniel J., Forstchen, Ann B., Jacobson, Cynthia A., Smith, Christian A., Schiavone, Michael V.

“…Public wildlife management in the United States is transforming as agencies seek relevancy to broader constituencies. State agencies in the United States,…”
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The Role of Fascin in the Migration and Invasiveness of Malignant Glioma Cells by Hwang, Jeong Hyun, Smith, Christian A., Salhia, Bodour, Rutka, James T.

“…Malignant glioma is the most common primary brain tumor, and its ability to invade the surrounding brain parenchyma is a leading cause of tumor recurrence and…”
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Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma by Faria, Claudia, Agnihotri, Sameer, Mack, Stephen C., Golbourn, Brian J., Diaz, Roberto J., Olsen, Samantha, Bryant, Melissa, Bebenek, Matthew, Wang, Xin, Bertrand, Kelsey C., Kushida, Michelle, Head, Renee, Clark, Ian, Dirks, Peter, Smith, Christian A., Taylor, Michael D., Rutka, James T.

“…© Impact Journals, LLC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,…”
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The role of drebrin in glioma migration and invasion by Terakawa, Yuzo, Agnihotri, Sameer, Golbourn, Brian, Nadi, Mustafa, Sabha, Nesrin, Smith, Christian A., Croul, Sidney E., Rutka, James T.

“…Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite current advances in therapy consisting of surgery followed by chemotherapy and…”
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A functional genomics approach to identify pathways of drug resistance in medulloblastoma by Bertrand, Kelsey C, Faria, Claudia C, Skowron, Patryk, Luck, Amanda, Garzia, Livia, Wu, Xiaochong, Agnihotri, Sameer, Smith, Christian A, Taylor, Michael D, Mack, Stephen C, Rutka, James T

“…Keywords: Cancer, Brain tumor, Medulloblastoma, Drug resistance, Functional genomics, Transposon mutagenesis, Sleeping beauty…”
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High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in Chordoma Pathogenesis by Diaz, Roberto Jose, Guduk, Mustafa, Romagnuolo, Rocco, Smith, Christian A, Northcott, Paul, Shih, David, Berisha, Fitim, Flanagan, Adrienne, Munoz, David G, Cusimano, Michael D, Pamir, M. Necmettin, Rutka, James T

“…Abstract Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence…”
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The Role of State Wildlife Professionals Under the Public Trust Doctrine by Smith, Christian A

“…The Public Trust Doctrine (PTD) is considered the cornerstone of the North American Model of Wildlife Conservation. Effective application of the PTD requires a…”
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Essential Role of Human Dimensions and Stakeholder Participation in States’ Fulfillment of Public Trust Responsibilities by Forstchen, Ann B, Smith, Christian A

“…The Public Trust Doctrine (PTD) vests states with a fiduciary responsibility to manage wildlife for the benefit of current and future generations. States have…”
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The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cells by Osawa, Hirokatsu, Smith, Christian A, Ra, Young Shin, Kongkham, Paul, Rutka, James T

“…Medulloblastoma is a highly malignant brain tumor that occurs predominantly in children. The molecular pathogenesis of medulloblastoma is under investigation…”
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The Guanine Nucleotide Exchange Factor SWAP-70 Modulates the Migration and Invasiveness of Human Malignant Glioma Cells by Seol, Ho Jun, Smith, Christian A., Salhia, Bodour, Rutka, James T.

“…The malignant glioma is the most common primary human brain tumor. Its tendency to invade away from the primary tumor mass is considered a leading cause of…”
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Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in Medulloblastoma by Kongkham, Paul N., Onvani, Sara, Smith, Christian A., Rutka, James T.

“…Medulloblastoma is the most common pediatric posterior fossa malignancy, with a 5-year overall survival of only 60% and many survivors experiencing…”
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