Search Results - "Smith, Chase C"

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors by Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Gunzner-Toste, Janet, Liederer, Bianca M, Ly, Justin, O’Brien, Thomas, Oh, Angela, Wang, Leslie, Wang, Weiru, Xiao, Yang, Zak, Mark, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

“…Crystal structures of several urea- and thiourea-derived compounds in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein were utilized to…”
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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors by Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Gunzner-Toste, Janet, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

“…Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual screening identified a thiourea analogue, compound 5, as a novel…”
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Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors by Zheng, Xiaozhang, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Wang, Yunli, Yuen, Po-Wai, Bair, Kenneth W

“…A co-crystal structure of amide-containing compound (4) in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein and molecular modeling were…”
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First total synthesis of taxol. 2. Completion of the C and D rings by Holton, Robert A, Kim, Hyeong Baik, Somoza, Carmen, Liang, Feng, Biediger, Ronald J, Boatman, P. Douglas, Shindo, Mitsuru, Smith, Chase C, Kim, Soekchan

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Shot reproducibility of the self-magnetic-pinch diode at 4.5 MV by Bennett, Nichelle, Crain, M. Dale, Droemer, Darryl W., Gignac, Raymond E., Lare, Greg, Molina, Isidro, Obregon, Robert, Smith, Chase C., Wilkins, Frank L., Welch, Dale R., Cordova, Steve, Gallegos, Manuel L., Johnston, Mark D., Kiefer, Mark L., Leckbee, Joshua J., Mazarakis, Michael G., Nielsen, Dan, Renk, Timothy J., Romero, Tobias, Webb, Timothy J., Ziska, Derek

“…In experiments conducted at Sandia National Laboratories’ RITS-6 accelerator, the self-magnetic-pinch diode exhibits significant shot-to-shot variability…”
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First total synthesis of taxol. 1. Functionalization of the B ring by Holton, Robert A, Somoza, Carmen, Kim, Hyeong Baik, Liang, Feng, Biediger, Ronald J, Boatman, P. Douglas, Shindo, Mitsuru, Smith, Chase C, Kim, Soekchan

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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) by Zheng, Xiaozhang, Bair, Kenneth W., Bauer, Paul, Baumeister, Timm, Bowman, Krista K., Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Feng, Yezhen, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Li, Hong, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Ly, Justin, O’Brien, Thomas, Oeh, Jason, Oh, Angela, Reynolds, Dominic J., Sampath, Deepak, Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Tremayne, Jarrod, Wang, Leslie, Wang, Weiru, Wang, Zhongguo, Wu, Hongxing, Wu, Jiansheng, Xiao, Yang, Yang, Guangxing, Yuen, Po-wai, Zak, Mark, Dragovich, Peter S.

“…Potent, 1H-pyrazolo[3,4-b]pyridine-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using…”
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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility by Zak, Mark, Liederer, Bianca M., Sampath, Deepak, Yuen, Po-wai, Bair, Kenneth W., Baumeister, Timm, Buckmelter, Alexandre J., Clodfelter, Karl H., Cheng, Eric, Crocker, Lisa, Fu, Bang, Han, Bingsong, Li, Guangkun, Ho, Yen-Ching, Lin, Jian, Liu, Xiongcai, Ly, Justin, O’Brien, Thomas, Reynolds, Dominic J., Skelton, Nicholas, Smith, Chase C., Tay, Suzanne, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Dragovich, Peter S.

“…[Display omitted] Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility…”
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties by Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Mukadam, Sophie, O’Brien, Thomas, Oh, Angela, Reynolds, Dominic J., Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Sodhi, Jasleen, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang, Bair, Kenneth W., Dragovich, Peter S.

“…Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT)…”
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Back-streaming ion beam measurements in a self magnetic pinch (SMP) electron diode by Mazarakis, Michael G., Cordova, Steven R., Johnston, Mark D., Kiefer, Mark L., Leckbee, Joshua J., Nielsen, Dan S., Oliver, Bryan V., Renk, Timothy J., Webb, Timothy J., Ziska, Derek, Bennett, Nichelle, Droemer, Darryl W., Cignac, Raymond E., Obregon, Robert J., Smith, Chase C., Wilkins, Frank L., Welch, Dale R., Romero, Tobias M.

“…Summary form only given. A self-magnetic pinch diode (SMP) is presently the electron diode of choice for high energy flash x-ray radiography utilizing pulsed…”
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Contribution of the backstreaming ions to the Self-Magnetic pinch (SMP) diode current by Mazarakis, Michael G., Cuneo, Michael E., Fournier, Sean D., Johnston, Mark D., Kiefer, Mark L., Leckbee, Joshua J., Nielsen, Dan S., Oliver, Bryan V., Simpson, Sean, Renk, Timothy J., Webb, Timothy J., Ziska, Derek, Bennett, Nichelle, Droemer, Darryl W., Cignac, Raymond E., Obregon, Robert J., Smith, Chase C., Wilkins, Frank L., Welch, Dale R.

“…Summary form only given. The results presented here were obtained with an SMP diode mounted at the front high voltage end of the RITS accelerator. RITS is a…”
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Direct measurement of the bi-polar ion current and anode-cathode (A-K) voltage in a self-magnetic pinch (SMP) diode by Mazarakis, Michael G., Cordova, Steven R., Cuneo, Michael E., Johnston, Mark D., Kiefer, Mark L., Lake, Patrick W., Leckbee, Joshua J., Nielsen, Dan S., Oliver, Bryan V., Renk, Timothy J., Sceiford, Matthew, Simpson, Sean C., Webb, Timothy J., Ziska, Derek, Bennett, Nichelle, Crain, Marlon D., Droemer, Darryl W., Cignac, Raymond E., Lare, Gregory A., Molina, Isidro, Obregon, Robert J., Romero, Tobias M., Smith, Chase C., Wilkins, Frank L., Welch, Dale R.

“…Summary form only given. A self-magnetic pinch diode is currently under extensive study in the Sandia Laboratory advanced radiographic development facility…”
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Plasma dynamics in the self-magnetic-pinch diode by Bennett, Nichelle, Crane, Marlon D., Smith, Chase C., Droemer, Darryl W., Welch, Dale R., Johnston, Mark D., Leckbee, Joshua J., Mazarakis, Michael G., Renk, Timothy J., Webb, Timothy J., Keifer, Mark L.

“…The self-magnetic-pinch (SMP) diode 1,2 is being developed as a source for flash x-ray radiography. The high electric field stresses applied to this diode and…”
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Nitration of cyclopentenecarboxaldehyde: Studies toward 1-amino-2-nitrocyclopentanecarboxylic acid by Smith, Chase C., Jacyno, John M., Zeiter, Kendra K., Parkanzky, Paul D., Paxson, Chad E., Pekelnicky, Peter, Harwood, John S., Hunter, Allen D., Lucarelli, Vincent G., Lufaso, Michael W., Cutler, Horace G.

“…The formation of 2,2-dinitrocyclopentanone oxime is described during an attempted nitroacetamidation of cyclopentenecarboxaldehyde using ceric ammonium nitrate…”
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Synthetic studies toward the total synthesis of taxol. (Volumes I and II) by Smith, Chase C

“…The use of a total synthesis of taxol for producing a supply of taxol, while not a viable option at the present, may someday aid in the development of second…”
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Lithium Perchlorate Mediated Allylic Substitution Reaction Using a Cyclohexenyl Based Model System by Smith, Chase C., Rothhaar, Roger R., Thobe, Karla J., Crago, Cynthia M., Pekelnicky, Peter

“…A methodology was developed for the direct substitution of allylic alcohols and acetates by alcohol nucleophiles in order to synthesize allylic ethers. The…”
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