Search Results - "Smith, Carson L."

Adjuvant AS01 activates human monocytes for costimulation and systemic inflammation by Smith, Carson L., Richardson, Brian, Rubsamen, Michael, Cameron, Mark J., Cameron, Cheryl M., Canaday, David H.

“…•AS01 is a highly reactogenic adjuvant approved clinically for use in older adults.•AS01 induced a costimulatory phenotype in monocytes in vitro, but not…”
Get full text

Longitudinal Analysis of Nursing Home Residents’ T-Cell Responses After SARS-CoV-2 mRNA Vaccinations Shows Influence of Biological Sex and Infection History by Smith, Carson L, Didion, Elise, Aung, Htin, Tamilselvan, Banumathi, Bej, Taissa, Oyebanji, Oladayo A, Shive, Carey L, Wilson, Brigid M, Cameron, Mark, Cameron, Cheryl, Gravenstein, Stefan, Canaday, David H

“…Abstract Background Vaccines and vaccine boosting have blunted excess morbidity and mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
Get full text

Humoral and Cellular Immunity Induced by Adjuvanted and Standard Trivalent Influenza Vaccine in Older Nursing Home Residents by Smith, Carson L, Bednarchik, Beth, Aung, Htin, Wilk, Dennis J, Boxer, Rebecca S, Daddato, Andrea E, Wilson, Brigid M, Gravenstein, Stefan, Canaday, David H

“…Abstract Background Despite wide use of adjuvanted influenza vaccine in nursing home residents (NHR), little immunogenicity data exist for this population…”
Get full text

Adjuvant AS01 induces monocyte activation that favors T cell expansion and diversification in primary human cells by Smith, Carson L., Canaday, David H

“…Abstract Vaccines are less effective in older adults, and efforts to improve vaccine efficacy generally show limited clinical improvement. However, the vaccine…”
Get full text

Adjuvants and Age: Understanding Vaccine Response in Older Adults by Smith, Carson L

“…Vaccination forms an immune memory to protect organisms from pathogens. Vaccination remains a critical part of the public health arsenal against infectious…”
Get full text